Entosis and Related Forms of Cell Death within Cells.


:By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Recently a unique cell death pathway called "cell-in-cell death" has been defined. Unlike traditional cell death pathways, cell-in-cell death, characterized by cell death within another cell, is triggered by the invasion of one cell into its neighbor and executed by either lysosome-dependent degradation or caspase-dependent apoptosis. With remarkable progresses on cell-in-cell over past few years, multiple mechanisms, including entosis, cannibalism and emperitosis, are found to be responsible for cell-in-cell death. Some key questions, such as specific biochemical markers to distinguish precisely the properties of different cell-in-cell structures and the physiological and pathological relevance, remain to be addressed. In light of this situation and a surge of interests, leading scientists in this field intend to share with readers current research progresses on cell-in-cell structures from different model systems through this special edition on cell-in-cell. The mechanistic advances will be highlighted while the future researches be speculated.


Curr Mol Med


Wang Y,Wang XD




Has Abstract


2015-01-01 00:00:00














  • Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide.

    abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of m...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zhang L,Sun J,Liu Z,Dai Y,Luo Z,Jiang X,Li Z,Li Y,Cao P,Zhou Y,Zeng Z,Tang A,Li X,Li X,Xiang J,Li G

    更新日期:2014-01-01 00:00:00

  • Targeting the process of farynesylation for therapy of hematologic malignancies.

    abstract::In sum, the FTIs are signal transduction inhibitors that display promising clinical activity against a broad spectrum of malignancies. We are just beginning to explore and elucidate the mechanisms by which transformed cells respond to FTIs and the optimal settings in which they do so. The clinical trials that are curr...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Karp JE,Lancet JE

    更新日期:2005-11-01 00:00:00

  • High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells.

    abstract:BACKGROUND:Oxidative stress and chronic hyperglycemia are two major side effects of type 2 diabetes affecting all cell types including mesenchymal stem cells (MSCs). As a cell therapy choice, understanding the behavior of MSCs will provide crucial information for efficient treatment. METHODS:Placental mesenchymal stem...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Roohi A,Nikougoftar M,Montazeri H,Navabi S,Shokri F,Ostad SN,Ghahremani MH

    更新日期:2019-01-01 00:00:00

  • Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles.

    abstract::There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

    更新日期:2012-07-01 00:00:00

  • Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.

    abstract:OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

    更新日期:2014-05-01 00:00:00

  • Extracellular Citrate in Health and Disease.

    abstract::Citrate is one of the major substrates for intracellular metabolism. The extracellular level of citrate is stable in blood but varies locally, with slightly increased levels in brain and high levels in prostate. Recent metabolomics research suggests that citrate level is a potential harbinger of different pathophysiol...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Mycielska ME,Milenkovic VM,Wetzel CH,Rümmele P,Geissler EK

    更新日期:2015-01-01 00:00:00

  • Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases.

    abstract::Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and lysophospholipids. Mammalian PLA2s are divided into two major classes according to their molecular mass and location: intracellular PLA2 a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Touqui L,Alaoui-El-Azher M

    更新日期:2001-12-01 00:00:00

  • Nanotechnology as an adjunct tool for transplanting engineered cells and tissues.

    abstract::Laboratory and clinical studies have provided evidence of feasibility, safety and efficacy of cell transplantation to treat a wide variety of diseases characterized by tissue and cell dysfunction ranging from diabetes to spinal cord injury. However, major hurdles remain and limit pursuing large clinical trials, includ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Borlongan CV,Masuda T,Walker TA,Maki M,Hara K,Yasuhara T,Matsukawa N,Emerich DF

    更新日期:2007-11-01 00:00:00

  • Orexigenic/anorexigenic signals in bulimia nervosa.

    abstract::Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Takimoto Y,Inui A,Kumano H,Kuboki T

    更新日期:2003-06-01 00:00:00

  • Chemokines in cardiovascular remodeling: clinical and therapeutic implications.

    abstract::Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular rem...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Filippatos G,Parissis JT,Adamopoulos S,Kardaras F

    更新日期:2003-03-01 00:00:00

  • p53 peptide prevents LITAF-induced TNF-alpha-mediated mouse lung lesions and endotoxic shock.

    abstract::Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

    更新日期:2011-08-01 00:00:00

  • Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).

    abstract::Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and DesArg(9) bradykinin. It does so by cleaving a C-terminal PRO-X bond. Recent work also indicates that the human PRCP1 activates plasma prekallikrein (PK) to kallikr...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Wang J,Matafonov A,Madkhali H,Mahdi F,Watson D,Schmaier AH,Gailani D,Shariat-Madar Z

    更新日期:2014-01-01 00:00:00

  • Dopaminergic Genes Polymorphisms and Prefrontal Cortex Efficiency Among Obese People - Whether Gender is a Differentiating Factor?

    abstract:BACKGROUND:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Bieliński M,Lesiewska N,Junik R,Kamińska A,Tretyn A,Borkowska A

    更新日期:2019-01-01 00:00:00

  • Pathogenesis of central nervous system tuberculosis.

    abstract::Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Be NA,Kim KS,Bishai WR,Jain SK

    更新日期:2009-03-01 00:00:00

  • SUMOylation Regulation of Retina Development and Functions.

    abstract::The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulat...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Zhang L,Li DW

    更新日期:2016-01-01 00:00:00

  • Telomere maintenance and tumorigenesis: an "ALT"ernative road.

    abstract::The acquisition of cellular immortality is a critical step in human tumorigenesis. While the vast majority of human tumors activate the catalytic component of telomerase (hTERT) to stabilize their telomeres and attain immortality, a significant portion (7-10%) utilize a poorly defined alternative form of telomere main...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Stewart SA

    更新日期:2005-03-01 00:00:00

  • TAGE (toxic AGEs) theory in diabetic complications.

    abstract::Diabetic complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis. Chronic hyperglycemia is initially involved in the pathogenesis of diabetic micro- and macro-vascular complications via various metabolic derangements. High glucose increa...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Sato T,Iwaki M,Shimogaito N,Wu X,Yamagishi S,Takeuchi M

    更新日期:2006-05-01 00:00:00

  • Past, present and future strategies of immunotherapy in gynecological malignancies.

    abstract::Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more ef...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Bellati F,Napoletano C,Ruscito I,Visconti V,Antonilli M,Gasparri ML,Zizzari IG,Rahimi H,Palaia I,Rughetti A,Benedetti Panici P,Nuti M

    更新日期:2013-05-01 00:00:00

  • Cytokine Expression Profile in Aqueous Humor and Sera of Patients with Acute Anterior Uveitis.

    abstract:PURPOSE:To evaluate cytokine expression profile in aqueous humor and sera in patients with HLAB27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS:Twenty patients with AAU and 17 controls were recruited from August 2012 to March 2013. Study subjects with uveitis were divided into two groups: 9 patie...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Chen W,Zhao B,Jiang R,Zhang R,Wang Y,Wu H,Gordon L,Chen L

    更新日期:2015-01-01 00:00:00

  • Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model.

    abstract:BACKGROUND:Seven isoforms of histone deacetylase Class III have been reported - Sirtuin (SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligationand- puncture (CLP)-induced septic shock. Our present study was aimed at determining whether selecti...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zhao T,Alam HB,Liu B,Bronson RT,Nikolian VC,Wu E,Chong W,Li Y

    更新日期:2015-01-01 00:00:00

  • Role of innate immunity in triggering and tuning of autoimmune diabetes.

    abstract::Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific destruction of insulin-producing pancreatic beta-cells, culminating in a state of hypoinsulinemia and hyperglycemia. Pathogenesis of T1D comprises complex series of events from the initial sensitization of antigen-presenting cell...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Kim HS,Lee MS

    更新日期:2009-02-01 00:00:00

  • Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma.

    abstract::Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Schwarzer R,Jundt F

    更新日期:2011-04-01 00:00:00

  • Osteopontin: an effector and an effect of tumor metastasis.

    abstract::Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Shevde LA,Das S,Clark DW,Samant RS

    更新日期:2010-02-01 00:00:00

  • RAN GTPase as a target for cancer therapy: Ran binding proteins.

    abstract::The identification of a relevant effector of Ran GTPase (Ran) signaling and its pathways could provide a novel approach to cancer therapeutics. With recent research highlighting the significant relationship between Ran expression and the occurrence and progression of cancer, the development of a small molecule compoun...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Doherty KJ,McKay C,Chan KK,El-Tanani MK

    更新日期:2011-11-01 00:00:00

  • Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation.

    abstract:OBJECTIVE:The study aimed to evaluate the preventive effects of hydroxycitric acid(HCA) for stone formation in the glyoxylate-induced mouse model. MATERIALS AND METHODS:Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Liu X,Yuan P,Sun X,Chen Z

    更新日期:2020-01-01 00:00:00

  • PRAME/EZH2-mediated regulation of TRAIL: a new target for cancer therapy.

    abstract::The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a cancer cell-specific pro-apoptotic activity. This property made the TRAIL associated pathway one of the most promising strategies aimed at inducing tumor-selective death. In fact, several approaches have been considered to explore this pathwa...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: De Carvalho DD,Mello BP,Pereira WO,Amarante-Mendes GP

    更新日期:2013-02-01 00:00:00

  • Reappraising the relationship between mitochondrial DNA variant m.16189T>C and type 2 diabetes mellitus in East Asian populations.

    abstract::The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zhong L,Tang J,Kong QP,Sun C,Zhou WP,Yang M,Yao YG,Zhang YP

    更新日期:2014-01-01 00:00:00

  • Specific Roles of NMDA Receptor Subunits in Mental Disorders.

    abstract::N-methyl-D-aspartate (NMDA) receptor plays important roles in learning and memory. NMDA receptors are a tetramer that consists of two glycine-binding subunits GluN1, two glutamate-binding subunits (i.e., GluN2A, GluN2B, GluN2C, and GluN2D), a combination of a GluN2 subunit and glycine-binding GluN3 subunit (i.e., GluN...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Yamamoto H,Hagino Y,Kasai S,Ikeda K

    更新日期:2015-01-01 00:00:00

  • Epigenetic Changes Induced by Green Tea Catechins a re Associated with Prostate Cancer.

    abstract::Prostate cancer is one of the most difficult cancers to treat especially when it becomes hormone resistant such as castrate resistant prostate cancer (CRPC) and subsequent metastatic CRPC. Apart from the genetic alterations in prostate cancer, epigenetic modifications also play an important role in the development and...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Giudice A,Montella M,Boccellino M,Crispo A,D'Arena G,Bimonte S,Facchini G,Ciliberto G,Botti G,Quagliuolo L,Caraglia M,Capunzo M

    更新日期:2017-01-01 00:00:00

  • Molecular steps of tumor necrosis factor receptor-mediated apoptosis.

    abstract::Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced ap...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Gupta S

    更新日期:2001-07-01 00:00:00