LTP, memory and structural plasticity.

abstract：:Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts during development of several cancer types, and therefore emerge as an attractive therapeutic target for cancer therapy. Drugs such as PT-100 and sibrotuzumab that block the functions of CAFs have already been in clinical trials. However, these drugs ex...

journal_title：Current molecular medicine

authors： Xu Y,Zhou X,Mei M,Ren Y

更新日期：2017-01-01 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：:Pancreatic and duodenal homeobox-1 (PDX-1) is a homeodomain-containing transcription factor that plays a critical role in pancreatic development, β-cell differentiation, maintenance of normal β-cell function and tumorigenesis. PDX-1 is subjected to extensive post-translational modifications for its stability, subcellu...

journal_title：Current molecular medicine

authors： Zhou G,Wang H,Liu SH,Shahi KM,Lin X,Wu J,Feng XH,Qin J,Tan TH,Brunicardi FC

更新日期：2013-03-01 00:00:00

abstract：:Endometriosis is one of the most common gynecological inflammatory diseases, occurring in adolescents and women in the reproductive age group and leading to infertility. The precise etiopathogenesis of endometriosis is unknown, but several theories concerning the phenomena involved in its development have been propose...

journal_title：Current molecular medicine

authors： Zubrzycka A,Zubrzycki M,Janecka A,Zubrzycka M

更新日期：2015-01-01 00:00:00

abstract：:The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various grou...

journal_title：Current molecular medicine

authors： Abdel-Rahman WM,Faris ME,Peltomaki P

更新日期：2017-01-01 00:00:00

abstract：:Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

journal_title：Current molecular medicine

authors： Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

更新日期：2011-08-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, ...

journal_title：Current molecular medicine

authors： Chakraborty C,Shah KD,Cao WG,Hsu CH,Wen ZH,Lin CS

更新日期：2010-11-01 00:00:00

abstract：:Non-invasive energy metabolism measurements in brain tumors in vivo are now performed widely as molecular imaging by positron emission tomography. This capability has developed from a large number of basic and clinical science investigations that have cross fertilized one another. Apart from precise anatomical localiz...

journal_title：Current molecular medicine

authors： Schaller BJ,Cornelius JF,Sandu N,Buchfelder M

更新日期：2008-12-01 00:00:00

abstract：:Similar to the human immunodeficiency virus (HIV), the hepatitis B virus (HBV) replicates via reverse transcription, in this case, within infected hepatocytes. Substantial advances have been achieved in the past ten years in developing and utilizing nucleoside/nucleotide analog drugs to inhibit HBV replication. Most a...

journal_title：Current molecular medicine

authors： Yuan HJ,Lee WM

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine...

journal_title：Current molecular medicine

authors： Cai ZY,Wang CL,Lu TT,Yang WM

更新日期：2019-01-01 00:00:00

abstract：:The identification of a relevant effector of Ran GTPase (Ran) signaling and its pathways could provide a novel approach to cancer therapeutics. With recent research highlighting the significant relationship between Ran expression and the occurrence and progression of cancer, the development of a small molecule compoun...

journal_title：Current molecular medicine

authors： Doherty KJ,McKay C,Chan KK,El-Tanani MK

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

journal_title：Current molecular medicine

authors： Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

更新日期：2020-01-01 00:00:00

abstract：:Maintenance of ex vivo hematopoietic stem cells (HSC) pool and its differentiated progeny is regulated by complex network of transcriptional factors, cell cycle proteins, extracellular matrix, and their microenvironment through an orchestrated fashion. Strides have been made to understand the mechanisms regulating in ...

journal_title：Current molecular medicine

authors： Aggarwal R,Lu J,Pompili VJ,Das H

更新日期：2012-01-01 00:00:00

abstract：:Many autoimmune diseases have genetic associations with the Major Histocompatibility Complex (MHC) class II loci. Susceptibility to Type 1 diabetes mellitus (TIDM) is particularly associated with Human Leucocyte Antigen (HLA) DR3, 4 and associated DQ2, 8 alleles and this is well documented in genetic association studi...

journal_title：Current molecular medicine

authors： Wong FS,Wen L

更新日期：2003-02-01 00:00:00

abstract：:Peroxisomal proliferator activated receptor gamma (PPARgamma) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of target genes. The regulatory role of this receptor on lipid metabolism and insulin sensitization is well established. Recently, the overexpression of this re...

journal_title：Current molecular medicine

authors： Krishnan A,Nair SA,Pillai MR

更新日期：2007-09-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：:There has been prolonged and significant interest in manipulating the genome for a wide range of applications in biomedical research and medicine. An existing challenge in realizing this potential has been the inability to precisely edit specific DNA sequences. Past efforts to generate targeted double stranded DNA cle...

journal_title：Current molecular medicine

authors： Go DE,Stottmann RW

更新日期：2016-01-01 00:00:00

abstract：:Since the discovery almost fifteen years ago that E2F transcription factors are key targets of the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the control of transcription, cell cycle and apoptosis. E2F proteins are encoded by at least eight genes, E2F1 through E2F8. While s...

journal_title：Current molecular medicine

authors： DeGregori J,Johnson DG

更新日期：2006-11-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...

journal_title：Current molecular medicine

authors： Shtrichman R,Germanguz I,Itskovitz-Eldor J

更新日期：2013-06-01 00:00:00

abstract：:Plaque disruption and subsequent thrombus formation play a critical role in the clinical manifestations of atherothrombosis. Vulnerable lesions are characterized by the existence of core rich in lipid, macrophages and tissue factor (TF). Plaque disruption facilitates the interaction between flowing blood with the inne...

journal_title：Current molecular medicine

authors： Viles-Gonzalez JF,Fuster V,Badimon JJ

更新日期：2006-08-01 00:00:00

abstract：:Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism ...

journal_title：Current molecular medicine

authors： Aso Y

更新日期：2008-09-01 00:00:00

abstract：:Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated....

journal_title：Current molecular medicine

authors： Ma H,Sinha B,Pandya RS,Lin N,Popp AJ,Li J,Yao J,Wang X

更新日期：2012-12-01 00:00:00

abstract：:Prostate cancer is one of the most difficult cancers to treat especially when it becomes hormone resistant such as castrate resistant prostate cancer (CRPC) and subsequent metastatic CRPC. Apart from the genetic alterations in prostate cancer, epigenetic modifications also play an important role in the development and...

journal_title：Current molecular medicine

authors： Giudice A,Montella M,Boccellino M,Crispo A,D'Arena G,Bimonte S,Facchini G,Ciliberto G,Botti G,Quagliuolo L,Caraglia M,Capunzo M

更新日期：2017-01-01 00:00:00

abstract：:Nanotechnology has witnessed tremendous advancement over the last several decades. Zinc oxide (ZnO), which can exhibit a wide variety of nanostructures, possesses unique semiconducting, optical, and piezoelectric properties hence has been investigated for a wide variety of applications. The most important features of ...

journal_title：Current molecular medicine

authors： Zhang Y,Nayak TR,Hong H,Cai W

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：:Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria h...

journal_title：Current molecular medicine

authors： Fathizadeh H,Saffari M,Esmaeili D,Moniri R,Kafil HS

更新日期：2020-08-17 00:00:00

abstract：:Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular rem...

journal_title：Current molecular medicine

authors： Filippatos G,Parissis JT,Adamopoulos S,Kardaras F

更新日期：2003-03-01 00:00:00

abstract：:Tumor-derived exosomes contain biological contents such as proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile, studies have shown the role of exosomes in cancer progression, metastasis, and therapeutic resistance. Furthermore, tumor exosomes have received growing attentio...

journal_title：Current molecular medicine

authors： Nooshabadi VT,Arab S

更新日期：2020-11-20 00:00:00

abstract：:The view that mitochondrial electron transport is the only site of aerobic respiration and the primary bioenergetic pathway in mammalian cells is well established in the literature. Although this paradigm is widely accepted for most tissues, the situation is less clear for proliferating cells. Increasing evidence indi...

journal_title：Current molecular medicine

authors： Herst PM,Berridge MV

更新日期：2006-12-01 00:00:00

abstract：:Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

journal_title：Current molecular medicine

authors： Takimoto Y,Inui A,Kumano H,Kuboki T

更新日期：2003-06-01 00:00:00