Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug.

abstract：:Liver cirrhosis, an end-result of a wide variety of the liver diseases, is a world wide health problem. Because of its unique organ system, i.e., portal blood supply, bile formation and enterohepatic circulation, drug metabolism system, and sinusoidal lining cells such as Kupffer, endothelial and stellate cells, the l...

journal_title：Current molecular medicine

authors： Higuchi H,Gores GJ

更新日期：2003-09-01 00:00:00

abstract：:Necrotic cell death has long been considered an accidental and uncontrolled mode of cell death. But recently it has become clear that necrosis is a molecularly regulated event that is associated with pathologies such as ischemia-reperfusion (IR) injury, neurodegeneration and pathogen infection. The serine/threonine ki...

journal_title：Current molecular medicine

authors： Vanlangenakker N,Vanden Berghe T,Krysko DV,Festjens N,Vandenabeele P

更新日期：2008-05-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, ...

journal_title：Current molecular medicine

authors： Chakraborty C,Shah KD,Cao WG,Hsu CH,Wen ZH,Lin CS

更新日期：2010-11-01 00:00:00

abstract：:Autophagy is a bulk cytosolic degradative process which in the last few years has become a key pathway for the advancement of molecular medicine. Autophagy (cellular self-eating) has several implications in human disorders involving accumulation of cytosolic protein aggregates such as Alzheimer, Parkinson, Huntington ...

journal_title：Current molecular medicine

authors： Lerena C,Calligaris SD,Colombo MI

更新日期：2008-03-01 00:00:00

abstract：:Chondroitin sulfate (CS)-glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides attached to CS proteoglycans that make up a major component of biological matrices throughout both central and peripheral tissues. The position of their attached sulfate groups to the CS disaccharide is predicted to influ...

journal_title：Current molecular medicine

authors： Alonge K,Harkewicz R,Guttman M

更新日期：2020-09-15 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) and related neuropathies are a genetically highly heterogeneous group of neurodegenerative disorders. CMT affects both the sensory and motor nerves, distal Hereditary Motor Neuropathies (dHMN) are phenotypically similar disorders involving only motor nerves, while Hereditary Sensory a...

journal_title：Current molecular medicine

authors： Pareyson D,Saveri P,Piscosquito G

更新日期：2014-01-01 00:00:00

abstract：:Spider venom is a large pharmacological repertoire containing many biologically active peptides, which may have a potent therapeutic implication. Here we investigated a peptide toxin, named lycosin-I, isolated from the venom of the spider Lycosa singoriensis. In contrast to most spider peptide toxins adopting inhibito...

journal_title：Current molecular medicine

authors： Liu Z,Deng M,Xiang J,Ma H,Hu W,Zhao Y,Li DW,Liang S

更新日期：2012-12-01 00:00:00

abstract：:Our current understanding of the mechanisms of information processing and storage in the brain, based on the concept proposed more than fifty years ago by D. Hebb, is that a key role is played by changes in synaptic efficacy induced by coincident pre- and postsynaptic activity. Decades of studies of the properties of ...

journal_title：Current molecular medicine

authors： Muller D,Nikonenko I,Jourdain P,Alberi S

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology. OBJECTIVES:To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers o...

journal_title：Current molecular medicine

authors： Taha IM,Allah AMA,El Tarhouny S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper imm...

journal_title：Current molecular medicine

authors： Zou Y,Chen Q,Ye Z,Li X,Ju R

更新日期：2017-12-07 00:00:00

abstract：:Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a n...

journal_title：Current molecular medicine

authors： Crooke ST

更新日期：2004-08-01 00:00:00

abstract：:The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various grou...

journal_title：Current molecular medicine

authors： Abdel-Rahman WM,Faris ME,Peltomaki P

更新日期：2017-01-01 00:00:00

abstract：:p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...

journal_title：Current molecular medicine

authors： Pellegrini M,Baldari CT

更新日期：2009-04-01 00:00:00

abstract：:The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has been implicated in various functions, including apop...

journal_title：Current molecular medicine

authors： Veenman L,Gavish M

更新日期：2012-05-01 00:00:00

abstract：:Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...

journal_title：Current molecular medicine

authors： Liu PF,Huang IF,Shu CW,Huang CM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

journal_title：Current molecular medicine

authors： Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

更新日期：2020-01-01 00:00:00

abstract：:HIV infection causes an acquired immunodeficiency, principally because of depletion of CD4 lymphocytes. The mechanism by which the virus depletes these cells, however, is not clearly understood. Since the virus predominantly infects CD4 lymphocytes in vivo, some have assumed that HIV replication directly kills the inf...

journal_title：Current molecular medicine

authors： Cloyd MW,Chen JJ,Adeqboyega P,Wang L

更新日期：2001-11-01 00:00:00

abstract：:Despite advances in biomedical sciences, the prognosis of patients with brain tumors remains poor. Effective treatment is lacking for these central nervous system (CNS) cancers. Targeted immunotoxins are a new class of therapeutic approaches that have emerged for the treatment of human cancers. In this approach, tumor...

journal_title：Current molecular medicine

authors： Puri S,Puri S,Mahapatra AK,Hussain E,Sarkar C,Sinha S,Joshi BH

更新日期：2009-08-01 00:00:00

abstract：:Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry. The severity and the outcome of a systemic Salmonella infection depends on the "virulence" of the bacteria, on the infectious dose as well as on the genetic makeup and immunological...

journal_title：Current molecular medicine

authors： Mastroeni P

更新日期：2002-06-01 00:00:00

abstract：:Skin is a complex tissue composed of two very different compartments -- the continuously renewing epidermis made up mostly by keratinocytes and the underlying matrix-rich dermis with the resting fibroblasts as its major cellular components. Both compartments are tightly interconnected and a paracrine mutual interactio...

journal_title：Current molecular medicine

authors： Boukamp P

更新日期：2005-03-01 00:00:00

abstract：:A major benefit of the genomics revolution in biomedical research has been the establishment of transcriptome analysis as an enabling technology in the drug development process. Nowhere in the realm of drug development has the expectation of the impact of transcriptome analysis been greater than in the area of pre-cli...

journal_title：Current molecular medicine

authors： Searfoss GH,Ryan TP,Jolly RA

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

journal_title：Current molecular medicine

authors： Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

更新日期：2014-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific destruction of insulin-producing pancreatic beta-cells, culminating in a state of hypoinsulinemia and hyperglycemia. Pathogenesis of T1D comprises complex series of events from the initial sensitization of antigen-presenting cell...

journal_title：Current molecular medicine

authors： Kim HS,Lee MS

更新日期：2009-02-01 00:00:00

abstract：:The unexpected encounter between the fields of HIV and chemokines has opened new perspectives for understanding the mechanisms of AIDS pathogenesis, as well as for the development of effective therapies and vaccines. Selected chemokines act as potent natural inhibitors of HIV infection, as they bind and downmodulate c...

journal_title：Current molecular medicine

authors： Verani A,Lusso P

更新日期：2002-12-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：:Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated....

journal_title：Current molecular medicine

authors： Ma H,Sinha B,Pandya RS,Lin N,Popp AJ,Li J,Yao J,Wang X

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Lauric acid (LA) has antimicrobial effects and the potential to replace antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The effects of lauric acid on the intestinal epithelial cells remain unclear. METHODS AND RESULTS:This study investigates the effects of LA on...

journal_title：Current molecular medicine

authors： Yang Y,Huang J,Li J,Yang H,Yin Y

更新日期：2020-01-01 00:00:00

abstract：:Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...

journal_title：Current molecular medicine

authors： Takimoto Y,Inui A,Kumano H,Kuboki T

更新日期：2003-06-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Respo...

journal_title：Current molecular medicine

authors： Rozpedek W,Pytel D,Mucha B,Leszczynska H,Diehl JA,Majsterek I

更新日期：2016-01-01 00:00:00