Ipsilateral hippocampal proteomics reveals mitochondrial antioxidative stress impairment in cortical-lesioned chronic mild stressed rats.

abstract：:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...

journal_title：Current molecular medicine

authors： Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJ

更新日期：2007-02-01 00:00:00

abstract：:WHIM syndrome is a dominantly inherited primary immunodeficiency disorder representing the first identified example of human disease caused by mutations in the gene encoding for the chemokine receptor CXCR4. Pathogenesis is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL1...

journal_title：Current molecular medicine

authors： Dotta L,Tassone L,Badolato R

更新日期：2011-06-01 00:00:00

abstract：:The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. Increase in sedentary lifestyle and consumption of more energy-dense diet increased the incidence of obesity which is a significant ri...

journal_title：Current molecular medicine

authors： Yaribeygi H,Maleki M,Sathyapalan T,Jamialahmadi T,Sahebkar A

更新日期：2020-08-12 00:00:00

abstract：:Mistletoe is often used as complementary therapy in oncology. The anti-tumor effects of mistletoe (Iscador) are well documented in-vitro in respect to inhibition of cell proliferation, induction of apoptosis, segmental activation of immune competent cells and trapping of chemotherapeutic drugs within cancer cells by m...

journal_title：Current molecular medicine

authors： Matthes H,Friedel WE,Bock PR,Zänker KS

更新日期：2010-06-01 00:00:00

abstract：:HIV infection causes an acquired immunodeficiency, principally because of depletion of CD4 lymphocytes. The mechanism by which the virus depletes these cells, however, is not clearly understood. Since the virus predominantly infects CD4 lymphocytes in vivo, some have assumed that HIV replication directly kills the inf...

journal_title：Current molecular medicine

authors： Cloyd MW,Chen JJ,Adeqboyega P,Wang L

更新日期：2001-11-01 00:00:00

abstract：:Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety of mechanisms are involved in PDAC biological behaviors, of which, the mechanisms of immune escape may be a pivotal hallmark. HLA-G is a tolerant molecule implicated in tumor escape and serves as a prognostic biomarker in ...

journal_title：Current molecular medicine

authors： Xu YF,Lu Y,Cheng H,Jiang J,Xu J,Long J,Liu L,Ni Q,Liu C,Yu XJ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of...

journal_title：Current molecular medicine

authors： Yang H,Jin XJ,Luo H,Li YH

更新日期：2020-01-01 00:00:00

abstract：:Liver cirrhosis, an end-result of a wide variety of the liver diseases, is a world wide health problem. Because of its unique organ system, i.e., portal blood supply, bile formation and enterohepatic circulation, drug metabolism system, and sinusoidal lining cells such as Kupffer, endothelial and stellate cells, the l...

journal_title：Current molecular medicine

authors： Higuchi H,Gores GJ

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

journal_title：Current molecular medicine

authors： Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

更新日期：2014-05-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...

journal_title：Current molecular medicine

authors： Shtrichman R,Germanguz I,Itskovitz-Eldor J

更新日期：2013-06-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disorder (COPD), and cystic fibrosis (CF), chronic diseases of the airways, are characterized by symptoms such as inflammation of the lung tissue, mucus hypersecretion, constriction of the airways, and excessive fibrosis of airway tissue. Transforming growth factor (TGF)-beta, a c...

journal_title：Current molecular medicine

authors： Moore B,Murphy RF,Agrawal DK

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...

journal_title：Current molecular medicine

authors： Hu X,Schewitz-Bowers LP,Lait PJP,Copland DA,Stimpson ML,Li JJ,Liu Y,Dick AD,Lee RWJ,Wei L

更新日期：2018-01-01 00:00:00

abstract：:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...

journal_title：Current molecular medicine

authors： Vasieva O

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Persistent hyperlactatemia is associated with greater mortality in shock. Liver is the main site of lactate metabolism. METHOD:In the first part, freshly isolated hepatocytes were incubated in 10% fetal bovine serum William's E medium supplemented with 10 mM lactate. Cells were then exposed to 100 μM ursode...

journal_title：Current molecular medicine

authors： Wang L,He HW,Zhou X,Long Y

更新日期：2020-01-01 00:00:00

abstract：:The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...

journal_title：Current molecular medicine

authors： Verani A,Lusso P

更新日期：2002-12-01 00:00:00

abstract：:Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...

journal_title：Current molecular medicine

authors： Singer ST,Ataga KI

更新日期：2008-11-01 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：:Skin is a complex tissue composed of two very different compartments -- the continuously renewing epidermis made up mostly by keratinocytes and the underlying matrix-rich dermis with the resting fibroblasts as its major cellular components. Both compartments are tightly interconnected and a paracrine mutual interactio...

journal_title：Current molecular medicine

authors： Boukamp P

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:A small molecular compound, aminooxy-acetic acid (AOA), has been shown to modulate experimental autoimmune encephalomyelitis (EAE). The current study was designed to investigate whether AOA has a similar effect on the development of experimental autoimmune uveitis (EAU) and to further explore underlying mechani...

journal_title：Current molecular medicine

authors： Mei S,Huang Y,Li N,Xu Z,Xu J,Dai Q,Wu J,Kijlstra A,Yang P,Hou S

更新日期：2020-01-01 00:00:00

abstract：:Inhibition of tumor angiogenesis suppresses tumor growth and metastatic spreading in many experimental models, suggesting that anti-angiogenic drugs may be used to treat human cancer. During the past decade more than eighty molecules that showed anti-angiogenic activity in preclinical studies were tested in clinical c...

journal_title：Current molecular medicine

authors： Rüegg C,Meuwly JY,Driscoll R,Werffeli P,Zaman K,Stupp R

更新日期：2003-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...

journal_title：Current molecular medicine

authors： Estep JM,Birerdinc A,Younossi Z

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Overexpression of MDA-9/Syntenin occurs in multiple human cancer cell lines and is associated with higher grade of tumor classification, invasiveness and metastasis. In some cases, its role in cancer biology depends on relationships between MDA-9/Syntenin and NF-κB. OBJECTIVE:This study aims to analyze the ...

journal_title：Current molecular medicine

authors： Notarbartolo M,Labbozzetta M,Pojero F,D'Alessandro N,Poma P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation o...

journal_title：Current molecular medicine

authors： Huang L,Tjakra M,Luo D,Wen L,Lei D,Wang J,Yin T,Zhang X,Huang J,Wang Y,Wang G

更新日期：2019-01-01 00:00:00

abstract：:Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and lysophospholipids. Mammalian PLA2s are divided into two major classes according to their molecular mass and location: intracellular PLA2 a...

journal_title：Current molecular medicine

authors： Touqui L,Alaoui-El-Azher M

更新日期：2001-12-01 00:00:00

abstract：:Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular rem...

journal_title：Current molecular medicine

authors： Filippatos G,Parissis JT,Adamopoulos S,Kardaras F

更新日期：2003-03-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct program...

journal_title：Current molecular medicine

authors： Gu J,Cromer B,Sumer H

更新日期：2020-04-21 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential relationship between the expression levels of GHRH-R and the placental...

journal_title：Current molecular medicine

authors： Liu AX,Zhang D,Zhu YM,Gao HJ,Jiang JY,Hu XL,Lv PP,Leung PC,Huang HF

更新日期：2016-01-01 00:00:00

abstract：:Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

journal_title：Current molecular medicine

authors： Takimoto Y,Inui A,Kumano H,Kuboki T

更新日期：2003-06-01 00:00:00

abstract：:p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...

journal_title：Current molecular medicine

authors： Pellegrini M,Baldari CT

更新日期：2009-04-01 00:00:00