The role of transcriptome analysis in pre-clinical toxicology.

abstract：BACKGROUND:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of...

journal_title：Current molecular medicine

authors： Bieliński M,Lesiewska N,Junik R,Kamińska A,Tretyn A,Borkowska A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of...

journal_title：Current molecular medicine

authors： Yang H,Jin XJ,Luo H,Li YH

更新日期：2020-01-01 00:00:00

abstract：:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...

journal_title：Current molecular medicine

authors： Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJ

更新日期：2007-02-01 00:00:00

abstract：:The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retina...

journal_title：Current molecular medicine

authors： Tolentino MJ

更新日期：2009-11-01 00:00:00

abstract：:In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...

journal_title：Current molecular medicine

authors： Pan J,Liu H,Zhou J,Liu Z,Yang Y,Peng Y,You H,Yang D,Xie P

更新日期：2014-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...

journal_title：Current molecular medicine

authors： Estep JM,Birerdinc A,Younossi Z

更新日期：2010-03-01 00:00:00

abstract：:WHIM syndrome is a dominantly inherited primary immunodeficiency disorder representing the first identified example of human disease caused by mutations in the gene encoding for the chemokine receptor CXCR4. Pathogenesis is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL1...

journal_title：Current molecular medicine

authors： Dotta L,Tassone L,Badolato R

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Overexpression of MDA-9/Syntenin occurs in multiple human cancer cell lines and is associated with higher grade of tumor classification, invasiveness and metastasis. In some cases, its role in cancer biology depends on relationships between MDA-9/Syntenin and NF-κB. OBJECTIVE:This study aims to analyze the ...

journal_title：Current molecular medicine

authors： Notarbartolo M,Labbozzetta M,Pojero F,D'Alessandro N,Poma P

更新日期：2018-01-01 00:00:00

abstract：:HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1-ind...

journal_title：Current molecular medicine

authors： Rauvala H,Rouhiainen A

更新日期：2007-12-01 00:00:00

abstract：:As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobuli...

journal_title：Current molecular medicine

authors： Allen RL,Trowsdale J

更新日期：2004-02-01 00:00:00

abstract：:Many potential HIV vaccine strategies are being explored in both animal model and human settings. The success of any vaccine relies on relevant antigenic determinants being presented to the immune system for the activation of broad and long-lasting immunity. Effective immunity against HIV infection will likely require...

journal_title：Current molecular medicine

authors： Pope M

更新日期：2003-05-01 00:00:00

abstract：:Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...

journal_title：Current molecular medicine

authors： Yamaguchi M,Vikulina T,Arbiser JL,Weitzmann MN

更新日期：2014-01-01 00:00:00

abstract：:The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a cancer cell-specific pro-apoptotic activity. This property made the TRAIL associated pathway one of the most promising strategies aimed at inducing tumor-selective death. In fact, several approaches have been considered to explore this pathwa...

journal_title：Current molecular medicine

authors： De Carvalho DD,Mello BP,Pereira WO,Amarante-Mendes GP

更新日期：2013-02-01 00:00:00

abstract：:HIV infection causes an acquired immunodeficiency, principally because of depletion of CD4 lymphocytes. The mechanism by which the virus depletes these cells, however, is not clearly understood. Since the virus predominantly infects CD4 lymphocytes in vivo, some have assumed that HIV replication directly kills the inf...

journal_title：Current molecular medicine

authors： Cloyd MW,Chen JJ,Adeqboyega P,Wang L

更新日期：2001-11-01 00:00:00

abstract：:Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...

journal_title：Current molecular medicine

authors： Singer ST,Ataga KI

更新日期：2008-11-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00

abstract：:The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...

journal_title：Current molecular medicine

authors： Verani A,Lusso P

更新日期：2002-12-01 00:00:00

abstract：:Inhibition of tumor angiogenesis suppresses tumor growth and metastatic spreading in many experimental models, suggesting that anti-angiogenic drugs may be used to treat human cancer. During the past decade more than eighty molecules that showed anti-angiogenic activity in preclinical studies were tested in clinical c...

journal_title：Current molecular medicine

authors： Rüegg C,Meuwly JY,Driscoll R,Werffeli P,Zaman K,Stupp R

更新日期：2003-12-01 00:00:00

abstract：:Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...

journal_title：Current molecular medicine

authors： Be NA,Kim KS,Bishai WR,Jain SK

更新日期：2009-03-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...

journal_title：Current molecular medicine

authors： Shtrichman R,Germanguz I,Itskovitz-Eldor J

更新日期：2013-06-01 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen, which is the cause of a tick-borne illness occurring in many areas of Africa, Asia, and Europe. CCHF is characterized by a sudden onset of high fever, chills, and severe headache. Other symptoms can include gastrointestinal disorders, such a...

journal_title：Current molecular medicine

authors： Flick R,Whitehouse CA

更新日期：2005-12-01 00:00:00

abstract：:Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential relationship between the expression levels of GHRH-R and the placental...

journal_title：Current molecular medicine

authors： Liu AX,Zhang D,Zhu YM,Gao HJ,Jiang JY,Hu XL,Lv PP,Leung PC,Huang HF

更新日期：2016-01-01 00:00:00

abstract：:Tumor-derived exosomes contain biological contents such as proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile, studies have shown the role of exosomes in cancer progression, metastasis, and therapeutic resistance. Furthermore, tumor exosomes have received growing attentio...

journal_title：Current molecular medicine

authors： Nooshabadi VT,Arab S

更新日期：2020-11-20 00:00:00

abstract：:p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...

journal_title：Current molecular medicine

authors： Pellegrini M,Baldari CT

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper imm...

journal_title：Current molecular medicine

authors： Zou Y,Chen Q,Ye Z,Li X,Ju R

更新日期：2017-12-07 00:00:00

abstract：:Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elici...

journal_title：Current molecular medicine

authors： Multhoff G,Pockley AG,Streffer C,Gaipl US

更新日期：2012-11-01 00:00:00

abstract：:Mood disorders and schizophrenia share a number of common properties, including: genetic susceptibility; differences in brain structure and drug based therapy. Some genetic loci may even confer susceptibility for bipolar mood disorder and schizophrenia, and some atypical antipsychotic drugs are used as mood stabilizer...

journal_title：Current molecular medicine

authors： Harwood AJ

更新日期：2003-08-01 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：:Transcutaneous immunization (TCI) involves the direct application of antigen plus adjuvant to skin, taking advantage of the large numbers of Langerhans cells and other resident skin dendritic cells, that process antigen then migrate to draining lymph nodes where immune responses are initiated. We have used this form o...

journal_title：Current molecular medicine

authors： Hickey DK,Bao S,Ikeda LT,Carey AJ,Beagley KW

更新日期：2005-09-01 00:00:00