Abstract:
:Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not been elucidated, it has been reported that high levels of endoglin, a TGF-β auxiliary co-receptor, and a soluble form of this protein, occur respectively in the placenta and plasma of women who develop the disease. In this review, the alterations in vasculogenesis and angiogenesis that occur during preeclampsia, the cellular and molecular mechanisms that lead to increased membrane bound endoglin expression and soluble endoglin release, including hypoxia and oxidative stress, and the possible pathogenic role of soluble endoglin in this disease have been analyzed.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Oujo B,Perez-Barriocanal F,Bernabeu C,Lopez-Novoa JMdoi
10.2174/15665240113139990058subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1345-57issue
8eissn
1566-5240issn
1875-5666pii
CMM-EPUB-04-04-07-2013journal_volume
13pub_type
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