Abstract:
:The blood stage of the malaria parasite's life cycle is responsible for all the clinical symptoms of malaria. The development of clinical disease is dependent on the interplay of the infecting parasite with the immune status and genetic background of the host. Following repeated exposure to malaria parasites, individuals residing in endemic areas develop immunity. Naturally acquired immunity provides protection against clinical disease, especially severe malaria and death from malaria, although sterilizing immunity is never achieved. Given the absence of antigen processing in erythrocytes, immunity to blood stage malaria parasites is primarily conferred by humoral immune responses. Cellular and innate immune responses play a role in controlling parasite growth but may also contribute to malaria pathology. Here, we analyze the natural humoral immune responses acquired by individuals residing in P. falciparum endemic areas and review their role in providing protection against malaria. In addition, we review the dual potential of cellular and innate immune responses to control parasite multiplication and promote pathology.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Yazdani SS,Mukherjee P,Chauhan VS,Chitnis CEdoi
10.2174/156652406776055212keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
187-203issue
2eissn
1566-5240issn
1875-5666journal_volume
6pub_type
杂志文章,评审abstract::Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...
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journal_title:Current molecular medicine
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更新日期:2009-11-01 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:2005-03-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2011-07-01 00:00:00
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更新日期:2009-09-01 00:00:00
abstract::Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...
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更新日期:2013-09-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2006-12-01 00:00:00
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更新日期:2010-10-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2002-09-01 00:00:00
abstract::Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety of mechanisms are involved in PDAC biological behaviors, of which, the mechanisms of immune escape may be a pivotal hallmark. HLA-G is a tolerant molecule implicated in tumor escape and serves as a prognostic biomarker in ...
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更新日期:2015-01-01 00:00:00