Biomedical applications of zinc oxide nanomaterials.

abstract：:Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...

journal_title：Current molecular medicine

authors： Boyce JA

更新日期：2008-08-01 00:00:00

abstract：:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...

journal_title：Current molecular medicine

authors： Vasieva O

更新日期：2011-03-01 00:00:00

abstract：:Transcutaneous immunization (TCI) involves the direct application of antigen plus adjuvant to skin, taking advantage of the large numbers of Langerhans cells and other resident skin dendritic cells, that process antigen then migrate to draining lymph nodes where immune responses are initiated. We have used this form o...

journal_title：Current molecular medicine

authors： Hickey DK,Bao S,Ikeda LT,Carey AJ,Beagley KW

更新日期：2005-09-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：:In 1968 Berger and Hinglais published the first description of IgA nephropathy (IgAN). In the ensuing 30 years, extensive clinical, epidemiologic, and immunologic characterizations of primary (idiopathic) glomerulonephritis with IgA as the predominant or co-dominant immunoglobulin deposited in the mesangia of all glom...

journal_title：Current molecular medicine

authors： Hsu SI

更新日期：2001-05-01 00:00:00

abstract：:PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol...

journal_title：Current molecular medicine

authors： De Melo J,He L,Tang D

更新日期：2014-01-01 00:00:00

abstract：:Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not be...

journal_title：Current molecular medicine

authors： Oujo B,Perez-Barriocanal F,Bernabeu C,Lopez-Novoa JM

更新日期：2013-09-01 00:00:00

abstract：:Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular rem...

journal_title：Current molecular medicine

authors： Filippatos G,Parissis JT,Adamopoulos S,Kardaras F

更新日期：2003-03-01 00:00:00

abstract：:The generation of functional neural progenitor cells (NPCs) independent of donor brain tissue and embryonic tissues is of great therapeutic interest with regard to regenerative medicine and the possible treatment of neurodegenerative disorders. Traditionally, NPCs are derived through the differentiation of embryonic s...

journal_title：Current molecular medicine

authors： Tian C,Ambroz RJ,Sun L,Wang Y,Ma K,Chen Q,Zhu B,Zheng JC

更新日期：2012-02-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by st...

journal_title：Current molecular medicine

authors： Zhang RL,Zhang ZG,Chopp M

更新日期：2007-08-01 00:00:00

abstract：:Most lysosomal storage diseases (LSD) exhibit neurological symptoms and there has been limited success in their treatment. Innovative treatments employing novel therapy or gene therapy may offer the prospect of improvement. Recent attempts to treat the neurological forms of LSD include neural stem cell therapy, mesenc...

journal_title：Current molecular medicine

authors： Eto Y,Ohashi T

更新日期：2002-02-01 00:00:00

abstract：:The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulat...

journal_title：Current molecular medicine

authors： Zhang L,Li DW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Seven isoforms of histone deacetylase Class III have been reported - Sirtuin (SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligationand- puncture (CLP)-induced septic shock. Our present study was aimed at determining whether selecti...

journal_title：Current molecular medicine

authors： Zhao T,Alam HB,Liu B,Bronson RT,Nikolian VC,Wu E,Chong W,Li Y

更新日期：2015-01-01 00:00:00

abstract：:Autophagy is a bulk cytosolic degradative process which in the last few years has become a key pathway for the advancement of molecular medicine. Autophagy (cellular self-eating) has several implications in human disorders involving accumulation of cytosolic protein aggregates such as Alzheimer, Parkinson, Huntington ...

journal_title：Current molecular medicine

authors： Lerena C,Calligaris SD,Colombo MI

更新日期：2008-03-01 00:00:00

abstract：:Primary malignancies of the liver and the gastrointestinal tract constitute one of the main health problems worldwide. Together, these types of tumour are the first cause of death due to cancer, followed by lung and breast cancer respectively. One important limitation in the treatment of these tumours is that, with a ...

journal_title：Current molecular medicine

authors： Marin JJ,Romero MR,Martinez-Becerra P,Herraez E,Briz O

更新日期：2009-12-01 00:00:00

abstract：:Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...

journal_title：Current molecular medicine

authors： Maitra A,Wistuba II,Gazdar AF

更新日期：2001-03-01 00:00:00

abstract：:Conformational or misfolding diseases are a large class of devastating human disorders associated with protein misfolding and aggregation. Most conformational diseases are caused by a combination of genetic and environmental factors, suggesting that spontaneous events can destabilize the protein involved in the pathol...

journal_title：Current molecular medicine

authors： Cardinale A,Biocca S

更新日期：2008-02-01 00:00:00

abstract：:Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty ...

journal_title：Current molecular medicine

authors： Fang EF,Ng TB

更新日期：2011-07-01 00:00:00

abstract：:Despite advances in biomedical sciences, the prognosis of patients with brain tumors remains poor. Effective treatment is lacking for these central nervous system (CNS) cancers. Targeted immunotoxins are a new class of therapeutic approaches that have emerged for the treatment of human cancers. In this approach, tumor...

journal_title：Current molecular medicine

authors： Puri S,Puri S,Mahapatra AK,Hussain E,Sarkar C,Sinha S,Joshi BH

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:15 pati...

journal_title：Current molecular medicine

authors： Zhao B,Zhang S,Chen W,Zhang R,Jiang R,Zhang R,Chen L

更新日期：2018-03-09 00:00:00

abstract：:p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is ma...

journal_title：Current molecular medicine

authors： Zhang J,Chen X

更新日期：2008-12-01 00:00:00

abstract：:Type 2 diabetes carries a 2-6-fold increased risk of cardiovascular disease (CVD) and death. Indeed, the risk of major cardiovascular events in Type 2 diabetic patients without history of coronary heart disease (CHD) is equivalent to that observed in non-diabetic subjects with CHD. However, atherosclerosis may also pr...

journal_title：Current molecular medicine

authors： Ziegler D

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine...

journal_title：Current molecular medicine

authors： Cai ZY,Wang CL,Lu TT,Yang WM

更新日期：2019-01-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:The blood stage of the malaria parasite's life cycle is responsible for all the clinical symptoms of malaria. The development of clinical disease is dependent on the interplay of the infecting parasite with the immune status and genetic background of the host. Following repeated exposure to malaria parasites, individu...

journal_title：Current molecular medicine

authors： Yazdani SS,Mukherjee P,Chauhan VS,Chitnis CE

更新日期：2006-03-01 00:00:00

abstract：:Deregulation of the PI3K pathway is common in human cancer. The basic players in this pathway are the kinases PI3K and AKT and the phosphatase PTEN. This review will summarize some of the key animal models that have helped us understand this signaling network and its contribution to tumorigenesis. Recently, great adva...

journal_title：Current molecular medicine

authors： Renner O,Carnero A

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

journal_title：Current molecular medicine

authors： Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation o...

journal_title：Current molecular medicine

authors： Huang L,Tjakra M,Luo D,Wen L,Lei D,Wang J,Yin T,Zhang X,Huang J,Wang Y,Wang G

更新日期：2019-01-01 00:00:00

abstract：:Human genetic data on psychiatric disorders repeatedly demonstrate the involvement of various genes that are associated with neural development and neurogenesis. Neurogenesis is a biological process that is critical in brain development and continues throughout life. Neurogenesis is a multi-step process starting from ...

journal_title：Current molecular medicine

authors： Osumi N,Guo N,Matsumata M,Yoshizaki K

更新日期：2015-01-01 00:00:00