Core outcomes in periodontal trials: study protocol for core outcome set development.

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointments for residual memory problems following discharge. METHODS/DESIGN:Thi...

journal_title：Trials

authors： das Nair R,Lincoln NB,Ftizsimmons D,Brain N,Montgomery A,Bradshaw L,Drummond A,Sackley C,Newby G,Thornton J,Stapleton S,Pink A

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant) is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD). The primar...

journal_title：Trials

authors： Tsang TW,Kohn MR,Hermens DF,Clarke SD,Clark CR,Efron D,Cranswick N,Lamb C,Williams LM

更新日期：2011-03-13 00:00:00

abstract：BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...

journal_title：Trials

authors： Bulteau S,Laurin A,Volteau C,Dert C,Lagalice L,Schirr-Bonnans S,Bukowski N,Guitteny M,Simons L,Cabelguen C,Pichot A,Tessier F,Bonnin A,Lepage A,ACOUSTIM Investigators Group.,HUGOPSY Network.,Vanelle JM,Sauvaget A,Rich

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The Europ...

journal_title：Trials

authors： Vlasov H,Juvonen T,Hiippala S,Suojaranta R,Peltonen M,Schramko A,Arvonen K,Salminen US,Kleine Budde I,Eränen T,Mazanikov M,Meinberg M,Vähäsilta T,Wilkman E,Pettilä V,Pesonen E

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...

journal_title：Trials

authors： Liang J,Zhou X,Chen N,Li X,Yu H,Yang Y,Song Y,Du Q

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Colonoscopy is one of the most effective methods of cancer prevention and detection, particularly for individuals with familial risk. Recruitment of family members to behavioral intervention trials remains uniquely challenging, owing to the intensive process required to identify and contact them. Recruiting ...

journal_title：Trials

authors： Simmons RG,Lee YC,Stroup AM,Edwards SL,Rogers A,Johnson C,Wiggins CL,Hill DA,Cress RD,Lowery J,Walters ST,Jasperson K,Higginbotham JC,Williams MS,Burt RW,Schwartz MD,Kinney AY

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...

journal_title：Trials

authors： Cheung KW,Seto MTY,Ng EHY

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that may improve health by breaking the cycle of poverty. However, there is a lack of reliable evidence to ...

journal_title：Trials

authors： Ojha S,Szatkowski L,Sinha R,Yaron G,Fogarty A,Allen S,Choudhary S,Smyth AR

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectiveness of an Internet-delivered behavioural intervention (called BIP TIC) comp...

journal_title：Trials

authors： Khan K,Hollis C,Hall CL,Davies EB,Mataix-Cols D,Andrén P,Murphy T,Brown BJ,Murray E,Glazebrook C

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis disease (CAD) is generally associated with the occurrence of cardiovascular and cerebrovascular accidents. However, CAD has not been taken seriously enough in the clinic, which, coupled with the single treatment and prevention of CAD, has led to a generally low level of patient compli...

journal_title：Trials

authors： Zhou J,Zhao L,Meng L,Liang H,Zhou T,Ye S,Qi Z,Huang X,Zhou P,Fu W

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Cardiovascular diseases (CVDs) remain the leading causes of morbidity and mortality in the world. Hypertension is an important and prevalent cardiovascular risk factor. The present study will be conducted to investigate the effect of barberry as a cardio-protective fruit on the blood pressure in patients wit...

journal_title：Trials

authors： Emamat H,Zahedmehr A,Asadian S,Tangestani H,Nasrollahzadeh J

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic...

journal_title：Trials

authors： Garcia ES,Veiga DF,Veiga-Filho J,Cabral IV,Pinto NL,Novo NF,Sabino Neto M,Ferreira LM

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Previous studies have shown that acupuncture and electroacupuncture (EA) are effective in the treatment of patients with low back pain. However, there is little evidence to support the use of one intervention over the other. The aim of this study is to compare the effect of acupuncture and electroacupuncture...

journal_title：Trials

authors： Comachio J,Oliveira Magalhães M,Nogueira Burke T,Vidal Ramos LA,Peixoto Leão Almeida G,Silva AP,Ferreira de Meneses SR,Costa-Frutuoso JR,Santos Miotto Amorim C,Pasqual Marques A

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Burns and the associated wound care procedures can be extremely painful and anxiety-provoking for children. Burn injured children and adolescents are therefore at greater risk of experiencing a range of psychological reactions, in particular posttraumatic stress disorder, which can persist for months to year...

journal_title：Trials

authors： Chester SJ,Stockton K,De Young A,Kipping B,Tyack Z,Griffin B,Chester RL,Kimble RM

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key aspects of self-management such as self-monitoring of behaviours and symptoms, coupled with regular fe...

journal_title：Trials

authors： Ahmed S,Bartlett SJ,Ernst P,Paré G,Kanter M,Perreault R,Grad R,Taylor L,Tamblyn R

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Combination immunochemotherapy such as fludarabine, cyclophosphamide and rituximab is the standard first line therapy in fit patients, but there is limited evidence regarding the optimal treatment of patients after relapse. Ofatumumab as...

journal_title：Trials

authors： Howard DR,Munir T,Hockaday A,Rawstron AC,Collett L,Oughton JB,Allsup D,Bloor A,Phillips D,Hillmen P

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure an...

journal_title：Trials

authors： de Bont PA,van den Berg DP,van der Vleugel BM,de Roos C,Mulder CL,Becker ES,de Jongh A,van der Gaag M,van Minnen A

更新日期：2013-05-23 00:00:00

abstract：:After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...

journal_title：Trials

authors： Tegtmeier F,Schinzel R,Beer R,Bulters D,LeFrant JY,Sahuquillo J,Unterberg A,Andrews P,Belli A,Ibanez J,Lagares A,Mokry M,Willschke H,Flüh C,Schmutzhard E,NOSTRA Investigators.

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...

journal_title：Trials

authors： Graham HR,Ayede AI,Bakare AA,Oyewole OB,Peel D,Gray A,McPake B,Neal E,Qazi S,Izadnegahdar R,Falade AG,Duke T

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:There is an urgent need for clinically effective and cost-effective methods to manage antisocial and criminal behaviour in adolescents. Youth conduct disorder is increasingly prevalent in the UK and is associated with a range of negative outcomes. Quantitative systematic reviews carried out for the National ...

journal_title：Trials

authors： Fonagy P,Butler S,Goodyer I,Cottrell D,Scott S,Pilling S,Eisler I,Fuggle P,Kraam A,Byford S,Wason J,Haley R

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Recently, clinical observations reported the potential benefit of vagus nerve stimulation (VNS) for pediatric epilepsy. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a newer non-invasive VNS, making it more accessible for treating pediatric epilepsy, yet there is limited clinical evidence for ...

journal_title：Trials

authors： He W,Wang XY,Zhou L,Li ZM,Jing XH,Lv ZL,Zhao YF,Shi H,Hu L,Su YS,Zhu B

更新日期：2015-08-21 00:00:00