Bacteriocins: New Potential Therapeutic Candidates in Cancer Therapy.

Abstract:

:Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria has emerged as new therapeutic approaches in the treatment of various cancers. Increasing data indicated that bacteria could be used in the production of a wide range of anti-cancer agents including bacteriocins, antibiotics, peptides, enzymes, and toxins. Among these anti-cancer agents, bacteriocins have attractive properties which make them as powerful anti-cancer drugs. Multiple lines evidence indicated that several bacteriocins (i.e. colcins, nisins, pediocins, pyocins, and bovocins) via activation/inhibition different cellular and molecular signaling pathways are able to suppress tumor growth in various stages. Hence, identification and using various bacteriocins could lead to improve and introduce them to clinical practices. Here, we summarized various bacteriocins which could be employed as anti-cancer agents in the treatment of many cancers.

journal_name

Curr Mol Med

authors

Fathizadeh H,Saffari M,Esmaeili D,Moniri R,Kafil HS

doi

10.2174/1566524020999200817113730

subject

Has Abstract

pub_date

2020-08-17 00:00:00

eissn

1566-5240

issn

1875-5666

pii

CMM-EPUB-109149

pub_type

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