High Expression of Human Leukocyte Antigen-G is Associated with a Poor Prognosis in Patients with PDAC.

abstract：:PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol...

journal_title：Current molecular medicine

authors： De Melo J,He L,Tang D

更新日期：2014-01-01 00:00:00

abstract：:Mucolipidosis Type IV (MLIV) is a lysosomal storage disorder that is characterized by severe neurologic and ophthalmologic abnormalities. It is a progressive disease that usually presents during the first year of life with mental retardation, corneal opacities, and delayed motor milestones. First described in 1974, ML...

journal_title：Current molecular medicine

authors： Slaugenhaupt SA

更新日期：2002-08-01 00:00:00

abstract：:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...

journal_title：Current molecular medicine

authors： Vasieva O

更新日期：2011-03-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:WHIM syndrome is a dominantly inherited primary immunodeficiency disorder representing the first identified example of human disease caused by mutations in the gene encoding for the chemokine receptor CXCR4. Pathogenesis is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL1...

journal_title：Current molecular medicine

authors： Dotta L,Tassone L,Badolato R

更新日期：2011-06-01 00:00:00

abstract：:Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more ef...

journal_title：Current molecular medicine

authors： Bellati F,Napoletano C,Ruscito I,Visconti V,Antonilli M,Gasparri ML,Zizzari IG,Rahimi H,Palaia I,Rughetti A,Benedetti Panici P,Nuti M

更新日期：2013-05-01 00:00:00

abstract：:Although it has been known for long time that atherosclerosis is associated with lipid deposition, only recently it has been accepted that the plasmatic concentration of cholesterol, especially LDL cholesterol, is a risk factor for atherosclerosis. However, chemically modified LDL, but not native LDL, is able to induc...

journal_title：Current molecular medicine

authors： Albertini R,Moratti R,De Luca G

更新日期：2002-09-01 00:00:00

abstract：:Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty ...

journal_title：Current molecular medicine

authors： Fang EF,Ng TB

更新日期：2011-07-01 00:00:00

abstract：:Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

journal_title：Current molecular medicine

authors： Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

更新日期：2012-09-01 00:00:00

abstract：:Chondroitin sulfate (CS)-glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides attached to CS proteoglycans that make up a major component of biological matrices throughout both central and peripheral tissues. The position of their attached sulfate groups to the CS disaccharide is predicted to influ...

journal_title：Current molecular medicine

authors： Alonge K,Harkewicz R,Guttman M

更新日期：2020-09-15 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen, which is the cause of a tick-borne illness occurring in many areas of Africa, Asia, and Europe. CCHF is characterized by a sudden onset of high fever, chills, and severe headache. Other symptoms can include gastrointestinal disorders, such a...

journal_title：Current molecular medicine

authors： Flick R,Whitehouse CA

更新日期：2005-12-01 00:00:00

abstract：:The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various grou...

journal_title：Current molecular medicine

authors： Abdel-Rahman WM,Faris ME,Peltomaki P

更新日期：2017-01-01 00:00:00

abstract：:Spider venom is a large pharmacological repertoire containing many biologically active peptides, which may have a potent therapeutic implication. Here we investigated a peptide toxin, named lycosin-I, isolated from the venom of the spider Lycosa singoriensis. In contrast to most spider peptide toxins adopting inhibito...

journal_title：Current molecular medicine

authors： Liu Z,Deng M,Xiang J,Ma H,Hu W,Zhao Y,Li DW,Liang S

更新日期：2012-12-01 00:00:00

abstract：:Our current understanding of the mechanisms of information processing and storage in the brain, based on the concept proposed more than fifty years ago by D. Hebb, is that a key role is played by changes in synaptic efficacy induced by coincident pre- and postsynaptic activity. Decades of studies of the properties of ...

journal_title：Current molecular medicine

authors： Muller D,Nikonenko I,Jourdain P,Alberi S

更新日期：2002-11-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：:Abstract: The study of genetic alterations in tumors and their precursor lesions is often hampered by the presence of a heterogeneous background of non-neoplastic elements such as stromal cells, inflammatory cells, and angiogenic elements. Microdissection involves the extraction of specific populations of cells under ...

journal_title：Current molecular medicine

authors： Maitra A,Wistuba II,Gazdar AF

更新日期：2001-03-01 00:00:00

abstract：:Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

journal_title：Current molecular medicine

authors： Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

更新日期：2011-08-01 00:00:00

abstract：:Necrotic cell death has long been considered an accidental and uncontrolled mode of cell death. But recently it has become clear that necrosis is a molecularly regulated event that is associated with pathologies such as ischemia-reperfusion (IR) injury, neurodegeneration and pathogen infection. The serine/threonine ki...

journal_title：Current molecular medicine

authors： Vanlangenakker N,Vanden Berghe T,Krysko DV,Festjens N,Vandenabeele P

更新日期：2008-05-01 00:00:00

abstract：:Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited polycythaemia. VHL disease is a multisystem familial cancer syndrome and is the commonest cause of familial renal cell carcinoma (RCC). VHL disease ...

journal_title：Current molecular medicine

authors： Maher ER

更新日期：2004-12-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a metabolic disorder characterised by the inability of β-cells to secrete enough insulin to maintain glucose homeostasis. Pancreatic β-cells secrete insulin in a biphasic manner, first and second phase insulin secretion, and loss of first phase insulin secretion is an independent predictor of ...

journal_title：Current molecular medicine

authors： Cheng K,Andrikopoulos S,Gunton JE

更新日期：2013-01-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biologic...

journal_title：Current molecular medicine

authors： Shtrichman R,Germanguz I,Itskovitz-Eldor J

更新日期：2013-06-01 00:00:00

abstract：:Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elici...

journal_title：Current molecular medicine

authors： Multhoff G,Pockley AG,Streffer C,Gaipl US

更新日期：2012-11-01 00:00:00

abstract：:Transmissible Spongiform Encephalopathies or prion related disorders are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and accumulation of a misfolded form of the cellular prion protein (PrP), denoted PrP(Sc). Although the mechanism of neurodegeneration and the involveme...

journal_title：Current molecular medicine

authors： Castilla J,Hetz C,Soto C

更新日期：2004-06-01 00:00:00

abstract：:Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The is...

journal_title：Current molecular medicine

authors： Bertuzzi F,Marzorati S,Secchi A

更新日期：2006-06-01 00:00:00

abstract：:The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulat...

journal_title：Current molecular medicine

authors： Zhang L,Li DW

更新日期：2016-01-01 00:00:00

abstract：:Peroxisomal proliferator activated receptor gamma (PPARgamma) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of target genes. The regulatory role of this receptor on lipid metabolism and insulin sensitization is well established. Recently, the overexpression of this re...

journal_title：Current molecular medicine

authors： Krishnan A,Nair SA,Pillai MR

更新日期：2007-09-01 00:00:00

abstract：:Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and DesArg(9) bradykinin. It does so by cleaving a C-terminal PRO-X bond. Recent work also indicates that the human PRCP1 activates plasma prekallikrein (PK) to kallikr...

journal_title：Current molecular medicine

authors： Wang J,Matafonov A,Madkhali H,Mahdi F,Watson D,Schmaier AH,Gailani D,Shariat-Madar Z

更新日期：2014-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the leading causes of blindness in the working population worldwide. Vascular leakage, angiogenesis and neuronal degeneration are key features of DR. Current effective interventions for DR include treatment of systemic risk factors such as elevated blood glucose, blood pressure and ...

journal_title：Current molecular medicine

authors： Zhang X,Wang N,Schachat AP,Bao S,Gillies MC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear. METHODS AND RESULTS:This study investigates the effects of LA on...

journal_title：Current molecular medicine

authors： Yang Y,Huang J,Li J,Yang H,Yin Y

更新日期：2020-01-01 00:00:00

abstract：:The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. Increase in sedentary lifestyle and consumption of more energy-dense diet increased the incidence of obesity which is a significant ri...

journal_title：Current molecular medicine

authors： Yaribeygi H,Maleki M,Sathyapalan T,Jamialahmadi T,Sahebkar A

更新日期：2020-08-12 00:00:00