The effects of linagliptin on endothelial function and global arginine bioavailability ratio in coronary artery disease patients with early diabetes: study protocol for a randomized controlled trial.

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:The burden of acute gastroenteritis on children and their families continues to be enormous. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although clinical trials in children with gastroenteritis have been p...

journal_title：Trials

authors： Freedman SB,Williamson-Urquhart S,Schuh S,Sherman PM,Farion KJ,Gouin S,Willan AR,Goeree R,Johnson DW,Black K,Schnadower D,Gorelick MH,Pediatric Emergency Research Canada (PERC) Gastroenteritis Study Group.

更新日期：2014-05-14 00:00:00

abstract：BACKGROUND:Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems to be an appealing option for prevention. The utility of such a strategy has never been challenged in...

journal_title：Trials

authors： Turrini F,Messora R,Giovanardi P,Tondi S,Magnavacchi P,Cavani R,Tosoni G,Cappelli C,Pellegrini E,Romano S,Baldini A,Zennaro RG,Bondi M

更新日期：2009-12-23 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis disease (CAD) is generally associated with the occurrence of cardiovascular and cerebrovascular accidents. However, CAD has not been taken seriously enough in the clinic, which, coupled with the single treatment and prevention of CAD, has led to a generally low level of patient compli...

journal_title：Trials

authors： Zhou J,Zhao L,Meng L,Liang H,Zhou T,Ye S,Qi Z,Huang X,Zhou P,Fu W

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual...

journal_title：Trials

authors： Hvenegaard M,Watkins ER,Poulsen S,Rosenberg NK,Gondan M,Grafton B,Austin SF,Howard H,Moeller SB

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...

journal_title：Trials

authors： Schlüssel MM,Keene DJ,Wagland S,Alsousou J,Lamb SE,Willett K,Dutton SJ,PATH-2 Trial Study Group.

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant) is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD). The primar...

journal_title：Trials

authors： Tsang TW,Kohn MR,Hermens DF,Clarke SD,Clark CR,Efron D,Cranswick N,Lamb C,Williams LM

更新日期：2011-03-13 00:00:00

abstract：BACKGROUND:Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe cases. While a recent systematic review suggested that "earlier" initiation of renal replacement therapy improves survival, completed trials are limited ...

journal_title：Trials

authors： Smith OM,Wald R,Adhikari NK,Pope K,Weir MA,Bagshaw SM,Canadian Critical Care Trials Group.

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:Surgery induces insulin resistance that might be alleviated by a nutritional drink given preoperatively. The authors hypothesized that some of the beneficial effects of the drink could be attributed to the volume component (approximately 1 L) rather than to the nutrients. METHODS:Sixty patients scheduled fo...

journal_title：Trials

authors： Ljunggren S,Hahn RG

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). O...

journal_title：Trials

authors： Poiani GDCR,Zaninotto AL,Carneiro AMC,Zangaro RA,Salgado ASI,Parreira RB,de Andrade AF,Teixeira MJ,Paiva WS

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a rapid-onset sensorineural hearing impairment with unclear etiology and unsatisfying treatment effects. Vestibular dysfunction has been considered as a poor indicator in the clinical manifestations and prognosis of ISSNHL, which occurred in approximat...

journal_title：Trials

authors： Hao W,Zhao L,Yu H,Li H

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patien...

journal_title：Trials

authors： Gray RJ,Myint PK,Elender F,Barton G,Pfeil M,Price G,Wyatt N,Ravenhill G,Thomas E,Jagger J,Hursey A,Waterfield K,Hardy S

更新日期：2011-04-30 00:00:00

abstract：BACKGROUND:The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and accepta...

journal_title：Trials

authors： White J,Gray RJ,Swift L,Barton GR,Jones M

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Generalized anxiety disorder (GAD) is a psychiatric disorder characterized by a constant and unspecific anxiety that interferes with daily-life activities. Its high prevalence in general population and the severe limitations it causes, point out the necessity to find new efficient strategies to treat it. Tog...

journal_title：Trials

authors： Gorini A,Riva G

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Anxiety in children is common and incapacitating and increases the risk of mental health disorders in adulthood. Although effective interventions are available, few children are identified and referred for specialist treatment. Alternative approaches in which prevention programmes are delivered in school app...

journal_title：Trials

authors： Stallard P,Taylor G,Anderson R,Daniels H,Simpson N,Phillips R,Skryabina E

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...

journal_title：Trials

authors： Schuit AS,Holtmaat K,Hooghiemstra N,Jansen F,Lissenberg-Witte BI,Coupé VMH,Verdonck-de Leeuw IM

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Attrition is problematic in trials, and may be exacerbated in longer studies, telehealth trials and participants with depression - three features of The Healthlines Study. Advance notification, including a photograph and using action-oriented email subject lines might increase response rates, but require fur...

journal_title：Trials

authors： Edwards L,Salisbury C,Horspool K,Foster A,Garner K,Montgomery AA

更新日期：2016-02-24 00:00:00

abstract：:Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...

journal_title：Trials

authors： Kappelmann N,Müller-Myhsok B,Kopf-Beck J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Burns and the associated wound care procedures can be extremely painful and anxiety-provoking for children. Burn injured children and adolescents are therefore at greater risk of experiencing a range of psychological reactions, in particular posttraumatic stress disorder, which can persist for months to year...

journal_title：Trials

authors： Chester SJ,Stockton K,De Young A,Kipping B,Tyack Z,Griffin B,Chester RL,Kimble RM

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Acute respiratory failure (ARF) remains the leading reason for intensive care unit (ICU) admission of immunocompromised patients. In the most severe cases, high-flow oxygen therapy may fail to ensure adequate gas exchange, and mechanical ventilation (MV) must be used. This scenario is associated with high mo...

journal_title：Trials

authors： Lemiale V,Resche-Rigon M,Azoulay E,Study Group for Respiratory Intensive Care in Malignancies Groupe de Recherche en Réanimation Respiratoire du patient d’Onco-Hématologie.

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:Depressive and anxiety disorders are common in general practice but not always treated adequately. Introducing stepped care might improve this. In this randomized trial we examined the effectiveness of such a stepped care model. METHODS:The study population consisted of primary care attendees aged 18-65 yea...

journal_title：Trials

authors： Seekles W,van Straten A,Beekman A,van Marwijk H,Cuijpers P

更新日期：2011-07-07 00:00:00

abstract：BACKGROUND:Among clinical trials of interventions that aim to modify time spent on mechanical ventilation for critically ill patients there is considerable inconsistency in chosen outcomes and how they are measured. The Core Outcomes in Ventilation Trials (COVenT) study aims to develop a set of core outcomes for use in...

journal_title：Trials

authors： Blackwood B,Ringrow S,Clarke M,Marshall J,Rose L,Williamson P,McAuley D

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have emerged as an alternative for cardiac diseases of distinct causes in experimental animal studies and m...

journal_title：Trials

authors： Tura BR,Martino HF,Gowdak LH,dos Santos RR,Dohmann HF,Krieger JE,Feitosa G,Vilas-Boas F,Oliveira SA,Silva SA,Bozza AZ,Borojevic R,de Carvalho AC

更新日期：2007-01-18 00:00:00

abstract：BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...

journal_title：Trials

authors： Jung DE,Lee HC,Yoon HK,Park HP

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...

journal_title：Trials

authors： Al-Shahi Salman R,Dennis MS,Murray GD,Innes K,Drever J,Dinsmore L,Williams C,White PM,Whiteley WN,Sandercock PAG,Sudlow CLM,Newby DE,Sprigg N,Werring DJ,RESTART collaborators.

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first cluster randomized controlled trial (RCT) to design and evaluate an intervention intended to improve inte...

journal_title：Trials

authors： Zwarenstein M,Reeves S,Russell A,Kenaszchuk C,Conn LG,Miller KL,Lingard L,Thorpe KE

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Depression accounts for the greatest burden of disease among all mental health problems, and is expected to become the second-highest amongst all general health problems by 2020. By the age of 75, 1 in 7 older people meet formal diagnostic criteria for depression. Efforts to ameliorate the burden of illness ...

journal_title：Trials

authors： Mitchell N,Hewitt C,Adamson J,Parrott S,Torgerson D,Ekers D,Holmes J,Lester H,McMillan D,Richards D,Spilsbury K,Godfrey C,Gilbody S

更新日期：2011-10-11 00:00:00