Cytokine Expression Profile in Aqueous Humor and Sera of Patients with Acute Anterior Uveitis.

abstract：:Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

journal_title：Current molecular medicine

authors： Takimoto Y,Inui A,Kumano H,Kuboki T

更新日期：2003-06-01 00:00:00

abstract：:Human genetic data on psychiatric disorders repeatedly demonstrate the involvement of various genes that are associated with neural development and neurogenesis. Neurogenesis is a biological process that is critical in brain development and continues throughout life. Neurogenesis is a multi-step process starting from ...

journal_title：Current molecular medicine

authors： Osumi N,Guo N,Matsumata M,Yoshizaki K

更新日期：2015-01-01 00:00:00

abstract：:Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...

journal_title：Current molecular medicine

authors： Singer ST,Ataga KI

更新日期：2008-11-01 00:00:00

abstract：:Traditionally regarded as a genetic disease of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease and a significant cause of sudden cardiac death. While the most common etiologies of this phenotypically diverse disease lie in a handful of genes encoding critica...

journal_title：Current molecular medicine

authors： Landstrom AP,Ackerman MJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

journal_title：Current molecular medicine

authors： Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

更新日期：2020-01-01 00:00:00

abstract：:Skin is a complex tissue composed of two very different compartments -- the continuously renewing epidermis made up mostly by keratinocytes and the underlying matrix-rich dermis with the resting fibroblasts as its major cellular components. Both compartments are tightly interconnected and a paracrine mutual interactio...

journal_title：Current molecular medicine

authors： Boukamp P

更新日期：2005-03-01 00:00:00

abstract：:The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has been implicated in various functions, including apop...

journal_title：Current molecular medicine

authors： Veenman L,Gavish M

更新日期：2012-05-01 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the leading causes of blindness in the working population worldwide. Vascular leakage, angiogenesis and neuronal degeneration are key features of DR. Current effective interventions for DR include treatment of systemic risk factors such as elevated blood glucose, blood pressure and ...

journal_title：Current molecular medicine

authors： Zhang X,Wang N,Schachat AP,Bao S,Gillies MC

更新日期：2014-03-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：:Immune tolerance can be induced by numerous methods. This review article aims to draw lines of similarity and contrast between two unique models of immune tolerance, namely Anterior Chamber Associated Immune Deviation (ACAID) and Nickel-induced oral tolerance. ACAID is an immune tolerance model that leads to the gener...

journal_title：Current molecular medicine

authors： Ashour HM

更新日期：2015-01-01 00:00:00

abstract：:T cells, as they develop in the thymus come to express antigen receptors. The specificity of these receptors cannot be predicted and must include many with potential anti-self reactivity. Those that encounter self-antigens, in association with self-MHC (major histocompatibility complex), with high affinity are inactiv...

journal_title：Current molecular medicine

authors： Huang FP,MacPherson GG

更新日期：2001-09-01 00:00:00

abstract：:Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The is...

journal_title：Current molecular medicine

authors： Bertuzzi F,Marzorati S,Secchi A

更新日期：2006-06-01 00:00:00

abstract：:Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty ...

journal_title：Current molecular medicine

authors： Fang EF,Ng TB

更新日期：2011-07-01 00:00:00

abstract：:Type 2 diabetes carries a 2-6-fold increased risk of cardiovascular disease (CVD) and death. Indeed, the risk of major cardiovascular events in Type 2 diabetic patients without history of coronary heart disease (CHD) is equivalent to that observed in non-diabetic subjects with CHD. However, atherosclerosis may also pr...

journal_title：Current molecular medicine

authors： Ziegler D

更新日期：2005-05-01 00:00:00

abstract：:Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety of mechanisms are involved in PDAC biological behaviors, of which, the mechanisms of immune escape may be a pivotal hallmark. HLA-G is a tolerant molecule implicated in tumor escape and serves as a prognostic biomarker in ...

journal_title：Current molecular medicine

authors： Xu YF,Lu Y,Cheng H,Jiang J,Xu J,Long J,Liu L,Ni Q,Liu C,Yu XJ

更新日期：2015-01-01 00:00:00

abstract：:The cell adhesion molecule integrin αvβ3 is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin αvβ3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) ...

journal_title：Current molecular medicine

authors： Liu Z,Wang F

更新日期：2013-12-01 00:00:00

abstract：:Our current understanding of the mechanisms of information processing and storage in the brain, based on the concept proposed more than fifty years ago by D. Hebb, is that a key role is played by changes in synaptic efficacy induced by coincident pre- and postsynaptic activity. Decades of studies of the properties of ...

journal_title：Current molecular medicine

authors： Muller D,Nikonenko I,Jourdain P,Alberi S

更新日期：2002-11-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...

journal_title：Current molecular medicine

authors： Boyce JA

更新日期：2008-08-01 00:00:00

abstract：:Enteroviruses are common human pathogens involved in a wide spectrum of clinical outcomes ranging from mild or non-symptomatic illness to severe diseases with neurological and/or cardiac manifestation. Despite being responsible for significant morbidity and mortality especially in immunocompromised patients and infant...

journal_title：Current molecular medicine

authors： Schönhofer-Merl S,Wessely R

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacifi...

journal_title：Current molecular medicine

authors： Bao X,Hou M,Peng R,Luo F,Wu M

更新日期：2017-01-01 00:00:00

abstract：:Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

journal_title：Current molecular medicine

authors： Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

更新日期：2007-11-01 00:00:00

abstract：:Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism ...

journal_title：Current molecular medicine

authors： Aso Y

更新日期：2008-09-01 00:00:00

abstract：:p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is ma...

journal_title：Current molecular medicine

authors： Zhang J,Chen X

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:15 pati...

journal_title：Current molecular medicine

authors： Zhao B,Zhang S,Chen W,Zhang R,Jiang R,Zhang R,Chen L

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology. OBJECTIVES:To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers o...

journal_title：Current molecular medicine

authors： Taha IM,Allah AMA,El Tarhouny S

更新日期：2019-01-01 00:00:00

abstract：:The view that mitochondrial electron transport is the only site of aerobic respiration and the primary bioenergetic pathway in mammalian cells is well established in the literature. Although this paradigm is widely accepted for most tissues, the situation is less clear for proliferating cells. Increasing evidence indi...

journal_title：Current molecular medicine

authors： Herst PM,Berridge MV

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：:Mood disorders and schizophrenia share a number of common properties, including: genetic susceptibility; differences in brain structure and drug based therapy. Some genetic loci may even confer susceptibility for bipolar mood disorder and schizophrenia, and some atypical antipsychotic drugs are used as mood stabilizer...

journal_title：Current molecular medicine

authors： Harwood AJ

更新日期：2003-08-01 00:00:00

abstract：:The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulat...

journal_title：Current molecular medicine

authors： Zhang L,Li DW

更新日期：2016-01-01 00:00:00