Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis.

abstract：:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...

journal_title：Current molecular medicine

authors： Vasieva O

更新日期：2011-03-01 00:00:00

abstract：:Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more ef...

journal_title：Current molecular medicine

authors： Bellati F,Napoletano C,Ruscito I,Visconti V,Antonilli M,Gasparri ML,Zizzari IG,Rahimi H,Palaia I,Rughetti A,Benedetti Panici P,Nuti M

更新日期：2013-05-01 00:00:00

abstract：:The world is aging and we must face the challenges that this brings. One of the reasons for the increasing aging of the world's population is the increase in life expectancy and, since we live longer, it is of paramount importance to live well and to prevent age-associated diseases. In this way, it is crucial to impro...

journal_title：Current molecular medicine

authors： Magalhaes S,Goodfellow BJ,Nunes A

更新日期：2018-01-01 00:00:00

abstract：:Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Respo...

journal_title：Current molecular medicine

authors： Rozpedek W,Pytel D,Mucha B,Leszczynska H,Diehl JA,Majsterek I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Photoreceptor cell death is a key pathology of retinal degeneration diseases. To date, the molecular mechanisms for this pathological process remain largely unclear. Junctional adhesion molecule-c (Jam-c) has been shown to play important roles in different biological events. However, its effect on retinal ne...

journal_title：Current molecular medicine

authors： Li Y,Zhang F,Lu W,Li X

更新日期：2018-03-09 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The study aimed to evaluate the preventive effects of hydroxycitric acid（HCA） for stone formation in the glyoxylate-induced mouse model. MATERIALS AND METHODS:Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood...

journal_title：Current molecular medicine

authors： Liu X,Yuan P,Sun X,Chen Z

更新日期：2020-01-01 00:00:00

abstract：:Nanotechnology has witnessed tremendous advancement over the last several decades. Zinc oxide (ZnO), which can exhibit a wide variety of nanostructures, possesses unique semiconducting, optical, and piezoelectric properties hence has been investigated for a wide variety of applications. The most important features of ...

journal_title：Current molecular medicine

authors： Zhang Y,Nayak TR,Hong H,Cai W

更新日期：2013-12-01 00:00:00

abstract：:After several years of controversy, antibodies (Abs) are now believed to play an important role in the protection against fungal infections. Among them, recent data are strongly supporting the relevance of protective yeast killer toxin-like Abs ("antibiobodies", KT-Abs), which are able to exert a direct microbicidal a...

journal_title：Current molecular medicine

authors： Magliani W,Conti S,Frazzi R,Ravanetti L,Maffei DL,Polonelli L

更新日期：2005-06-01 00:00:00

abstract：:Non-invasive energy metabolism measurements in brain tumors in vivo are now performed widely as molecular imaging by positron emission tomography. This capability has developed from a large number of basic and clinical science investigations that have cross fertilized one another. Apart from precise anatomical localiz...

journal_title：Current molecular medicine

authors： Schaller BJ,Cornelius JF,Sandu N,Buchfelder M

更新日期：2008-12-01 00:00:00

abstract：:T cells, as they develop in the thymus come to express antigen receptors. The specificity of these receptors cannot be predicted and must include many with potential anti-self reactivity. Those that encounter self-antigens, in association with self-MHC (major histocompatibility complex), with high affinity are inactiv...

journal_title：Current molecular medicine

authors： Huang FP,MacPherson GG

更新日期：2001-09-01 00:00:00

abstract：:Inhibition of tumor angiogenesis suppresses tumor growth and metastatic spreading in many experimental models, suggesting that anti-angiogenic drugs may be used to treat human cancer. During the past decade more than eighty molecules that showed anti-angiogenic activity in preclinical studies were tested in clinical c...

journal_title：Current molecular medicine

authors： Rüegg C,Meuwly JY,Driscoll R,Werffeli P,Zaman K,Stupp R

更新日期：2003-12-01 00:00:00

abstract：:Most lysosomal storage diseases (LSD) exhibit neurological symptoms and there has been limited success in their treatment. Innovative treatments employing novel therapy or gene therapy may offer the prospect of improvement. Recent attempts to treat the neurological forms of LSD include neural stem cell therapy, mesenc...

journal_title：Current molecular medicine

authors： Eto Y,Ohashi T

更新日期：2002-02-01 00:00:00

abstract：:Citrate is one of the major substrates for intracellular metabolism. The extracellular level of citrate is stable in blood but varies locally, with slightly increased levels in brain and high levels in prostate. Recent metabolomics research suggests that citrate level is a potential harbinger of different pathophysiol...

journal_title：Current molecular medicine

authors： Mycielska ME,Milenkovic VM,Wetzel CH,Rümmele P,Geissler EK

更新日期：2015-01-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...

journal_title：Current molecular medicine

authors： Shtrichman R,Germanguz I,Itskovitz-Eldor J

更新日期：2013-06-01 00:00:00

abstract：:Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...

journal_title：Current molecular medicine

authors： Be NA,Kim KS,Bishai WR,Jain SK

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To detect mutations of trypsinogen gene (PRSS1) in patients with autoimmune pancreatitis (AIP) and to determine the underlying pathogenesis. METHODS:DNA sequencing was used to detect full-length of PRSS1, cystic fibrosis transmembrane conductance regulator (CFTR), and pancreatic secretory trypsin inhibitor (...

journal_title：Current molecular medicine

authors： Gao F,Li Y,Wang C,Zhuang Z,Liu QC,Chen J,Hong G,Xu Z

更新日期：2014-03-01 00:00:00

abstract：:In 1968 Berger and Hinglais published the first description of IgA nephropathy (IgAN). In the ensuing 30 years, extensive clinical, epidemiologic, and immunologic characterizations of primary (idiopathic) glomerulonephritis with IgA as the predominant or co-dominant immunoglobulin deposited in the mesangia of all glom...

journal_title：Current molecular medicine

authors： Hsu SI

更新日期：2001-05-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and g...

journal_title：Current molecular medicine

authors： Kovacs Z,Guttman A

更新日期：2018-01-01 00:00:00

abstract：:The blood stage of the malaria parasite's life cycle is responsible for all the clinical symptoms of malaria. The development of clinical disease is dependent on the interplay of the infecting parasite with the immune status and genetic background of the host. Following repeated exposure to malaria parasites, individu...

journal_title：Current molecular medicine

authors： Yazdani SS,Mukherjee P,Chauhan VS,Chitnis CE

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation o...

journal_title：Current molecular medicine

authors： Huang L,Tjakra M,Luo D,Wen L,Lei D,Wang J,Yin T,Zhang X,Huang J,Wang Y,Wang G

更新日期：2019-01-01 00:00:00

abstract：:Maintenance of ex vivo hematopoietic stem cells (HSC) pool and its differentiated progeny is regulated by complex network of transcriptional factors, cell cycle proteins, extracellular matrix, and their microenvironment through an orchestrated fashion. Strides have been made to understand the mechanisms regulating in ...

journal_title：Current molecular medicine

authors： Aggarwal R,Lu J,Pompili VJ,Das H

更新日期：2012-01-01 00:00:00

abstract：:Structural multitude of nucleic acids serves basis for its multiple merits and applications. During structural transitions, significant to perform respective cellular functions, these DNA forms can vary from the single stranded to multi-stranded species. Hence, beyond the image of a monotonous DNA double-helix, there ...

journal_title：Current molecular medicine

authors： Kaushik M,Kaushik S,Bansal A,Saxena S,Kukreti S

更新日期：2011-12-01 00:00:00

abstract：:Plaque disruption and subsequent thrombus formation play a critical role in the clinical manifestations of atherothrombosis. Vulnerable lesions are characterized by the existence of core rich in lipid, macrophages and tissue factor (TF). Plaque disruption facilitates the interaction between flowing blood with the inne...

journal_title：Current molecular medicine

authors： Viles-Gonzalez JF,Fuster V,Badimon JJ

更新日期：2006-08-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00

abstract：:Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced stages of malignancy. Hypoxic tumors appear to be poorly differentiated. Increasing evidence suggests that hypoxia has the potential to inhi...

journal_title：Current molecular medicine

authors： Kim Y,Lin Q,Glazer PM,Yun Z

更新日期：2009-05-01 00:00:00

abstract：:Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

journal_title：Current molecular medicine

authors： Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

更新日期：2007-11-01 00:00:00

abstract：:Transcutaneous immunization (TCI) involves the direct application of antigen plus adjuvant to skin, taking advantage of the large numbers of Langerhans cells and other resident skin dendritic cells, that process antigen then migrate to draining lymph nodes where immune responses are initiated. We have used this form o...

journal_title：Current molecular medicine

authors： Hickey DK,Bao S,Ikeda LT,Carey AJ,Beagley KW

更新日期：2005-09-01 00:00:00

abstract：:Transmissible Spongiform Encephalopathies or prion related disorders are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and accumulation of a misfolded form of the cellular prion protein (PrP), denoted PrP(Sc). Although the mechanism of neurodegeneration and the involveme...

journal_title：Current molecular medicine

authors： Castilla J,Hetz C,Soto C

更新日期：2004-06-01 00:00:00

abstract：:Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokin...

journal_title：Current molecular medicine

authors： Kumari B,Yadav UCS

更新日期：2018-01-01 00:00:00