Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial.

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Combination immunochemotherapy such as fludarabine, cyclophosphamide and rituximab is the standard first line therapy in fit patients, but there is limited evidence regarding the optimal treatment of patients after relapse. Ofatumumab as...

journal_title：Trials

authors： Howard DR,Munir T,Hockaday A,Rawstron AC,Collett L,Oughton JB,Allsup D,Bloor A,Phillips D,Hillmen P

更新日期：2016-09-20 00:00:00

abstract：:Evidence-based treatment for pregnant women will ultimately require research conducted in the population of pregnant women. Currently, few scholars have addressed the issue of responsible inclusion of pregnant women in drug research. Because of additional risks associated with including pregnant women in drug research...

journal_title：Trials

authors： Roes KCB,van der Zande ISE,van Smeden M,van der Graaf R

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a university hospital for patients with frequent episodic or chronic tension-type headach...

journal_title：Trials

authors： Schiller J,Kellner T,Briest J,Hoepner K,Woyciechowski A,Ostermann A,Korallus C,Sturm C,Weiberlenn T,Jiang L,Egen C,Beissner F,Stiesch M,Karst M,Gutenbrunner C,Fink MG

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...

journal_title：Trials

authors： Cheung KW,Seto MTY,Ng EHY

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...

journal_title：Trials

authors： Liang J,Zhou X,Chen N,Li X,Yu H,Yang Y,Song Y,Du Q

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Eyes sustaining open globe trauma are at high risk of severe visual impairment. Ocular injuries which result in visual loss invariably affect the posterior segment of the eye, and prevention of visual loss involves posterior segment (vitreoretinal) surgery. Despite improvements in vitreoretinal surgical tech...

journal_title：Trials

authors： Banerjee PJ,Cornelius VR,Phillips R,Lo JW,Bunce C,Kelly J,Murphy C,Edwards RT,Robertson EL,Charteris DG

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:It is widely agreed that triglyceride (TG)-lowering therapy is imperative in early hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Intravenous insulin with or without heparin, and plasmapheresis are available regimens. However, there is no consensus on first-line therapy. METHODS/DESIGN:The Bi-TPA...

journal_title：Trials

authors： Song X,Shi D,Cui Q,Yu S,Yang J,Song P,Walline J,Xu J,Zhu H,Yu X

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:It is expected that in 2020 more than 17,000 cases of colorectal cancer will be diagnosed in The Netherlands. To date, patients are included in a surgeon-led follow-up programme whose main focus is recurrence detection. However, patients often experience multiple physical and psychosocial problems. Currently...

journal_title：Trials

authors： Duineveld LA,Wieldraaijer T,van Asselt KM,Nugteren IC,Donkervoort SC,van de Ven AW,Smits AB,van Geloven AA,Bemelman WA,Beverdam FH,van Tets WF,Govaert MJ,Bosmans JE,Verdonck-de Leeuw IM,van Uden-Kraan CF,van Weert HC,Wind

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their general practitioner (GP) in the first instance, with conse...

journal_title：Trials

authors： Frost J,Lane JA,Cotterill N,Fader M,Hackshaw-McGeagh L,Hashim H,Macaulay M,MacNeill SJ,Noble S,Rees J,Ridd MJ,Robles L,Taylor G,Taylor J,Drake MJ,Worthington J

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve o...

journal_title：Trials

authors： Underwood M,Eldridge S,Lamb S,Potter R,Sheehan B,Slowther AM,Taylor S,Thorogood M,Weich S

更新日期：2011-02-02 00:00:00

abstract：BACKGROUND:Symptoms in hypertrophic cardiomyopathy (HC) appear to be caused by diastolic dysfunction, myocardial ischemia, left ventricle (LV) outflow obstruction, and atrial fibrillation. However, clinical deterioration and severe heart failure symptoms can be observed in patients without any of these factors. Thus, t...

journal_title：Trials

authors： Bayrak F,Kahveci G,Degertekin M,Mutlu B

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe p...

journal_title：Trials

authors： Gomes BC,Rocca CC,Belizario GO,Lafer B

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Nursing home residents are frequently affected by joint contractures, which impacts their participation and daily activities. A complex intervention, the Participation Enabling Care in Nursing (PECAN), was previously developed and pilot tested to address their needs. Its effectiveness and safety will be eval...

journal_title：Trials

authors： Nguyen N,Thalhammer R,Beutner K,Saal S,Servaty R,Klingshirn H,Icks A,Freyberg K,Vomhof M,Mansmann U,Le L,Müller M,Meyer G

更新日期：2019-05-29 00:00:00

abstract：:There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...

journal_title：Trials

authors： Wilkinson T,Sinha S,Peek N,Geifman N

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappr...

journal_title：Trials

authors： Clare L,Woods RT,Whitaker R,Wilson BA,Downs M

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access. METHODS:A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for jus...

journal_title：Trials

authors： Kanarek NF,Kanarek MS,Olatoye D,Carducci MA

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:The insertion of central venous access devices, such as totally implantable venous access ports (TIVAPs), is routine in patients who need a safe and permanent venous access. The number of port implantations is increasing due to the development of innovative adjuvant and neo-adjuvant therapies. Currently, two...

journal_title：Trials

authors： Hüttner FJ,Bruckner T,Alldinger I,Hennes R,Ulrich A,Büchler MW,Diener MK,Knebel P

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical ventilation (MV). Neurally Adjusted Ventilatory Assist (NAVA) is a novel approach to MV based on ne...

journal_title：Trials

authors： Villar J,Belda J,Blanco J,Suarez-Sipmann F,Añón JM,Pérez-Méndez L,Ferrando C,Parrilla D,Montiel R,Corpas R,González-Higueras E,Pestaña D,Martínez D,Fernández L,Soro M,García-Bello MA,Fernández RL,Kacmarek RM,NAVa In A

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite e...

journal_title：Trials

authors： Robertson K,Marshman LAG,Hennessy M,Harriss L,Plummer D

更新日期：2018-01-09 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of...

journal_title：Trials

authors： Casper M,Mengel M,Fuhrmann C,Herrmann E,Appenrodt B,Schiedermaier P,Reichert M,Bruns T,Engelmann C,Grünhage F,Lammert F,INCA trial group.

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:Children can find anaesthesia induction especially distressing and postoperative psychological and physical morbidity are common. Preparation programmes for general anaesthesia (GA) are highly effective in reducing this distress. A Phase II study has already verified the effectiveness of a prototype preopera...

journal_title：Trials

authors： Hosey MT,Donaldson AN,Huntington C,Liossi C,Reynolds PA,Alharatani R,Newton JT

更新日期：2014-06-11 00:00:00

abstract：BACKGROUND:Burnout is an occupational syndrome that leads to mental health problems, job turnover, and patient safety events. Those caring for critically ill patients are especially susceptible due to high patient mortality, long hours, and regular encounters with trauma and ethical issues. Interventions to prevent bur...

journal_title：Trials

authors： Bateman ME,Hammer R,Byrne A,Ravindran N,Chiurco J,Lasky S,Denson R,Brown M,Myers L,Zu Y,Denson JL

更新日期：2020-12-11 00:00:00

abstract：BACKGROUND:Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia and fatigue. Exposure to high altitude can also lead to high-altitude cerebral oedema (HACE), which is a potential cause of death whilst mountainee...

journal_title：Trials

authors： Fisher O,Benson RA,Wayte S,Kimani PK,Hutchinson C,Imray CHE

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill this knowledge gap, this protocol proposes an appropriately powered, prospective, evaluator-blinded, ...

journal_title：Trials

authors： Forestier R,Suehs C,Françon A,Marty M,Genevay S,Sellam J,Chauveton C,Erol Forestier FB,Molinari N

更新日期：2020-05-11 00:00:00