Cardiovascular disease in patients with diabetic nephropathy.

abstract：:HIV infection causes an acquired immunodeficiency, principally because of depletion of CD4 lymphocytes. The mechanism by which the virus depletes these cells, however, is not clearly understood. Since the virus predominantly infects CD4 lymphocytes in vivo, some have assumed that HIV replication directly kills the inf...

journal_title：Current molecular medicine

authors： Cloyd MW,Chen JJ,Adeqboyega P,Wang L

更新日期：2001-11-01 00:00:00

abstract：:As tumors progress to increased malignancy, cells within them develop the ability to invade into surrounding normal tissues and through tissue boundaries to form new growths (metastases) at sites distinct from the primary tumor. The molecular mechanisms involved in this process are incompletely understood but those as...

journal_title：Current molecular medicine

authors： Cairns RA,Khokha R,Hill RP

更新日期：2003-11-01 00:00:00

abstract：:Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The is...

journal_title：Current molecular medicine

authors： Bertuzzi F,Marzorati S,Secchi A

更新日期：2006-06-01 00:00:00

abstract：:Our current understanding of the mechanisms of information processing and storage in the brain, based on the concept proposed more than fifty years ago by D. Hebb, is that a key role is played by changes in synaptic efficacy induced by coincident pre- and postsynaptic activity. Decades of studies of the properties of ...

journal_title：Current molecular medicine

authors： Muller D,Nikonenko I,Jourdain P,Alberi S

更新日期：2002-11-01 00:00:00

abstract：:Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...

journal_title：Current molecular medicine

authors： Pezzini A,Del Zotto E,Giossi A,Volonghi I,Grassi M,Padovani A

更新日期：2009-03-01 00:00:00

abstract：:Mistletoe is often used as complementary therapy in oncology. The anti-tumor effects of mistletoe (Iscador) are well documented in-vitro in respect to inhibition of cell proliferation, induction of apoptosis, segmental activation of immune competent cells and trapping of chemotherapeutic drugs within cancer cells by m...

journal_title：Current molecular medicine

authors： Matthes H,Friedel WE,Bock PR,Zänker KS

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine...

journal_title：Current molecular medicine

authors： Cai ZY,Wang CL,Lu TT,Yang WM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear. METHODS AND RESULTS:This study investigates the effects of LA on...

journal_title：Current molecular medicine

authors： Yang Y,Huang J,Li J,Yang H,Yin Y

更新日期：2020-01-01 00:00:00

abstract：:Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated....

journal_title：Current molecular medicine

authors： Ma H,Sinha B,Pandya RS,Lin N,Popp AJ,Li J,Yao J,Wang X

更新日期：2012-12-01 00:00:00

abstract：:The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has been implicated in various functions, including apop...

journal_title：Current molecular medicine

authors： Veenman L,Gavish M

更新日期：2012-05-01 00:00:00

abstract：:Skin is a complex tissue composed of two very different compartments -- the continuously renewing epidermis made up mostly by keratinocytes and the underlying matrix-rich dermis with the resting fibroblasts as its major cellular components. Both compartments are tightly interconnected and a paracrine mutual interactio...

journal_title：Current molecular medicine

authors： Boukamp P

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...

journal_title：Current molecular medicine

authors： Zhang M,Chen L,Xu F,Jiang L,Yan W,Kunwar B,Tang F,Yang K,Shen C,Huang H,Lv J,Qin C,Wu X,Zeng S,Li M,Zhong S,Chen Q

更新日期：2019-01-01 00:00:00

abstract：:After several years of controversy, antibodies (Abs) are now believed to play an important role in the protection against fungal infections. Among them, recent data are strongly supporting the relevance of protective yeast killer toxin-like Abs ("antibiobodies", KT-Abs), which are able to exert a direct microbicidal a...

journal_title：Current molecular medicine

authors： Magliani W,Conti S,Frazzi R,Ravanetti L,Maffei DL,Polonelli L

更新日期：2005-06-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have become increasingly widely used to determine regions of the genome which may contain loci influencing the risk of neurological disorders. While linkage studies have identified genes that cause a number of Mendelian disorders, linkage analysis is less well suited for the more...

journal_title：Current molecular medicine

authors： Gubitz AK,Gwinn K

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：:There has been prolonged and significant interest in manipulating the genome for a wide range of applications in biomedical research and medicine. An existing challenge in realizing this potential has been the inability to precisely edit specific DNA sequences. Past efforts to generate targeted double stranded DNA cle...

journal_title：Current molecular medicine

authors： Go DE,Stottmann RW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...

journal_title：Current molecular medicine

authors： Chen F,Yuan W,Mo X,Zhuang J,Wang Y,Chen J,Jiang Z,Zhu X,Zeng Q,Wan Y,Li F,Shi Y,Cao L,Fan X,Luo S,Ye X,Chen Y,Dai G,Gao J,Wang X,Xie H,Zhu P,Li Y,Wu X

更新日期：2017-01-01 00:00:00

abstract：:Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a n...

journal_title：Current molecular medicine

authors： Crooke ST

更新日期：2004-08-01 00:00:00

abstract：:Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

journal_title：Current molecular medicine

authors： Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

更新日期：2012-09-01 00:00:00

abstract：:The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...

journal_title：Current molecular medicine

authors： Verani A,Lusso P

更新日期：2002-12-01 00:00:00

abstract：:Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanis...

journal_title：Current molecular medicine

authors： Mancardi D,Ridnour LA,Thomas DD,Katori T,Tocchetti CG,Espey MG,Miranda KM,Paolocci N,Wink DA

更新日期：2004-11-01 00:00:00

abstract：:The world is aging and we must face the challenges that this brings. One of the reasons for the increasing aging of the world's population is the increase in life expectancy and, since we live longer, it is of paramount importance to live well and to prevent age-associated diseases. In this way, it is crucial to impro...

journal_title：Current molecular medicine

authors： Magalhaes S,Goodfellow BJ,Nunes A

更新日期：2018-01-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) and related neuropathies are a genetically highly heterogeneous group of neurodegenerative disorders. CMT affects both the sensory and motor nerves, distal Hereditary Motor Neuropathies (dHMN) are phenotypically similar disorders involving only motor nerves, while Hereditary Sensory a...

journal_title：Current molecular medicine

authors： Pareyson D,Saveri P,Piscosquito G

更新日期：2014-01-01 00:00:00

abstract：:Prostate cancer is one of the most difficult cancers to treat especially when it becomes hormone resistant such as castrate resistant prostate cancer (CRPC) and subsequent metastatic CRPC. Apart from the genetic alterations in prostate cancer, epigenetic modifications also play an important role in the development and...

journal_title：Current molecular medicine

authors： Giudice A,Montella M,Boccellino M,Crispo A,D'Arena G,Bimonte S,Facchini G,Ciliberto G,Botti G,Quagliuolo L,Caraglia M,Capunzo M

更新日期：2017-01-01 00:00:00

abstract：:Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...

journal_title：Current molecular medicine

authors： Yamaguchi M,Vikulina T,Arbiser JL,Weitzmann MN

更新日期：2014-01-01 00:00:00

abstract：:Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and DesArg(9) bradykinin. It does so by cleaving a C-terminal PRO-X bond. Recent work also indicates that the human PRCP1 activates plasma prekallikrein (PK) to kallikr...

journal_title：Current molecular medicine

authors： Wang J,Matafonov A,Madkhali H,Mahdi F,Watson D,Schmaier AH,Gailani D,Shariat-Madar Z

更新日期：2014-01-01 00:00:00

abstract：:As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobuli...

journal_title：Current molecular medicine

authors： Allen RL,Trowsdale J

更新日期：2004-02-01 00:00:00

abstract：:Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not be...

journal_title：Current molecular medicine

authors： Oujo B,Perez-Barriocanal F,Bernabeu C,Lopez-Novoa JM

更新日期：2013-09-01 00:00:00

abstract：:The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study...

journal_title：Current molecular medicine

authors： Zhong L,Tang J,Kong QP,Sun C,Zhou WP,Yang M,Yao YG,Zhang YP

更新日期：2014-01-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00