Abstract:
:The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study using data and samples collected in a large geographic region in China. To test this hypothesis, we first performed a linear regression analysis between the prevalence of T2DM and the allele frequency of 16189C variant in 10 East Asian populations, and further genotyped this variant in two casecontrol cohorts from west Han Chinese (Kunming and Xining). Linear regression analysis showed that no significant correlation was observed (r(2)=0.211, P=0.181), and the genotyping results indicated that the m.16189T>C frequency difference between case and control was not significant in either populations (P=0.38 and 0.89 for Kunming and Xining, respectively). Matrilineal backgrounds constitution (in terms of haplogroups) analysis generated a similar haplogroup distribution in both populations (P>0.1). All results failed to substantiate that m.16189T>C may play an active role in the development of T2DM in East Asian populations.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Zhong L,Tang J,Kong QP,Sun C,Zhou WP,Yang M,Yao YG,Zhang YPdoi
10.2174/1566524014666141202161326subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1273-8issue
10eissn
1566-5240issn
1875-5666pii
CMM-EPUB-63765journal_volume
14pub_type
杂志文章abstract::Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...
journal_title:Current molecular medicine
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2001-03-01 00:00:00
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更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacifi...
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更新日期:2017-01-01 00:00:00
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更新日期:2002-06-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2014-01-01 00:00:00
abstract::Mood disorders and schizophrenia share a number of common properties, including: genetic susceptibility; differences in brain structure and drug based therapy. Some genetic loci may even confer susceptibility for bipolar mood disorder and schizophrenia, and some atypical antipsychotic drugs are used as mood stabilizer...
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更新日期:2003-08-01 00:00:00