PRAME/EZH2-mediated regulation of TRAIL: a new target for cancer therapy.

abstract：:Liver cirrhosis, an end-result of a wide variety of the liver diseases, is a world wide health problem. Because of its unique organ system, i.e., portal blood supply, bile formation and enterohepatic circulation, drug metabolism system, and sinusoidal lining cells such as Kupffer, endothelial and stellate cells, the l...

journal_title：Current molecular medicine

authors： Higuchi H,Gores GJ

更新日期：2003-09-01 00:00:00

abstract：:Several species of kinetoplastid protozoa cause major human infectious diseases. Trypanosoma cruzi is responsible for the fatal Chagas disease in large parts of South America, the various species of Leishmania cause a number of different human diseases with millions of patients world-wide, and the African trypanosome ...

journal_title：Current molecular medicine

authors： Seebeck T,Schaub R,Johner A

更新日期：2004-09-01 00:00:00

abstract：:Pancreatic and duodenal homeobox-1 (PDX-1) is a homeodomain-containing transcription factor that plays a critical role in pancreatic development, β-cell differentiation, maintenance of normal β-cell function and tumorigenesis. PDX-1 is subjected to extensive post-translational modifications for its stability, subcellu...

journal_title：Current molecular medicine

authors： Zhou G,Wang H,Liu SH,Shahi KM,Lin X,Wu J,Feng XH,Qin J,Tan TH,Brunicardi FC

更新日期：2013-03-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00

abstract：:Since the discovery almost fifteen years ago that E2F transcription factors are key targets of the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the control of transcription, cell cycle and apoptosis. E2F proteins are encoded by at least eight genes, E2F1 through E2F8. While s...

journal_title：Current molecular medicine

authors： DeGregori J,Johnson DG

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacifi...

journal_title：Current molecular medicine

authors： Bao X,Hou M,Peng R,Luo F,Wu M

更新日期：2017-01-01 00:00:00

abstract：:The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...

journal_title：Current molecular medicine

authors： Verani A,Lusso P

更新日期：2002-12-01 00:00:00

abstract：:Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

journal_title：Current molecular medicine

authors： Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

更新日期：2012-09-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and g...

journal_title：Current molecular medicine

authors： Kovacs Z,Guttman A

更新日期：2018-01-01 00:00:00

abstract：:Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

journal_title：Current molecular medicine

authors： Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

更新日期：2007-11-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:The cell adhesion molecule integrin αvβ3 is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin αvβ3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) ...

journal_title：Current molecular medicine

authors： Liu Z,Wang F

更新日期：2013-12-01 00:00:00

abstract：:Maintenance of ex vivo hematopoietic stem cells (HSC) pool and its differentiated progeny is regulated by complex network of transcriptional factors, cell cycle proteins, extracellular matrix, and their microenvironment through an orchestrated fashion. Strides have been made to understand the mechanisms regulating in ...

journal_title：Current molecular medicine

authors： Aggarwal R,Lu J,Pompili VJ,Das H

更新日期：2012-01-01 00:00:00

abstract：:HIV infection causes an acquired immunodeficiency, principally because of depletion of CD4 lymphocytes. The mechanism by which the virus depletes these cells, however, is not clearly understood. Since the virus predominantly infects CD4 lymphocytes in vivo, some have assumed that HIV replication directly kills the inf...

journal_title：Current molecular medicine

authors： Cloyd MW,Chen JJ,Adeqboyega P,Wang L

更新日期：2001-11-01 00:00:00

abstract：:Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism ...

journal_title：Current molecular medicine

authors： Aso Y

更新日期：2008-09-01 00:00:00

abstract：:Despite advances in biomedical sciences, the prognosis of patients with brain tumors remains poor. Effective treatment is lacking for these central nervous system (CNS) cancers. Targeted immunotoxins are a new class of therapeutic approaches that have emerged for the treatment of human cancers. In this approach, tumor...

journal_title：Current molecular medicine

authors： Puri S,Puri S,Mahapatra AK,Hussain E,Sarkar C,Sinha S,Joshi BH

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The phenotypic severity of β-thalassemia is highly modulated by three genetic modifiers: β-globin (HBB) mutations, co-inheritance of α-thalassemia and polymorphisms in the genes associated with fetal haemoglobin (HbF) production. This study was aimed to evaluate the effect of HbF related polymorphisms mainly...

journal_title：Current molecular medicine

authors： Razak SAA,Murad NAA,Masra F,Chong DLS,Abdullah N,Jalil N,Alauddin H,Sabudin RZAR,Ithnin A,Khai LC,Aziz NA,Muda Z,Ibrahim H,Latiff ZA

更新日期：2018-01-01 00:00:00

abstract：:Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

journal_title：Current molecular medicine

authors： Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

更新日期：2011-08-01 00:00:00

abstract：:Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The is...

journal_title：Current molecular medicine

authors： Bertuzzi F,Marzorati S,Secchi A

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Plasmid DNA has been widely used in vaccination as well as in cell and gene therapy. It exists in multiple isoforms, including supercoiled, nicked or open circular and linear forms. Regulatory agencies recommend having more than 80% of the supercoiled isoform for the bulk release of plasmid products; thus, i...

journal_title：Current molecular medicine

authors： Cook KS,Luo J,Guttman A,Thompson L

更新日期：2020-04-27 00:00:00

abstract：:As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobuli...

journal_title：Current molecular medicine

authors： Allen RL,Trowsdale J

更新日期：2004-02-01 00:00:00

abstract：:Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as ant...

journal_title：Current molecular medicine

authors： Caruso R,Stolfi C,De Nitto D,Pallone F,Monteleone G

更新日期：2011-02-01 00:00:00

abstract：:The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study...

journal_title：Current molecular medicine

authors： Zhong L,Tang J,Kong QP,Sun C,Zhou WP,Yang M,Yao YG,Zhang YP

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...

journal_title：Current molecular medicine

authors： Zhang M,Chen L,Xu F,Jiang L,Yan W,Kunwar B,Tang F,Yang K,Shen C,Huang H,Lv J,Qin C,Wu X,Zeng S,Li M,Zhong S,Chen Q

更新日期：2019-01-01 00:00:00

abstract：:Although it has been known for long time that atherosclerosis is associated with lipid deposition, only recently it has been accepted that the plasmatic concentration of cholesterol, especially LDL cholesterol, is a risk factor for atherosclerosis. However, chemically modified LDL, but not native LDL, is able to induc...

journal_title：Current molecular medicine

authors： Albertini R,Moratti R,De Luca G

更新日期：2002-09-01 00:00:00

abstract：:A critical challenge faced by clinical nephrologists today is the escalating number of patients developing end stage renal disease, a major proportion of which is attributed to diabetic nephropathy (DN). The need for new measures to prevent and treat this disease cannot be overemphasized. To this end, modern genetic a...

journal_title：Current molecular medicine

authors： Ng DP,Krolewski AS

更新日期：2005-08-01 00:00:00

abstract：:Endometriosis is one of the most common gynecological inflammatory diseases, occurring in adolescents and women in the reproductive age group and leading to infertility. The precise etiopathogenesis of endometriosis is unknown, but several theories concerning the phenomena involved in its development have been propose...

journal_title：Current molecular medicine

authors： Zubrzycka A,Zubrzycki M,Janecka A,Zubrzycka M

更新日期：2015-01-01 00:00:00

abstract：:Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...

journal_title：Current molecular medicine

authors： Yamaguchi M,Vikulina T,Arbiser JL,Weitzmann MN

更新日期：2014-01-01 00:00:00

abstract：:Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria h...

journal_title：Current molecular medicine

authors： Fathizadeh H,Saffari M,Esmaeili D,Moniri R,Kafil HS

更新日期：2020-08-17 00:00:00

abstract：:Nanotechnology has witnessed tremendous advancement over the last several decades. Zinc oxide (ZnO), which can exhibit a wide variety of nanostructures, possesses unique semiconducting, optical, and piezoelectric properties hence has been investigated for a wide variety of applications. The most important features of ...

journal_title：Current molecular medicine

authors： Zhang Y,Nayak TR,Hong H,Cai W

更新日期：2013-12-01 00:00:00