Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts.

abstract：BACKGROUND:Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-...

journal_title：Trials

authors： Ahn S,LOCAT group.

更新日期：2014-01-17 00:00:00

abstract：:Mental health problems are highly prevalent in children and adolescents, but professional help-seeking behavior in this age group is extremely low. Therefore, the ProHEAD ("Promoting Help-seeking using E-technology for Adolescents") consortium focuses on three main objectives, i.e.: (1) improving young people's help-s...

journal_title：Trials

authors： Kaess M,Bauer S

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (I...

journal_title：Trials

authors： Merrill PD,McClure LA

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Colonoscopy is one of the most effective methods of cancer prevention and detection, particularly for individuals with familial risk. Recruitment of family members to behavioral intervention trials remains uniquely challenging, owing to the intensive process required to identify and contact them. Recruiting ...

journal_title：Trials

authors： Simmons RG,Lee YC,Stroup AM,Edwards SL,Rogers A,Johnson C,Wiggins CL,Hill DA,Cress RD,Lowery J,Walters ST,Jasperson K,Higginbotham JC,Williams MS,Burt RW,Schwartz MD,Kinney AY

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...

journal_title：Trials

authors： Borgen IMH,Løvstad M,Andelic N,Hauger S,Sigurdardottir S,Søberg HL,Sveen U,Forslund MV,Kleffelgård I,Lindstad MØ,Winter L,Røe C

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...

journal_title：Trials

authors： Peng Y,You H,Chen X,Chen Y,Yang Y,Huang J,Xu N,Liu J

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Depression is not a normal side effect of aging, however it is one of the most prevalent mental health issues in later life, imposing a tremendous burden on patients, their families, and the healthcare system. We describe the experimental implementation of a collaborative, stepped-care model for the treatmen...

journal_title：Trials

authors： Wernher I,Bjerregaard F,Tinsel I,Bleich C,Boczor S,Kloppe T,Scherer M,Härter M,Niebling W,König HH,Hüll M

更新日期：2014-09-06 00:00:00

abstract：BACKGROUND:Three decades of research suggests that prevention of iron deficiency anemia (IDA) in the primary care setting may be an unrealized and unique opportunity to prevent poor developmental outcomes in children. A longitudinal study of infants with IDA showed that the developmental disadvantage persists long term...

journal_title：Trials

authors： Abdullah K,Thorpe KE,Mamak E,Maguire JL,Birken CS,Fehlings D,Hanley AJ,Macarthur C,Zlotkin SH,Parkin PC

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access. METHODS:A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for jus...

journal_title：Trials

authors： Kanarek NF,Kanarek MS,Olatoye D,Carducci MA

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:A large number of stakeholders have accepted the need for greater transparency in clinical research and, in the context of various initiatives and systems, have developed a diverse and expanding number of repositories for storing the data and documents created by clinical studies (collectively known as data ...

journal_title：Trials

authors： Canham S,Ohmann C

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables addition...

journal_title：Trials

authors： Gray AJ,Roobottom C,Smith JE,Goodacre S,Oatey K,O'Brien R,Storey RF,Na L,Lewis SC,Thokala P,Newby DE

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy o...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Hand-assisted laparoscopic living donor nephrectomy (HALDN) using a periumbilical or Pfannenstiel incision was developed to improve donor outcome after a kidney transplant. The aim of this study was to investigate two methods of hand assistance and kidney removal during HALDN and their effect on the time it ...

journal_title：Trials

authors： Kulu Y,Müller-Stich BP,Ghamarnejad O,Khajeh E,Polychronidis G,Golriz M,Nickel F,Benner L,Knebel P,Diener M,Morath C,Zeier M,Büchler MW,Mehrabi A

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:The increasing prevalence of Alzheimer's disease and other forms of dementia raises new challenges to ensure that healthcare decisions are informed by research evidence and reflect what is important for seniors and their caregivers. Therefore, we aim to evaluate a tailored intervention to help healthcare pro...

journal_title：Trials

authors： Giguere AMC,Lawani MA,Fortier-Brochu É,Carmichael PH,Légaré F,Kröger E,Witteman HO,Voyer P,Caron D,Rodríguez C

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual r...

journal_title：Trials

authors： Wang YL,Gao HX,Wang JS,Wang JH,Bo L,Zhang TT,Dai YL,Gao LL,Liu Q,Zhang JJ,Cai JM,Yu JQ,Li YX

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...

journal_title：Trials

authors： Gu J,Miller CB,Henry AL,Espie CA,Davis ML,Stott R,Emsley R,Smits JAJ,Craske M,Saunders KEA,Goodwin G,Carl JR

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. We report a protocol of a multicenter, randomized, double-blind, sham-controlled paralle...

journal_title：Trials

authors： Lim R,Liong ML,Leong WS,Khan NA,Yuen KH

更新日期：2015-06-21 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) exhibit increased morbidity and mortality which is associated with an increased systemic inflammatory burden. Identifying and managing comorbid diseases that contribute to this load may inform novel care pathways that could have a beneficial impact on the morbidity/...

journal_title：Trials

authors： Sharma P,Cockwell P,Dietrich T,Ferro C,Ives N,Chapple ILC

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...

journal_title：Trials

authors： Sun H,Cao Y,Han S,Cheng R,Liu L,Liu J,Xia S,Zhang J,Li Z,Cheng X,Yang C,Pan X,Li L,Ding X,Wang R,Wu M,Li X,Shi L,Xu F,Yu F,Pan J,Zhang X,Li L,Yang J,Li M,Yan C,Zhou Q,Lu J,Wei M,Wang L,Yang L,

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Cardiovascular diseases (CVDs) remain the leading causes of morbidity and mortality in the world. Hypertension is an important and prevalent cardiovascular risk factor. The present study will be conducted to investigate the effect of barberry as a cardio-protective fruit on the blood pressure in patients wit...

journal_title：Trials

authors： Emamat H,Zahedmehr A,Asadian S,Tangestani H,Nasrollahzadeh J

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that may improve health by breaking the cycle of poverty. However, there is a lack of reliable evidence to ...

journal_title：Trials

authors： Ojha S,Szatkowski L,Sinha R,Yaron G,Fogarty A,Allen S,Choudhary S,Smyth AR

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:Same-sex attracted young adults have been found to experience higher rates of mental health problems and greater difficulties in accessing specialist mental health care services compared to their heterosexual peers. Internet-based mental health interventions have the potential to be more engaging and accessi...

journal_title：Trials

authors： Abbott JA,Klein B,McLaren S,Austin DW,Molloy M,Meyer D,McLeod B

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients' general activity and increases the length of hospital stays and the use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. ...

journal_title：Trials

authors： Depaulis C,Steer N,Garessus L,Chassard D,Aubrun F

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:Intraoperative driving pressure (ΔP) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (VT) is kept constant, ΔP may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. ΔP may decrease if PEEP leads to a recruitment of c...

journal_title：Trials

authors： DESIGNATION–investigators.

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Practicing activities improves recovery after stroke, but many people in hospital do little activity. Feedback on activity using an accelerometer is a potential method to increase activity in hospital inpatients. This study's goal is to investigate the effect of feedback, enabled by a Smart watch, on daily p...

journal_title：Trials

authors： Dong Y,Steins D,Sun S,Li F,Amor JD,James CJ,Xia Z,Dawes H,Izadi H,Cao Y,Wade DT,Smart watch activity feedback trial committee (SWAFT).

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Low mood is a common mental health problem with significant health consequences. Studies have shown that cognitive behavioural therapy (CBT) is an effective treatment for low mood and anxiety when delivered one-to-one by an expert practitioner. However, access to this talking therapy is often limited and wai...

journal_title：Trials

authors： Williams C,McClay CA,Martinez R,Morrison J,Haig C,Jones R,Farrand P

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common cause of pain and disability. Currently available analgesics are often insufficiently effective or have unacceptable adverse effects. Tricyclic antidepressants may offer a useful centrally-acting analgesic. Nortriptyline is a readily-available, cheap and comparatively well-tol...

journal_title：Trials

authors： Hudson B,Williman JA,Stamp LK,Alchin JS,Hooper GJ,Mangin D,Thompson BF,Toop L

更新日期：2015-10-09 00:00:00