Abstract:
:Enteroviruses are common human pathogens involved in a wide spectrum of clinical outcomes ranging from mild or non-symptomatic illness to severe diseases with neurological and/or cardiac manifestation. Despite being responsible for significant morbidity and mortality especially in immunocompromised patients and infants, to date no effective vaccines or specific antiviral treatment modalities are available to prevent or treat non-polio enteroviral infections. The discovery of the endogenous RNA interference pathway as an innate defence mechanism conferring intracellular immunity against foreign genetic elements has provided exciting possibilities in the fight against so far intractable, enteroviral diseases. We and others have shown the encouraging potential of RNA interference to limit enteroviral infections, leading to significant suppression of viral replication and cytopathogenicity, in vitro as well as in vivo. Yet, considerable limitations concerning efficacy, stability, specificity as well as viral escape need to be addressed to translate the anti-enteroviral potential into a novel treatment modality.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Schönhofer-Merl S,Wessely Rdoi
10.2174/1566524011009060550subject
Has Abstractpub_date
2010-08-01 00:00:00pages
550-64issue
6eissn
1566-5240issn
1875-5666pii
CMM # 59journal_volume
10pub_type
杂志文章,评审abstract::The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a cancer cell-specific pro-apoptotic activity. This property made the TRAIL associated pathway one of the most promising strategies aimed at inducing tumor-selective death. In fact, several approaches have been considered to explore this pathwa...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 信件
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
abstract::Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...
journal_title:Current molecular medicine
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更新日期:2001-03-01 00:00:00
abstract::Many autoimmune diseases have genetic associations with the Major Histocompatibility Complex (MHC) class II loci. Susceptibility to Type 1 diabetes mellitus (TIDM) is particularly associated with Human Leucocyte Antigen (HLA) DR3, 4 and associated DQ2, 8 alleles and this is well documented in genetic association studi...
journal_title:Current molecular medicine
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更新日期:2003-02-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652406776894536
更新日期:2006-05-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2005-05-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2016-01-01 00:00:00
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journal_title:Current molecular medicine
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doi:10.2174/1566524019666190104105043
更新日期:2018-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652408786733766
更新日期:2008-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) provides unique machinery for the folding and posttranslational modification of many secretory and transmembrane proteins in eukaryotic cells. The unfolded protein response (UPR) is a signal transduction network from the ER to the nucleus activated when the folding demand imposed by nasc...
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pub_type: 杂志文章,评审
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更新日期:2006-02-01 00:00:00
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更新日期:2011-12-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2004-11-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2003-12-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2009-02-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
abstract::In 1968 Berger and Hinglais published the first description of IgA nephropathy (IgAN). In the ensuing 30 years, extensive clinical, epidemiologic, and immunologic characterizations of primary (idiopathic) glomerulonephritis with IgA as the predominant or co-dominant immunoglobulin deposited in the mesangia of all glom...
journal_title:Current molecular medicine
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更新日期:2001-05-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
abstract::In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666141021143333
更新日期:2014-01-01 00:00:00