Abstract:
:Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty active components. The intent of this review is to provide comprehensive and valuable information for medicinal researchers, drug investigators, clinicians, and even patients with an interest in BG. In conclusion, BG is a cornucopia of health and it deserves in-depth investigations for clinical application in the future.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Fang EF,Ng TBdoi
10.2174/156652411795976583subject
Has Abstractpub_date
2011-07-01 00:00:00pages
417-36issue
5eissn
1566-5240issn
1875-5666pii
CMM # 113journal_volume
11pub_type
杂志文章,评审abstract::Chondroitin sulfate (CS)-glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides attached to CS proteoglycans that make up a major component of biological matrices throughout both central and peripheral tissues. The position of their attached sulfate groups to the CS disaccharide is predicted to influ...
journal_title:Current molecular medicine
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doi:10.2174/1566524020666200915110707
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abstract::Mistletoe is often used as complementary therapy in oncology. The anti-tumor effects of mistletoe (Iscador) are well documented in-vitro in respect to inhibition of cell proliferation, induction of apoptosis, segmental activation of immune competent cells and trapping of chemotherapeutic drugs within cancer cells by m...
journal_title:Current molecular medicine
pub_type: 杂志文章,多中心研究
doi:10.2174/156652410791317057
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abstract::The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study...
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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journal_title:Current molecular medicine
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journal_title:Current molecular medicine
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-09-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2010-10-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2017-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2003-03-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2019-01-01 00:00:00
abstract::Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...
journal_title:Current molecular medicine
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更新日期:2007-02-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
abstract::p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
abstract:PURPOSE:A small molecular compound, aminooxy-acetic acid (AOA), has been shown to modulate experimental autoimmune encephalomyelitis (EAE). The current study was designed to investigate whether AOA has a similar effect on the development of experimental autoimmune uveitis (EAU) and to further explore underlying mechani...
journal_title:Current molecular medicine
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更新日期:2020-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2009-05-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524020666200413112030
更新日期:2020-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/156652410791065318
更新日期:2010-04-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652408783565595
更新日期:2008-02-01 00:00:00
abstract::Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666140724104842
更新日期:2014-01-01 00:00:00
abstract::Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited polycythaemia. VHL disease is a multisystem familial cancer syndrome and is the commonest cause of familial renal cell carcinoma (RCC). VHL disease ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
abstract::Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652408785160989
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND & OBJECTIVE:Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:15 pati...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524018666180207152941
更新日期:2018-03-09 00:00:00