Abstract:
:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carcinoma) and these patients are believed to develop gastric carcinomas with a molecular genetic profile differing from that of sporadic carcinomas occurring at a later age. In young patients, the role of genetics is presumably greater than in older patients, with less of an impact from environmental carcinogens. As a result, hereditary gastric cancers and early onset gastric cancers can provide vital information about molecular genetic pathways in sporadic cancers and may aid in the unraveling of gastric carcinogenesis. This review focuses on the molecular genetics of gastric cancer and also focuses on early onset gastric cancers as well as familial gastric cancers such as hereditary diffuse gastric cancer. An overview of the various pathways of importance in gastric cancer, as discovered through in-vitro, primary cancer and mouse model studies, is presented and the clinical importance of CDH1 mutations is discussed.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJdoi
10.2174/156652407779940503subject
Has Abstractpub_date
2007-02-01 00:00:00pages
15-28issue
1eissn
1566-5240issn
1875-5666journal_volume
7pub_type
杂志文章,评审abstract::Traditionally regarded as a genetic disease of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease and a significant cause of sudden cardiac death. While the most common etiologies of this phenotypically diverse disease lie in a handful of genes encoding critica...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/156652412800620020
更新日期:2012-06-01 00:00:00
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journal_title:Current molecular medicine
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doi:10.2174/1566524018666171205113959
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更新日期:2004-06-01 00:00:00
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更新日期:2009-03-01 00:00:00
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更新日期:2020-01-01 00:00:00
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更新日期:2008-12-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug. METHODS:In addition, removal of emerging drug contaminants from wastewaters is a necessity that sho...
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doi:10.2174/1566524021666210111104428
更新日期:2021-01-10 00:00:00
abstract:PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...
journal_title:Current molecular medicine
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更新日期:2019-01-01 00:00:00
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更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Persistent hyperlactatemia is associated with greater mortality in shock. Liver is the main site of lactate metabolism. METHOD:In the first part, freshly isolated hepatocytes were incubated in 10% fetal bovine serum William's E medium supplemented with 10 mM lactate. Cells were then exposed to 100 μM ursode...
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pub_type: 杂志文章,评审
doi:10.2174/156652411798062421
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.2174/1566524053586653
更新日期:2005-03-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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更新日期:2017-12-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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更新日期:2016-01-01 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) and related neuropathies are a genetically highly heterogeneous group of neurodegenerative disorders. CMT affects both the sensory and motor nerves, distal Hereditary Motor Neuropathies (dHMN) are phenotypically similar disorders involving only motor nerves, while Hereditary Sensory a...
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更新日期:2014-01-01 00:00:00
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journal_title:Current molecular medicine
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更新日期:2002-11-01 00:00:00
abstract::Enteroviruses are common human pathogens involved in a wide spectrum of clinical outcomes ranging from mild or non-symptomatic illness to severe diseases with neurological and/or cardiac manifestation. Despite being responsible for significant morbidity and mortality especially in immunocompromised patients and infant...
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更新日期:2010-08-01 00:00:00
abstract::Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct program...
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更新日期:2020-04-21 00:00:00
abstract::Conformational or misfolding diseases are a large class of devastating human disorders associated with protein misfolding and aggregation. Most conformational diseases are caused by a combination of genetic and environmental factors, suggesting that spontaneous events can destabilize the protein involved in the pathol...
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pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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更新日期:2006-08-01 00:00:00
abstract::Diabetic retinopathy (DR) is one of the leading causes of blindness in the working population worldwide. Vascular leakage, angiogenesis and neuronal degeneration are key features of DR. Current effective interventions for DR include treatment of systemic risk factors such as elevated blood glucose, blood pressure and ...
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pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00