Abstract:
:The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retinal vein occlusions (RVO) and ocular tumors. Because neovascularization is the common pathway to blindness in these highly prevalent conditions, the recent understanding of the cascade of angiogenesis has led to clinically available molecular therapeutics that have been proven to restore and preserve vision in patients that suffer from these blinding conditions. This article will summarize the emergence of vascular endothelial growth factor (VEGF) as a validated treatment target for and current understanding of the pathophysiology of ocular neovascularization. The article will then cover promising future strategies and therapeutic targets that are aimed at enhancing the efficacy and/or duration of effect of these clinically available anti-VEGF strategies. In particular molecules that target, VEGF, PDGF, Complement, Inflammation and Integrins that are entering or are currently in clinical trials will be reviewed.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Tolentino MJdoi
10.2174/156652409789712783subject
Has Abstractpub_date
2009-11-01 00:00:00pages
973-81issue
8eissn
1566-5240issn
1875-5666journal_volume
9pub_type
杂志文章,评审abstract::Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...
journal_title:Current molecular medicine
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journal_title:Current molecular medicine
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abstract::The acquisition of cellular immortality is a critical step in human tumorigenesis. While the vast majority of human tumors activate the catalytic component of telomerase (hTERT) to stabilize their telomeres and attain immortality, a significant portion (7-10%) utilize a poorly defined alternative form of telomere main...
journal_title:Current molecular medicine
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doi:10.2174/1566524053586653
更新日期:2005-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2006-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2011-07-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2020-09-15 00:00:00
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journal_title:Current molecular medicine
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更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Seven isoforms of histone deacetylase Class III have been reported - Sirtuin (SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligationand- puncture (CLP)-induced septic shock. Our present study was aimed at determining whether selecti...
journal_title:Current molecular medicine
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2008-03-01 00:00:00
abstract::In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...
journal_title:Current molecular medicine
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2011-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
abstract::In sum, the FTIs are signal transduction inhibitors that display promising clinical activity against a broad spectrum of malignancies. We are just beginning to explore and elucidate the mechanisms by which transformed cells respond to FTIs and the optimal settings in which they do so. The clinical trials that are curr...
journal_title:Current molecular medicine
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更新日期:2005-11-01 00:00:00
abstract::Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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abstract::A framework was developed to provide an integrated view of mycobacterial growth and its regulation. The topics reviewed include the properties of cell cultures and their relation to properties of individual cells, cell sizes and macromolecular compositions, uptake of nutrients through the cell envelope, protein biosyn...
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更新日期:2007-05-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2009-06-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2011-04-01 00:00:00
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更新日期:2015-01-01 00:00:00
abstract::Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and g...
journal_title:Current molecular medicine
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更新日期:2018-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2020-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2015-01-01 00:00:00