当前位置： SCI文献检索 > Trials期刊下所有文献 > Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial.

Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial.

Abstract：

BACKGROUND:Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical ventilation (MV). Neurally Adjusted Ventilatory Assist (NAVA) is a novel approach to MV based on neural respiratory center output that is able to trigger, cycle, and regulate the ventilatory cycle. We hypothesized that the use of NAVA compared to conventional lung-protective MV will result in a reduction of the duration of MV. It is further hypothesized that NAVA compared to conventional lung-protective MV will result in a decrease in the length of ICU and hospital stay, and mortality. METHODS/DESIGN:This is a prospective, multicenter, randomized controlled trial in 306 mechanically ventilated patients with acute respiratory failure from several etiologies. Only patients ventilated for less than 5 days, and who are expected to require prolonged MV for an additional 72 h or more and are able to breathe spontaneously, will be considered for enrollment. Eligible patients will be randomly allocated to two ventilatory arms: (1) conventional lung-protective MV (n = 153) and conventional lung-protective MV with NAVA (n = 153). Primary outcome is the number of ventilator-free days, defined as days alive and free from MV at day 28 after endotracheal intubation. Secondary outcomes are total length of MV, and ICU and hospital mortality. DISCUSSION:This is the first randomized clinical trial examining, on a multicenter scale, the beneficial effects of NAVA in reducing the dependency on MV of patients with acute respiratory failure. TRIAL REGISTRATION:ClinicalTrials.gov website ( NCT01730794 ). Registered on 15 November 2012.

journal_name

Trials

journal_title

Trials

authors

Villar J,Belda J,Blanco J,Suarez-Sipmann F,Añón JM,Pérez-Méndez L,Ferrando C,Parrilla D,Montiel R,Corpas R,González-Higueras E,Pestaña D,Martínez D,Fernández L,Soro M,García-Bello MA,Fernández RL,Kacmarek RM,NAVa In A

doi

10.1186/s13063-016-1625-5

subject

Has Abstract

pub_date

2016-10-13 00:00:00

pages

500

issue

1

issn

1745-6215

pii

10.1186/s13063-016-1625-5

journal_volume

17

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

Trials文献大全