The molecular basis of mucolipidosis type IV.

abstract：:Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The is...

journal_title：Current molecular medicine

authors： Bertuzzi F,Marzorati S,Secchi A

更新日期：2006-06-01 00:00:00

abstract：:The identification of a relevant effector of Ran GTPase (Ran) signaling and its pathways could provide a novel approach to cancer therapeutics. With recent research highlighting the significant relationship between Ran expression and the occurrence and progression of cancer, the development of a small molecule compoun...

journal_title：Current molecular medicine

authors： Doherty KJ,McKay C,Chan KK,El-Tanani MK

更新日期：2011-11-01 00:00:00

abstract：:Endometriosis is one of the most common gynecological inflammatory diseases, occurring in adolescents and women in the reproductive age group and leading to infertility. The precise etiopathogenesis of endometriosis is unknown, but several theories concerning the phenomena involved in its development have been propose...

journal_title：Current molecular medicine

authors： Zubrzycka A,Zubrzycki M,Janecka A,Zubrzycka M

更新日期：2015-01-01 00:00:00

abstract：:Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a n...

journal_title：Current molecular medicine

authors： Crooke ST

更新日期：2004-08-01 00:00:00

abstract：:The acquisition of cellular immortality is a critical step in human tumorigenesis. While the vast majority of human tumors activate the catalytic component of telomerase (hTERT) to stabilize their telomeres and attain immortality, a significant portion (7-10%) utilize a poorly defined alternative form of telomere main...

journal_title：Current molecular medicine

authors： Stewart SA

更新日期：2005-03-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) and related neuropathies are a genetically highly heterogeneous group of neurodegenerative disorders. CMT affects both the sensory and motor nerves, distal Hereditary Motor Neuropathies (dHMN) are phenotypically similar disorders involving only motor nerves, while Hereditary Sensory a...

journal_title：Current molecular medicine

authors： Pareyson D,Saveri P,Piscosquito G

更新日期：2014-01-01 00:00:00

abstract：:Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...

journal_title：Current molecular medicine

authors： Maitra A,Wistuba II,Gazdar AF

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Protein sumoylation is a well established regulatory mechanism to control many cellular processes such as chromatin structure dynamics, transcriptional regulation of gene expression, cell proliferation and differentiation, cell transformation and carcinogenesis, autophagy and senescence. In the vertebrate visio...

journal_title：Current molecular medicine

authors： Nie Q,Xie J,Gong X,Luo Z,Wang L,Liu F,Xiang JW,Xiao Y,Fu JL,Liu Y,Chen Z,Yang L,Chen H,Gan Y,Li DW

更新日期：2018-01-01 00:00:00

abstract：:Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more ef...

journal_title：Current molecular medicine

authors： Bellati F,Napoletano C,Ruscito I,Visconti V,Antonilli M,Gasparri ML,Zizzari IG,Rahimi H,Palaia I,Rughetti A,Benedetti Panici P,Nuti M

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:A small molecular compound, aminooxy-acetic acid (AOA), has been shown to modulate experimental autoimmune encephalomyelitis (EAE). The current study was designed to investigate whether AOA has a similar effect on the development of experimental autoimmune uveitis (EAU) and to further explore underlying mechani...

journal_title：Current molecular medicine

authors： Mei S,Huang Y,Li N,Xu Z,Xu J,Dai Q,Wu J,Kijlstra A,Yang P,Hou S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology. OBJECTIVES:To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers o...

journal_title：Current molecular medicine

authors： Taha IM,Allah AMA,El Tarhouny S

更新日期：2019-01-01 00:00:00

abstract：:Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

journal_title：Current molecular medicine

authors： Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

更新日期：2012-09-01 00:00:00

abstract：:PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol...

journal_title：Current molecular medicine

authors： De Melo J,He L,Tang D

更新日期：2014-01-01 00:00:00

abstract：:By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Re...

journal_title：Current molecular medicine

authors： Wang Y,Wang XD

更新日期：2015-01-01 00:00:00

abstract：:Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated....

journal_title：Current molecular medicine

authors： Ma H,Sinha B,Pandya RS,Lin N,Popp AJ,Li J,Yao J,Wang X

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of...

journal_title：Current molecular medicine

authors： Yang H,Jin XJ,Luo H,Li YH

更新日期：2020-01-01 00:00:00

abstract：:Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

journal_title：Current molecular medicine

authors： Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

更新日期：2011-08-01 00:00:00

abstract：:Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanis...

journal_title：Current molecular medicine

authors： Mancardi D,Ridnour LA,Thomas DD,Katori T,Tocchetti CG,Espey MG,Miranda KM,Paolocci N,Wink DA

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug. METHODS:In addition, removal of emerging drug contaminants from wastewaters is a necessity that sho...

journal_title：Current molecular medicine

authors： Fu M,Tayebee R,Saberi S,Nourbakhsh N,Esmaeili E,Maleki B,Vatanpour HR

更新日期：2021-01-10 00:00:00

abstract：BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...

journal_title：Current molecular medicine

authors： Hu X,Schewitz-Bowers LP,Lait PJP,Copland DA,Stimpson ML,Li JJ,Liu Y,Dick AD,Lee RWJ,Wei L

更新日期：2018-01-01 00:00:00

abstract：:A major benefit of the genomics revolution in biomedical research has been the establishment of transcriptome analysis as an enabling technology in the drug development process. Nowhere in the realm of drug development has the expectation of the impact of transcriptome analysis been greater than in the area of pre-cli...

journal_title：Current molecular medicine

authors： Searfoss GH,Ryan TP,Jolly RA

更新日期：2005-02-01 00:00:00

abstract：:Tumor-derived exosomes contain biological contents such as proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile, studies have shown the role of exosomes in cancer progression, metastasis, and therapeutic resistance. Furthermore, tumor exosomes have received growing attentio...

journal_title：Current molecular medicine

authors： Nooshabadi VT,Arab S

更新日期：2020-11-20 00:00:00

abstract：:Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...

journal_title：Current molecular medicine

authors： Pezzini A,Del Zotto E,Giossi A,Volonghi I,Grassi M,Padovani A

更新日期：2009-03-01 00:00:00

abstract：:Antibody targeted cytoplasmic delivery of drugs is difficult to achieve as antigen-antibody interaction results in the payload being directed to the endosomal compartment. However, Sendai viral envelopes can bring about cytoplasmic delivery due to F-protein mediated membrane fusion. In this study we have generated and...

journal_title：Current molecular medicine

authors： Kumar M,Mani P,Pratheesh P,Chandra S,Jeyakkodi M,Chattopadhyay P,Sarkar DP,Sinha S

更新日期：2015-01-01 00:00:00

abstract：:Spider venom is a large pharmacological repertoire containing many biologically active peptides, which may have a potent therapeutic implication. Here we investigated a peptide toxin, named lycosin-I, isolated from the venom of the spider Lycosa singoriensis. In contrast to most spider peptide toxins adopting inhibito...

journal_title：Current molecular medicine

authors： Liu Z,Deng M,Xiang J,Ma H,Hu W,Zhao Y,Li DW,Liang S

更新日期：2012-12-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00

abstract：:Nanotechnology has witnessed tremendous advancement over the last several decades. Zinc oxide (ZnO), which can exhibit a wide variety of nanostructures, possesses unique semiconducting, optical, and piezoelectric properties hence has been investigated for a wide variety of applications. The most important features of ...

journal_title：Current molecular medicine

authors： Zhang Y,Nayak TR,Hong H,Cai W

更新日期：2013-12-01 00:00:00

abstract：:Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

journal_title：Current molecular medicine

authors： Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

更新日期：2007-11-01 00:00:00

abstract：:The ocular lens is a non-vascular and non-innervated transparent organ that plays an important role in vision processing. This unique organ is derived from the embryonic ectoderm of the brain region through a complicated differentiation process in which apoptosis plays a key role. First, when the committed ectoderm be...

journal_title：Current molecular medicine

authors： Zhang L,Yan Q,Liu JP,Zou LJ,Liu J,Sun S,Deng M,Gong L,Ji WK,Li DW

更新日期：2010-12-01 00:00:00