First phase insulin secretion and type 2 diabetes.

abstract：:Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more ef...

journal_title：Current molecular medicine

authors： Bellati F,Napoletano C,Ruscito I,Visconti V,Antonilli M,Gasparri ML,Zizzari IG,Rahimi H,Palaia I,Rughetti A,Benedetti Panici P,Nuti M

更新日期：2013-05-01 00:00:00

abstract：:The generation of functional neural progenitor cells (NPCs) independent of donor brain tissue and embryonic tissues is of great therapeutic interest with regard to regenerative medicine and the possible treatment of neurodegenerative disorders. Traditionally, NPCs are derived through the differentiation of embryonic s...

journal_title：Current molecular medicine

authors： Tian C,Ambroz RJ,Sun L,Wang Y,Ma K,Chen Q,Zhu B,Zheng JC

更新日期：2012-02-01 00:00:00

abstract：:Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokin...

journal_title：Current molecular medicine

authors： Kumari B,Yadav UCS

更新日期：2018-01-01 00:00:00

abstract：:Nanotechnology has witnessed tremendous advancement over the last several decades. Zinc oxide (ZnO), which can exhibit a wide variety of nanostructures, possesses unique semiconducting, optical, and piezoelectric properties hence has been investigated for a wide variety of applications. The most important features of ...

journal_title：Current molecular medicine

authors： Zhang Y,Nayak TR,Hong H,Cai W

更新日期：2013-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific destruction of insulin-producing pancreatic beta-cells, culminating in a state of hypoinsulinemia and hyperglycemia. Pathogenesis of T1D comprises complex series of events from the initial sensitization of antigen-presenting cell...

journal_title：Current molecular medicine

authors： Kim HS,Lee MS

更新日期：2009-02-01 00:00:00

abstract：:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...

journal_title：Current molecular medicine

authors： Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJ

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The phenotypic severity of β-thalassemia is highly modulated by three genetic modifiers: β-globin (HBB) mutations, co-inheritance of α-thalassemia and polymorphisms in the genes associated with fetal haemoglobin (HbF) production. This study was aimed to evaluate the effect of HbF related polymorphisms mainly...

journal_title：Current molecular medicine

authors： Razak SAA,Murad NAA,Masra F,Chong DLS,Abdullah N,Jalil N,Alauddin H,Sabudin RZAR,Ithnin A,Khai LC,Aziz NA,Muda Z,Ibrahim H,Latiff ZA

更新日期：2018-01-01 00:00:00

abstract：:Traditionally regarded as a genetic disease of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease and a significant cause of sudden cardiac death. While the most common etiologies of this phenotypically diverse disease lie in a handful of genes encoding critica...

journal_title：Current molecular medicine

authors： Landstrom AP,Ackerman MJ

更新日期：2012-06-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct program...

journal_title：Current molecular medicine

authors： Gu J,Cromer B,Sumer H

更新日期：2020-04-21 00:00:00

abstract：PURPOSE:Accumulated evidence have well established that protein sumoylation plays multiple roles in various cellular processes. In the vertebrate eye, we and others have demonstrated that sumoylation displays indispensable roles in regulating eye development. Various ocular cell lines including human embryonic cell lin...

journal_title：Current molecular medicine

authors： Liu Y,Zhang L,Tang X,Liu F,Fu JL,Gong XD,Wang L,Nie Q,Xiang JW,Xiao Y,Liu Y,Li DW

更新日期：2018-01-01 00:00:00

abstract：:Many autoimmune diseases have genetic associations with the Major Histocompatibility Complex (MHC) class II loci. Susceptibility to Type 1 diabetes mellitus (TIDM) is particularly associated with Human Leucocyte Antigen (HLA) DR3, 4 and associated DQ2, 8 alleles and this is well documented in genetic association studi...

journal_title：Current molecular medicine

authors： Wong FS,Wen L

更新日期：2003-02-01 00:00:00

abstract：:Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanis...

journal_title：Current molecular medicine

authors： Mancardi D,Ridnour LA,Thomas DD,Katori T,Tocchetti CG,Espey MG,Miranda KM,Paolocci N,Wink DA

更新日期：2004-11-01 00:00:00

abstract：:In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...

journal_title：Current molecular medicine

authors： Pan J,Liu H,Zhou J,Liu Z,Yang Y,Peng Y,You H,Yang D,Xie P

更新日期：2014-01-01 00:00:00

abstract：:Primary malignancies of the liver and the gastrointestinal tract constitute one of the main health problems worldwide. Together, these types of tumour are the first cause of death due to cancer, followed by lung and breast cancer respectively. One important limitation in the treatment of these tumours is that, with a ...

journal_title：Current molecular medicine

authors： Marin JJ,Romero MR,Martinez-Becerra P,Herraez E,Briz O

更新日期：2009-12-01 00:00:00

abstract：:Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced ap...

journal_title：Current molecular medicine

authors： Gupta S

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

journal_title：Current molecular medicine

authors： Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

更新日期：2019-01-01 00:00:00

abstract：:Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Respo...

journal_title：Current molecular medicine

authors： Rozpedek W,Pytel D,Mucha B,Leszczynska H,Diehl JA,Majsterek I

更新日期：2016-01-01 00:00:00

abstract：:WHIM syndrome is a dominantly inherited primary immunodeficiency disorder representing the first identified example of human disease caused by mutations in the gene encoding for the chemokine receptor CXCR4. Pathogenesis is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL1...

journal_title：Current molecular medicine

authors： Dotta L,Tassone L,Badolato R

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In this study, the antioxidant property of new synthesized azomethins has been investigated as theoretical and experimental. METHODS AND RESULTS:Density functional theory (DFT) was employed to investigate the Bond Dissociation Enthalpy (BDE), Mulliken Charges, NBO analysis, Ionization Potential (IP), Electr...

journal_title：Current molecular medicine

authors： Shahab S,Sheikhi M,Filippovich L,Dikusar E,Pazniak A,Rouhani M,Kumar R

更新日期：2019-01-01 00:00:00

abstract：:HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1-ind...

journal_title：Current molecular medicine

authors： Rauvala H,Rouhiainen A

更新日期：2007-12-01 00:00:00

abstract：:Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...

journal_title：Current molecular medicine

authors： Pezzini A,Del Zotto E,Giossi A,Volonghi I,Grassi M,Padovani A

更新日期：2009-03-01 00:00:00

abstract：:The identification of a relevant effector of Ran GTPase (Ran) signaling and its pathways could provide a novel approach to cancer therapeutics. With recent research highlighting the significant relationship between Ran expression and the occurrence and progression of cancer, the development of a small molecule compoun...

journal_title：Current molecular medicine

authors： Doherty KJ,McKay C,Chan KK,El-Tanani MK

更新日期：2011-11-01 00:00:00

abstract：:A framework was developed to provide an integrated view of mycobacterial growth and its regulation. The topics reviewed include the properties of cell cultures and their relation to properties of individual cells, cell sizes and macromolecular compositions, uptake of nutrients through the cell envelope, protein biosyn...

journal_title：Current molecular medicine

authors： Cox RA,Cook GM

更新日期：2007-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...

journal_title：Current molecular medicine

authors： Estep JM,Birerdinc A,Younossi Z

更新日期：2010-03-01 00:00:00

abstract：:The central role of glutamate receptors in mediating excitotoxic neuronal death in stroke, epilepsy and trauma has been well established. Glutamate is the major excitatory amino acid transmitter within the CNS and it's signaling is mediated by a number of postsynaptic ionotropic and metabotropic receptors. Although ca...

journal_title：Current molecular medicine

authors： Aarts MM,Tymianski M

更新日期：2004-03-01 00:00:00

abstract：:Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential relationship between the expression levels of GHRH-R and the placental...

journal_title：Current molecular medicine

authors： Liu AX,Zhang D,Zhu YM,Gao HJ,Jiang JY,Hu XL,Lv PP,Leung PC,Huang HF

更新日期：2016-01-01 00:00:00

abstract：:After several years of controversy, antibodies (Abs) are now believed to play an important role in the protection against fungal infections. Among them, recent data are strongly supporting the relevance of protective yeast killer toxin-like Abs ("antibiobodies", KT-Abs), which are able to exert a direct microbicidal a...

journal_title：Current molecular medicine

authors： Magliani W,Conti S,Frazzi R,Ravanetti L,Maffei DL,Polonelli L

更新日期：2005-06-01 00:00:00

abstract：:The cell adhesion molecule integrin αvβ3 is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin αvβ3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) ...

journal_title：Current molecular medicine

authors： Liu Z,Wang F

更新日期：2013-12-01 00:00:00

abstract：:Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria h...

journal_title：Current molecular medicine

authors： Fathizadeh H,Saffari M,Esmaeili D,Moniri R,Kafil HS

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...

journal_title：Current molecular medicine

authors： Chen F,Yuan W,Mo X,Zhuang J,Wang Y,Chen J,Jiang Z,Zhu X,Zeng Q,Wan Y,Li F,Shi Y,Cao L,Fan X,Luo S,Ye X,Chen Y,Dai G,Gao J,Wang X,Xie H,Zhu P,Li Y,Wu X

更新日期：2017-01-01 00:00:00