Abstract:
:The acquisition of cellular immortality is a critical step in human tumorigenesis. While the vast majority of human tumors activate the catalytic component of telomerase (hTERT) to stabilize their telomeres and attain immortality, a significant portion (7-10%) utilize a poorly defined alternative form of telomere maintenance referred to as ALT. Interestingly, telomerase activation is often favored in tumors arising from the epithelial compartment whereas ALT occurs in a more significant portion of tumors that arise from tissues of mesenchymal origin. This observation raises the possibility that cell type specific mechanisms favor the activation of telomerase versus ALT in human tumorigenesis. Because cellular immortality is critical to tumorigenesis it may represent an important anti-neoplastic target. Indeed, several approaches have successfully eliminated telomerase activity in human tumor models and some of these approaches are now moving into clinical trials. While these results are encouraging, it is clear that these approaches will have no impact on cells that utilize the ALT mechanism for telomere maintenance. Furthermore, the existence of ALT raises the possibility that telomerase-positive tumors undergoing anti-telomerase therapies may escape by activating the ALT pathway. For these reasons a detailed understanding of the ALT pathway is critical to the future design of anti-neoplastic therapies.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Stewart SAdoi
10.2174/1566524053586653keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
253-7issue
2eissn
1566-5240issn
1875-5666journal_volume
5pub_type
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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pub_type: 信件
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更新日期:2020-04-27 00:00:00
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-05-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2003-02-01 00:00:00
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更新日期:2017-12-07 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.2174/1566524033479672
更新日期:2003-08-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-10 00:00:00
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journal_title:Current molecular medicine
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-06-01 00:00:00
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更新日期:2005-03-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00