Abstract:
:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It also was shown to bind proteins and compounds containing iron and nitric oxide. Some of these interactions have developed in the course of evolution into regulatory pathways that back up the GST's most ancient catalytic functions and provide precise and diverse responses to chemical and redox stresses. An aim of this review is to summarise recent knowledge on GSTP's complementary functions in crosstalking pathways of conventional glutathione transfer, nitric oxide and lipid metabolism and ASK1-dependent stress response. This review will describe how these complex interactions affect regulation of cell respiration, biosynthesis of lung surfactant, organism's immunity and circadian rhythms. Integration of the data leads to a new interpretation of the role of GSTP in normal human physiology, pathology and an organism's susceptibility to diseases.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Vasieva Odoi
10.2174/156652411794859278subject
Has Abstractpub_date
2011-03-01 00:00:00pages
129-39issue
2eissn
1566-5240issn
1875-5666pii
CMM # 93journal_volume
11pub_type
杂志文章,评审abstract::Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elici...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652412803306666
更新日期:2012-11-01 00:00:00
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journal_title:Current molecular medicine
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pub_type: 杂志文章,评审
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2012-12-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2004-02-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2002-02-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524016666151123104855
更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652411798062421
更新日期:2011-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524013666131118114432
更新日期:2014-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2014-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524011009060550
更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-11-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524020999200817113730
更新日期:2020-08-17 00:00:00
abstract:BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524018666180308113909
更新日期:2017-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2015-01-01 00:00:00
abstract::The cell adhesion molecule integrin αvβ3 is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin αvβ3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652406776894536
更新日期:2006-05-01 00:00:00