Abstract:
OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of morphine group (L group), medium concentration of morphine group (M group), high concentration of morphine group (H group), medium concentration of morphine and naloxone mixed with antagonist group (NM group). Rabbits in these five groups were administered with an epidural puncture tube and dorsal epidural analgesia pump, and were continuously infused for seven days. Fecal characteristics were observed, and the ink propulsion rate was calculated. The expression level of ICC C-kit protein in colon tissues was tested by western blot. RESULTS:The stool characteristics in the L, M and H groups were more severe than those in the NS and NM groups. Furthermore, the intestinal propulsion rate in the L, M and H groups was lower than that in the NS and NM groups. The C-kit mRNA and protein expression in the colon of rabbits were significantly lower in the L, M and H groups, when compared to the NS and NM groups. CONCLUSION:Naloxone blocked the mRNA and protein expression of C-kit, and improved intestinal motor function.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Yang H,Jin XJ,Luo H,Li YHdoi
10.2174/1566524019666191023112837subject
Has Abstractpub_date
2020-01-01 00:00:00pages
240-246issue
3eissn
1566-5240issn
1875-5666pii
CMM-EPUB-101807journal_volume
20pub_type
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更新日期:2004-06-01 00:00:00
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