Abstract:
:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; this is also reflected by increased levels of OPN in the circulation. Thus, increased OPN levels the plasma are an effect of tumor growth and progression. Functionally, high OPN levels are determinative of higher incidence of bone metastases in mouse models and are clinically correlated with metastatic bone disease and bone resorption in advanced breast cancer patients. Several research efforts have been made to therapeutically target and inhibit the activities of OPN. In this article we have reviewed OPN in its role as an effector of critical steps in tumor progression and metastasis, with a particular emphasis on its role in facilitating bone metastasis of breast cancer. We have also addressed the role of the host-derived OPN in influencing the malignant behavior of the tumor cells.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Shevde LA,Das S,Clark DW,Samant RSdoi
10.2174/156652410791065381subject
Has Abstractpub_date
2010-02-01 00:00:00pages
71-81issue
1eissn
1566-5240issn
1875-5666pii
CMM#07journal_volume
10pub_type
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journal_title:Current molecular medicine
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journal_title:Current molecular medicine
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journal_title:Current molecular medicine
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更新日期:2016-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2020-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2021-01-10 00:00:00
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journal_title:Current molecular medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190315164120
更新日期:2019-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2012-12-01 00:00:00
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更新日期:2004-02-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
abstract::By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Re...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry. The severity and the outcome of a systemic Salmonella infection depends on the "virulence" of the bacteria, on the infectious dose as well as on the genetic makeup and immunological...
journal_title:Current molecular medicine
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更新日期:2002-06-01 00:00:00
abstract::Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...
journal_title:Current molecular medicine
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更新日期:2001-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2012-11-01 00:00:00
abstract::Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...
journal_title:Current molecular medicine
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更新日期:2013-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00