Entosis and Related Forms of Cell Death within Cells.


:By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Recently a unique cell death pathway called "cell-in-cell death" has been defined. Unlike traditional cell death pathways, cell-in-cell death, characterized by cell death within another cell, is triggered by the invasion of one cell into its neighbor and executed by either lysosome-dependent degradation or caspase-dependent apoptosis. With remarkable progresses on cell-in-cell over past few years, multiple mechanisms, including entosis, cannibalism and emperitosis, are found to be responsible for cell-in-cell death. Some key questions, such as specific biochemical markers to distinguish precisely the properties of different cell-in-cell structures and the physiological and pathological relevance, remain to be addressed. In light of this situation and a surge of interests, leading scientists in this field intend to share with readers current research progresses on cell-in-cell structures from different model systems through this special edition on cell-in-cell. The mechanistic advances will be highlighted while the future researches be speculated.


Curr Mol Med


Wang Y,Wang XD




Has Abstract


2015-01-01 00:00:00














  • p53 peptide prevents LITAF-induced TNF-alpha-mediated mouse lung lesions and endotoxic shock.

    abstract::Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

    更新日期:2011-08-01 00:00:00

  • Osteopontin: an effector and an effect of tumor metastasis.

    abstract::Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Shevde LA,Das S,Clark DW,Samant RS

    更新日期:2010-02-01 00:00:00

  • Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).

    abstract::Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and DesArg(9) bradykinin. It does so by cleaving a C-terminal PRO-X bond. Recent work also indicates that the human PRCP1 activates plasma prekallikrein (PK) to kallikr...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Wang J,Matafonov A,Madkhali H,Mahdi F,Watson D,Schmaier AH,Gailani D,Shariat-Madar Z

    更新日期:2014-01-01 00:00:00

  • Molecular steps of tumor necrosis factor receptor-mediated apoptosis.

    abstract::Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced ap...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Gupta S

    更新日期:2001-07-01 00:00:00

  • Association of Genetic Variants with Colorectal Cancer in the Extended MENA Region: A Systematic Review.

    abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

    更新日期:2020-01-01 00:00:00

  • Protective antifungal yeast killer toxin-like antibodies.

    abstract::After several years of controversy, antibodies (Abs) are now believed to play an important role in the protection against fungal infections. Among them, recent data are strongly supporting the relevance of protective yeast killer toxin-like Abs ("antibiobodies", KT-Abs), which are able to exert a direct microbicidal a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Magliani W,Conti S,Frazzi R,Ravanetti L,Maffei DL,Polonelli L

    更新日期:2005-06-01 00:00:00

  • Molecular imaging of brain tumors personal experience and review of the literature.

    abstract::Non-invasive energy metabolism measurements in brain tumors in vivo are now performed widely as molecular imaging by positron emission tomography. This capability has developed from a large number of basic and clinical science investigations that have cross fertilized one another. Apart from precise anatomical localiz...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Schaller BJ,Cornelius JF,Sandu N,Buchfelder M

    更新日期:2008-12-01 00:00:00

  • VEGFR1 Signaling Regulates IL-4-Mediated Arginase 1 Expression in Macrophages.

    abstract:BACKGROUND:Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper imm...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zou Y,Chen Q,Ye Z,Li X,Ju R

    更新日期:2017-12-07 00:00:00

  • Specific Roles of NMDA Receptor Subunits in Mental Disorders.

    abstract::N-methyl-D-aspartate (NMDA) receptor plays important roles in learning and memory. NMDA receptors are a tetramer that consists of two glycine-binding subunits GluN1, two glutamate-binding subunits (i.e., GluN2A, GluN2B, GluN2C, and GluN2D), a combination of a GluN2 subunit and glycine-binding GluN3 subunit (i.e., GluN...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Yamamoto H,Hagino Y,Kasai S,Ikeda K

    更新日期:2015-01-01 00:00:00

  • Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line.

    abstract::Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential relationship between the expression levels of GHRH-R and the placental...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Liu AX,Zhang D,Zhu YM,Gao HJ,Jiang JY,Hu XL,Lv PP,Leung PC,Huang HF

    更新日期:2016-01-01 00:00:00

  • Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.

    abstract:OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

    更新日期:2014-05-01 00:00:00

  • Crimean-Congo hemorrhagic fever virus.

    abstract::Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen, which is the cause of a tick-borne illness occurring in many areas of Africa, Asia, and Europe. CCHF is characterized by a sudden onset of high fever, chills, and severe headache. Other symptoms can include gastrointestinal disorders, such a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Flick R,Whitehouse CA

    更新日期:2005-12-01 00:00:00

  • Biology of PPAR gamma in cancer: a critical review on existing lacunae.

    abstract::Peroxisomal proliferator activated receptor gamma (PPARgamma) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of target genes. The regulatory role of this receptor on lipid metabolism and insulin sensitization is well established. Recently, the overexpression of this re...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Krishnan A,Nair SA,Pillai MR

    更新日期:2007-09-01 00:00:00

  • Reprograming Carcinoma Associated Fibroblasts by microRNAs.

    abstract::Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts during development of several cancer types, and therefore emerge as an attractive therapeutic target for cancer therapy. Drugs such as PT-100 and sibrotuzumab that block the functions of CAFs have already been in clinical trials. However, these drugs ex...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Xu Y,Zhou X,Mei M,Ren Y

    更新日期:2017-01-01 00:00:00

  • Molecular mechanisms of resistance to antiviral therapy in patients with chronic hepatitis B.

    abstract::Similar to the human immunodeficiency virus (HIV), the hepatitis B virus (HBV) replicates via reverse transcription, in this case, within infected hepatocytes. Substantial advances have been achieved in the past ten years in developing and utilizing nucleoside/nucleotide analog drugs to inhibit HBV replication. Most a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Yuan HJ,Lee WM

    更新日期:2007-03-01 00:00:00

  • Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development.

    abstract:BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Chen F,Yuan W,Mo X,Zhuang J,Wang Y,Chen J,Jiang Z,Zhu X,Zeng Q,Wan Y,Li F,Shi Y,Cao L,Fan X,Luo S,Ye X,Chen Y,Dai G,Gao J,Wang X,Xie H,Zhu P,Li Y,Wu X

    更新日期:2017-01-01 00:00:00

  • Molecular mechanisms of tumor invasion and metastasis: an integrated view.

    abstract::As tumors progress to increased malignancy, cells within them develop the ability to invade into surrounding normal tissues and through tissue boundaries to form new growths (metastases) at sites distinct from the primary tumor. The molecular mechanisms involved in this process are incompletely understood but those as...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Cairns RA,Khokha R,Hill RP

    更新日期:2003-11-01 00:00:00

  • The migraine-ischemic stroke connection: potential pathogenic mechanisms.

    abstract::Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Pezzini A,Del Zotto E,Giossi A,Volonghi I,Grassi M,Padovani A

    更新日期:2009-03-01 00:00:00

  • Hypoxic tumor microenvironment and cancer cell differentiation.

    abstract::Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced stages of malignancy. Hypoxic tumors appear to be poorly differentiated. Increasing evidence suggests that hypoxia has the potential to inhi...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Kim Y,Lin Q,Glazer PM,Yun Z

    更新日期:2009-05-01 00:00:00

  • Halitosis vaccines targeting FomA, a biofilm-bridging protein of fusobacteria nucleatum.

    abstract::Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Liu PF,Huang IF,Shu CW,Huang CM

    更新日期:2013-09-01 00:00:00

  • Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug.

    abstract:BACKGROUND:Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug. METHODS:In addition, removal of emerging drug contaminants from wastewaters is a necessity that sho...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Fu M,Tayebee R,Saberi S,Nourbakhsh N,Esmaeili E,Maleki B,Vatanpour HR

    更新日期:2021-01-10 00:00:00

  • Mouse models to decipher the PI3K signaling network in human cancer.

    abstract::Deregulation of the PI3K pathway is common in human cancer. The basic players in this pathway are the kinases PI3K and AKT and the phosphatase PTEN. This review will summarize some of the key animal models that have helped us understand this signaling network and its contribution to tumorigenesis. Recently, great adva...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Renner O,Carnero A

    更新日期:2009-06-01 00:00:00

  • New Horizons in the Etiopathogenesis and Non-Invasive Diagnosis of Endometriosis.

    abstract::Endometriosis is one of the most common gynecological inflammatory diseases, occurring in adolescents and women in the reproductive age group and leading to infertility. The precise etiopathogenesis of endometriosis is unknown, but several theories concerning the phenomena involved in its development have been propose...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Zubrzycka A,Zubrzycki M,Janecka A,Zubrzycka M

    更新日期:2015-01-01 00:00:00

  • Growth regulation in the mycobacterial cell.

    abstract::A framework was developed to provide an integrated view of mycobacterial growth and its regulation. The topics reviewed include the properties of cell cultures and their relation to properties of individual cells, cell sizes and macromolecular compositions, uptake of nutrients through the cell envelope, protein biosyn...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Cox RA,Cook GM

    更新日期:2007-05-01 00:00:00

  • The Effects of Lauric Acid on IPEC-J2 Cell Differentiation, Proliferation, and Death.

    abstract:BACKGROUND:Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear. METHODS AND RESULTS:This study investigates the effects of LA on...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Yang Y,Huang J,Li J,Yang H,Yin Y

    更新日期:2020-01-01 00:00:00

  • Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules.

    abstract::Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

    更新日期:2012-09-01 00:00:00

  • Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases.

    abstract::Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and lysophospholipids. Mammalian PLA2s are divided into two major classes according to their molecular mass and location: intracellular PLA2 a...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Touqui L,Alaoui-El-Azher M

    更新日期:2001-12-01 00:00:00

  • Membrane Fusion Mediated Targeted Cytosolic Drug Delivery Through scFv Engineered Sendai Viral Envelopes.

    abstract::Antibody targeted cytoplasmic delivery of drugs is difficult to achieve as antigen-antibody interaction results in the payload being directed to the endosomal compartment. However, Sendai viral envelopes can bring about cytoplasmic delivery due to F-protein mediated membrane fusion. In this study we have generated and...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Kumar M,Mani P,Pratheesh P,Chandra S,Jeyakkodi M,Chattopadhyay P,Sarkar DP,Sinha S

    更新日期:2015-01-01 00:00:00

  • Hypercoagulability in sickle cell disease and beta-thalassemia.

    abstract::Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...

    journal_title:Current molecular medicine

    pub_type: 杂志文章,评审


    authors: Singer ST,Ataga KI

    更新日期:2008-11-01 00:00:00

  • Suppression of NF-κB activation by gentian violet promotes osteoblastogenesis and suppresses osteoclastogenesis.

    abstract::Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...

    journal_title:Current molecular medicine

    pub_type: 杂志文章


    authors: Yamaguchi M,Vikulina T,Arbiser JL,Weitzmann MN

    更新日期:2014-01-01 00:00:00