Targeting the process of farynesylation for therapy of hematologic malignancies.

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:Inhibition of tumor angiogenesis suppresses tumor growth and metastatic spreading in many experimental models, suggesting that anti-angiogenic drugs may be used to treat human cancer. During the past decade more than eighty molecules that showed anti-angiogenic activity in preclinical studies were tested in clinical c...

journal_title：Current molecular medicine

authors： Rüegg C,Meuwly JY,Driscoll R,Werffeli P,Zaman K,Stupp R

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:To evaluate cytokine expression profile in aqueous humor and sera in patients with HLAB27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:Twenty patients with AAU and 17 controls were recruited from August 2012 to March 2013. Study subjects with uveitis were divided into two groups: 9 patie...

journal_title：Current molecular medicine

authors： Chen W,Zhao B,Jiang R,Zhang R,Wang Y,Wu H,Gordon L,Chen L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...

journal_title：Current molecular medicine

authors： Hu X,Schewitz-Bowers LP,Lait PJP,Copland DA,Stimpson ML,Li JJ,Liu Y,Dick AD,Lee RWJ,Wei L

更新日期：2018-01-01 00:00:00

abstract：:Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...

journal_title：Current molecular medicine

authors： Maitra A,Wistuba II,Gazdar AF

更新日期：2001-03-01 00:00:00

abstract：:Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...

journal_title：Current molecular medicine

authors： Boyce JA

更新日期：2008-08-01 00:00:00

abstract：:Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

journal_title：Current molecular medicine

authors： Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

更新日期：2007-11-01 00:00:00

abstract：:There has been prolonged and significant interest in manipulating the genome for a wide range of applications in biomedical research and medicine. An existing challenge in realizing this potential has been the inability to precisely edit specific DNA sequences. Past efforts to generate targeted double stranded DNA cle...

journal_title：Current molecular medicine

authors： Go DE,Stottmann RW

更新日期：2016-01-01 00:00:00

abstract：:Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

journal_title：Current molecular medicine

authors： Takimoto Y,Inui A,Kumano H,Kuboki T

更新日期：2003-06-01 00:00:00

abstract：:Many potential HIV vaccine strategies are being explored in both animal model and human settings. The success of any vaccine relies on relevant antigenic determinants being presented to the immune system for the activation of broad and long-lasting immunity. Effective immunity against HIV infection will likely require...

journal_title：Current molecular medicine

authors： Pope M

更新日期：2003-05-01 00:00:00

abstract：:Primary malignancies of the liver and the gastrointestinal tract constitute one of the main health problems worldwide. Together, these types of tumour are the first cause of death due to cancer, followed by lung and breast cancer respectively. One important limitation in the treatment of these tumours is that, with a ...

journal_title：Current molecular medicine

authors： Marin JJ,Romero MR,Martinez-Becerra P,Herraez E,Briz O

更新日期：2009-12-01 00:00:00

abstract：:The purpose of this review is to provide a concise overview of developments over the last 15 years in the field of laboratory tests in human medicine that are based on the detection of alterations in the glycan part of glycoconjugates. We show how glycosylation-based diagnostic testing is widespread in the current cli...

journal_title：Current molecular medicine

authors： Schulz BL,Laroy W,Callewaert N

更新日期：2007-06-01 00:00:00

abstract：:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...

journal_title：Current molecular medicine

authors： Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJ

更新日期：2007-02-01 00:00:00

abstract：:Transcutaneous immunization (TCI) involves the direct application of antigen plus adjuvant to skin, taking advantage of the large numbers of Langerhans cells and other resident skin dendritic cells, that process antigen then migrate to draining lymph nodes where immune responses are initiated. We have used this form o...

journal_title：Current molecular medicine

authors： Hickey DK,Bao S,Ikeda LT,Carey AJ,Beagley KW

更新日期：2005-09-01 00:00:00

abstract：:Mucolipidosis Type IV (MLIV) is a lysosomal storage disorder that is characterized by severe neurologic and ophthalmologic abnormalities. It is a progressive disease that usually presents during the first year of life with mental retardation, corneal opacities, and delayed motor milestones. First described in 1974, ML...

journal_title：Current molecular medicine

authors： Slaugenhaupt SA

更新日期：2002-08-01 00:00:00

abstract：:Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular rem...

journal_title：Current molecular medicine

authors： Filippatos G,Parissis JT,Adamopoulos S,Kardaras F

更新日期：2003-03-01 00:00:00

abstract：:Mood disorders and schizophrenia share a number of common properties, including: genetic susceptibility; differences in brain structure and drug based therapy. Some genetic loci may even confer susceptibility for bipolar mood disorder and schizophrenia, and some atypical antipsychotic drugs are used as mood stabilizer...

journal_title：Current molecular medicine

authors： Harwood AJ

更新日期：2003-08-01 00:00:00

abstract：:p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is ma...

journal_title：Current molecular medicine

authors： Zhang J,Chen X

更新日期：2008-12-01 00:00:00

abstract：:Similar to the human immunodeficiency virus (HIV), the hepatitis B virus (HBV) replicates via reverse transcription, in this case, within infected hepatocytes. Substantial advances have been achieved in the past ten years in developing and utilizing nucleoside/nucleotide analog drugs to inhibit HBV replication. Most a...

journal_title：Current molecular medicine

authors： Yuan HJ,Lee WM

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:15 pati...

journal_title：Current molecular medicine

authors： Zhao B,Zhang S,Chen W,Zhang R,Jiang R,Zhang R,Chen L

更新日期：2018-03-09 00:00:00

abstract：:Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited polycythaemia. VHL disease is a multisystem familial cancer syndrome and is the commonest cause of familial renal cell carcinoma (RCC). VHL disease ...

journal_title：Current molecular medicine

authors： Maher ER

更新日期：2004-12-01 00:00:00

abstract：:Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and lysophospholipids. Mammalian PLA2s are divided into two major classes according to their molecular mass and location: intracellular PLA2 a...

journal_title：Current molecular medicine

authors： Touqui L,Alaoui-El-Azher M

更新日期：2001-12-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of m...

journal_title：Current molecular medicine

authors： Zhang L,Sun J,Liu Z,Dai Y,Luo Z,Jiang X,Li Z,Li Y,Cao P,Zhou Y,Zeng Z,Tang A,Li X,Li X,Xiang J,Li G

更新日期：2014-01-01 00:00:00

abstract：:Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts during development of several cancer types, and therefore emerge as an attractive therapeutic target for cancer therapy. Drugs such as PT-100 and sibrotuzumab that block the functions of CAFs have already been in clinical trials. However, these drugs ex...

journal_title：Current molecular medicine

authors： Xu Y,Zhou X,Mei M,Ren Y

更新日期：2017-01-01 00:00:00

abstract：:Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a n...

journal_title：Current molecular medicine

authors： Crooke ST

更新日期：2004-08-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) and related neuropathies are a genetically highly heterogeneous group of neurodegenerative disorders. CMT affects both the sensory and motor nerves, distal Hereditary Motor Neuropathies (dHMN) are phenotypically similar disorders involving only motor nerves, while Hereditary Sensory a...

journal_title：Current molecular medicine

authors： Pareyson D,Saveri P,Piscosquito G

更新日期：2014-01-01 00:00:00

abstract：:The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has been implicated in various functions, including apop...

journal_title：Current molecular medicine

authors： Veenman L,Gavish M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of...

journal_title：Current molecular medicine

authors： Bieliński M,Lesiewska N,Junik R,Kamińska A,Tretyn A,Borkowska A

更新日期：2019-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the leading causes of blindness in the working population worldwide. Vascular leakage, angiogenesis and neuronal degeneration are key features of DR. Current effective interventions for DR include treatment of systemic risk factors such as elevated blood glucose, blood pressure and ...

journal_title：Current molecular medicine

authors： Zhang X,Wang N,Schachat AP,Bao S,Gillies MC

更新日期：2014-03-01 00:00:00

abstract：:The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulat...

journal_title：Current molecular medicine

authors： Zhang L,Li DW

更新日期：2016-01-01 00:00:00