Abstract:
:Many autoimmune diseases have genetic associations with the Major Histocompatibility Complex (MHC) class II loci. Susceptibility to Type 1 diabetes mellitus (TIDM) is particularly associated with Human Leucocyte Antigen (HLA) DR3, 4 and associated DQ2, 8 alleles and this is well documented in genetic association studies. These molecules play an important role in presentation of peptide antigens after intracellular processing to CD4 T lymphocytes. During the last decade, a number of approaches have been used to elucidate the molecular basis for the association of particular alleles with susceptibility to or protection from TIDM. These studies have focused on investigating the structure of the antigen presenting molecules, together with their peptides. Through binding studies, peptide elution, molecular modelling and crystallization of the peptide MHC complex, it has been possible to define the peptide binding regions and examine the stability of binding of peptides from putative autoantigens. This knowledge has also facilitated the development of reagents such as multimeric MHC-peptide complexes that will help to track the low frequency, potentially pathogenic antigen specific cells. Recently, HLA transgenic mice have been generated and used to study T cell epitopes. In addition, although it is clear that the presence of HLA molecules alone does not by itself cause disease, these transgenic mice will develop diabetes when there is an islet "insult", even if the islet "insult" is, itself, not sufficient to precipitate disease in the absence of the HLA class II transgene. These mice will allow further study of the role of these HLA molecules in vivo. We now have a much greater general understanding of the possible reasons why particular molecules may encode susceptibility to or protection from disease. All these studies will provide information to ultimately define a rational basis for the development of targeted immunotherapy.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Wong FS,Wen Ldoi
10.2174/1566524033361591keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
1-15issue
1eissn
1566-5240issn
1875-5666journal_volume
3pub_type
杂志文章,评审abstract:PURPOSE:Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacifi...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524017666170331163751
更新日期:2017-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190112143636
更新日期:2018-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524023362177
更新日期:2002-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652410793937741
更新日期:2010-12-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524043360654
更新日期:2004-06-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666141015153519
更新日期:2014-01-01 00:00:00
abstract::Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in treatment of cancer patients are still required. Utilization of microorganisms particularly bacteria h...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524020999200817113730
更新日期:2020-08-17 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
abstract::Traditionally regarded as a genetic disease of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease and a significant cause of sudden cardiac death. While the most common etiologies of this phenotypically diverse disease lie in a handful of genes encoding critica...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/156652412800620020
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190315164120
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:A small molecular compound, aminooxy-acetic acid (AOA), has been shown to modulate experimental autoimmune encephalomyelitis (EAE). The current study was designed to investigate whether AOA has a similar effect on the development of experimental autoimmune uveitis (EAU) and to further explore underlying mechani...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524020666200211112219
更新日期:2020-01-01 00:00:00
abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of m...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666140724102301
更新日期:2014-01-01 00:00:00
abstract::Citrate is one of the major substrates for intracellular metabolism. The extracellular level of citrate is stable in blood but varies locally, with slightly increased levels in brain and high levels in prostate. Recent metabolomics research suggests that citrate level is a potential harbinger of different pathophysiol...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524016666151123104855
更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524013363573
更新日期:2001-09-01 00:00:00
abstract::p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is ma...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652408786733748
更新日期:2008-12-01 00:00:00
abstract::As tumors progress to increased malignancy, cells within them develop the ability to invade into surrounding normal tissues and through tissue boundaries to form new growths (metastases) at sites distinct from the primary tumor. The molecular mechanisms involved in this process are incompletely understood but those as...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524033479447
更新日期:2003-11-01 00:00:00
abstract::p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
abstract:PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190918160032
更新日期:2019-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524015666151026100339
更新日期:2015-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524043359827
更新日期:2004-12-01 00:00:00
abstract::The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
abstract::Enteroviruses are common human pathogens involved in a wide spectrum of clinical outcomes ranging from mild or non-symptomatic illness to severe diseases with neurological and/or cardiac manifestation. Despite being responsible for significant morbidity and mortality especially in immunocompromised patients and infant...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
abstract::The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various grou...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::There has been prolonged and significant interest in manipulating the genome for a wide range of applications in biomedical research and medicine. An existing challenge in realizing this potential has been the inability to precisely edit specific DNA sequences. Past efforts to generate targeted double stranded DNA cle...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract::Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Current molecular medicine
pub_type: 杂志文章,评审
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更新日期:2005-05-01 00:00:00
abstract::The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666141202161326
更新日期:2014-01-01 00:00:00