Effect of physical exercise on spontaneous physical activity energy expenditure and energy intake in overweight adults (the EFECT study): a study protocol for a randomized controlled trial.

abstract：BACKGROUND:Severe thrombocytopenia should be corrected by prophylactic platelet transfusion prior to central venous catheter (CVC) insertion, according to national and international guidelines. Even though correction is thought to prevent bleeding complications, evidence supporting the routine administration of prophyl...

journal_title：Trials

authors： van de Weerdt EK,Biemond BJ,Zeerleder SS,van Lienden KP,Binnekade JM,Vlaar APJ,Study collaborative.

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Intraoperative driving pressure (ΔP) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (VT) is kept constant, ΔP may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. ΔP may decrease if PEEP leads to a recruitment of c...

journal_title：Trials

authors： DESIGNATION–investigators.

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretation of the hazard ratio...

journal_title：Trials

authors： Royston P,B Parmar MK

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes (T2DM) are at increased risk for macrovascular events as well as for microvascular complications. There is evidence that in patients with coronary artery disease (CAD), about 35 % suffer from manifest T2DM. Early glucose-lowering intervention in subjects with T2DM has been demon...

journal_title：Trials

authors： Tripolt NJ,Aberer F,Riedl R,Hutz B,Url J,Dimsity G,Meinitzer A,Stojakovic T,Hödl R,Brodmann M,Hafner F,Sourij H

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this inter...

journal_title：Trials

authors： Nóbrega SR,Chachá SGF,Libardi CA

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Individuals who sustain traumatic brain injuries (TBIs) often continue to experience significant impairment of cognitive functions mediated by the prefrontal cortex well into chronic stages of recovery. Traditional brain training programs that focus on improving specific skills fall short of addressing integ...

journal_title：Trials

authors： Krawczyk DC,Marquez de la Plata C,Schauer GF,Vas AK,Keebler M,Tuthill S,Gardner C,Jantz T,Yu W,Chapman SB

更新日期：2013-01-30 00:00:00

abstract：BACKGROUND:Subacromial impingement syndrome (SIS) is a painful, and often long lasting, shoulder condition affecting patient function and quality of life. In a recent study, we observed major strength impairments in shoulder external rotation and abduction (~30%) in a population of patients with pronounced and long-las...

journal_title：Trials

authors： Clausen MB,Bandholm T,Rathleff MS,Christensen KB,Zebis MK,Graven-Nielsen T,Hölmich P,Thorborg K

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As address...

journal_title：Trials

authors： Asadpour R,Kessel KA,Bruckner T,Sertel S,Combs SE

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical paramet...

journal_title：Trials

authors： Balsam P,Ozierański K,Tymińska A,Główczyńska R,Peller M,Fojt A,Cacko A,Sieradzki B,Bakuła E,Markulis M,Kowalik R,Huczek Z,Filipiak KJ,Opolski G,Grabowski M

更新日期：2017-01-23 00:00:00

abstract：:Periconceptional supplementation could extend the period over which maternal and fetal nutrition is improved, but there are many challenges facing early-life intervention studies. Periconceptional trials differ from pregnancy supplementation trials, not only because of the very early or pre-gestational timing of nutri...

journal_title：Trials

authors： Brabin BJ,Gies S,Owens S,Claeys Y,D'Alessandro U,Tinto H,Brabin L

更新日期：2016-01-30 00:00:00

abstract：BACKGROUND:Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese he...

journal_title：Trials

authors： Chan RY,Chien WT

更新日期：2014-07-02 00:00:00

abstract：BACKGROUND:Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient's quality of life. In this context this study aims at reducing ...

journal_title：Trials

authors： Meyerhof E,Sprave T,Welte SE,Nicolay NH,Förster R,Bostel T,Bruckner T,Schlampp I,Debus J,Rief H

更新日期：2017-03-03 00:00:00

abstract：BACKGROUND:The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and accepta...

journal_title：Trials

authors： White J,Gray RJ,Swift L,Barton GR,Jones M

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to partici...

journal_title：Trials

authors： Parker A,Knapp P,Treweek S,Madhurasinghe V,Littleford R,Gallant S,Sullivan F,Schembri S,Rick J,Graffy J,Collier DJ,Eldridge S,Kennedy A,Bower P

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic...

journal_title：Trials

authors： Garcia ES,Veiga DF,Veiga-Filho J,Cabral IV,Pinto NL,Novo NF,Sabino Neto M,Ferreira LM

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measuremen...

journal_title：Trials

authors： Richert L,Uebelhart B,Engelhardt M,Azria M,Rizzoli R

更新日期：2008-04-13 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. POAF is associated with increased morbidity and hospital costs. We herein describe the protocol for a randomized controlled trial to determine if performing a posterior left pericardiotomy prevents POAF after cardiac...

journal_title：Trials

authors： Abouarab AA,Leonard JR,Ohmes LB,Lau C,Rong LQ,Ivascu NS,Pryor KO,Munjal M,Crea F,Massetti M,Sanna T,Girardi LN,Gaudino M

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:More than 60,000 people have health problems due to chemical weapons exposure during the Iran-Iraq war. Respiratory consequences of mustard gas exposure are common and disabling; medical interventions have limited effect. Patients complain of cough, sputum, breathlessness and exercise limitation. We hypothes...

journal_title：Trials

authors： Sedighi Moghadam MR,Ghanei M,Kenn K,Hopkinson NS

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Published evaluations of successful interventions to prevent falls in people with sight impairment (SI) are limited. The aim of this feasibility study is to optimise the design and investigation of home safety (HS) and home exercise (HE) programmes to prevent falls in older people with SI. METHODS:A communi...

journal_title：Trials

authors： Waterman H,Ballinger C,Brundle C,Chastin S,Gage H,Harper R,Henson D,Laventure B,McEvoy L,Pilling M,Olleveant N,Skelton DA,Stanford P,Todd C

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Approximately 40% of the newly diagnosed patients with advanced ovarian cancer are aged 70 years or older. Standard treatment for advanced disease consists of cytoreductive surgery and combination chemotherapy. In older patients, standard treatment is often withheld or prematurely stopped due to suspected fr...

journal_title：Trials

authors： van Soolingen NJ,Smorenburg CH,Hamaker ME,Groen WG,Retèl VP,Lok CAR,van de Poll-Franse LV,Trum JW

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients' general activity and increases the length of hospital stays and the use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. ...

journal_title：Trials

authors： Depaulis C,Steer N,Garessus L,Chassard D,Aubrun F

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context...

journal_title：Trials

authors： Rosso-Fernández C,Garnacho-Montero J,Antonelli M,Dimopoulos G,Cisneros JM,MagicBullet study group.

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of th...

journal_title：Trials

authors： Seo BK,Lee JH,Sung WS,Song EM,Jo DJ

更新日期：2013-01-14 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...

journal_title：Trials

authors： Chen X,Jiang W,Lin X,Lundborg CS,Wen Z,Lu W,Marrone G

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Gestational diabetes (GDM) is associated with an increased lifetime risk for the development of glucose abnormalities, metabolic syndrome, cardiovascular disease, depression and tumours. Despite this high risk of additional comorbidities, there is no standardised approach to the long-term follow-up of women ...

journal_title：Trials

authors： Bogdanet D,Egan A,Fhelelboom N,Biesty L,Thangaratinam S,Dempsey E,Crowther C,Devane D,Dunne F

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Temporomandibular disorder (TMD) is a condition encompassing clinical symptoms of the temporomandibular joint, masseter muscle, and surrounding structures. Hominis placental pharmacopuncture (HPP), consisting of human placental extract, has been reported as effective for treating chronic musculoskeletal diso...

journal_title：Trials

authors： Kim J,Park KS,Lee YJ,Kim KW,Cho JH,Ha IH

更新日期：2020-06-15 00:00:00