Abstract:
:Autophagy is a bulk cytosolic degradative process which in the last few years has become a key pathway for the advancement of molecular medicine. Autophagy (cellular self-eating) has several implications in human disorders involving accumulation of cytosolic protein aggregates such as Alzheimer, Parkinson, Huntington diseases, as well as in myopathies caused by deficient lysosomal functions and in cancer. Moreover, autophagy affects intracellular microorganism lifespan, acting either as a cellular defense mechanism or, on the contrary, promoting pathogen replication. Furthermore, autophagy also participates in antigen presentation, as a part of the adaptive immune response. Therefore, autophagy association with cell survival or cell death would depend on cell nutrition conditions, presence of cell intruders, and alterations in oncogene or suppressor gene expression. In this review we will focus on the wide spectra of disease-related topics where autophagy is involved, particularly, in those processes concerning microorganism infections.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Lerena C,Calligaris SD,Colombo MIdoi
10.2174/156652408783769634subject
Has Abstractpub_date
2008-03-01 00:00:00pages
92-101issue
2eissn
1566-5240issn
1875-5666journal_volume
8pub_type
杂志文章,评审abstract::Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry. The severity and the outcome of a systemic Salmonella infection depends on the "virulence" of the bacteria, on the infectious dose as well as on the genetic makeup and immunological...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524023362492
更新日期:2002-06-01 00:00:00
abstract::Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct program...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524020666200421115251
更新日期:2020-04-21 00:00:00
abstract::Genome-wide association studies (GWAS) have become increasingly widely used to determine regions of the genome which may contain loci influencing the risk of neurological disorders. While linkage studies have identified genes that cause a number of Mendelian disorders, linkage analysis is less well suited for the more...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652409789105534
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Accumulated evidence have well established that protein sumoylation plays multiple roles in various cellular processes. In the vertebrate eye, we and others have demonstrated that sumoylation displays indispensable roles in regulating eye development. Various ocular cell lines including human embryonic cell lin...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190107153440
更新日期:2018-01-01 00:00:00
abstract::The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retina...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652409789712783
更新日期:2009-11-01 00:00:00
abstract::The endoplasmic reticulum (ER) provides unique machinery for the folding and posttranslational modification of many secretory and transmembrane proteins in eukaryotic cells. The unfolded protein response (UPR) is a signal transduction network from the ER to the nucleus activated when the folding demand imposed by nasc...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652406775574569
更新日期:2006-02-01 00:00:00
abstract::In recent years, the clinical validation of molecular targeted therapies inhibiting the action of pathogenic tyrosine kinase (TK) has been one of the most exciting developments in cancer research. In this context, medullary thyroid carcinoma (MTC) represents a promising model. It is well known that in MTC, the RET rec...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652410792630607
更新日期:2010-10-01 00:00:00
abstract::Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652411795976583
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190918160032
更新日期:2019-01-01 00:00:00
abstract::Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced ap...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524013363780
更新日期:2001-07-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652410790963321
更新日期:2010-03-01 00:00:00
abstract::Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nut...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524033479762
更新日期:2003-06-01 00:00:00
abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of m...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524014666140724102301
更新日期:2014-01-01 00:00:00
abstract::The view that mitochondrial electron transport is the only site of aerobic respiration and the primary bioenergetic pathway in mammalian cells is well established in the literature. Although this paradigm is widely accepted for most tissues, the situation is less clear for proliferating cells. Increasing evidence indi...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652406779010777
更新日期:2006-12-01 00:00:00
abstract::Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited polycythaemia. VHL disease is a multisystem familial cancer syndrome and is the commonest cause of familial renal cell carcinoma (RCC). VHL disease ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524043359827
更新日期:2004-12-01 00:00:00
abstract::Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and g...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524018666181008112738
更新日期:2018-01-01 00:00:00
abstract::Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652409787581583
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190126112238
更新日期:2018-01-01 00:00:00
abstract::The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a cancer cell-specific pro-apoptotic activity. This property made the TRAIL associated pathway one of the most promising strategies aimed at inducing tumor-selective death. In fact, several approaches have been considered to explore this pathwa...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652413804810727
更新日期:2013-02-01 00:00:00
abstract::By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Re...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524015666151026100339
更新日期:2015-01-01 00:00:00
abstract::Necrotic cell death has long been considered an accidental and uncontrolled mode of cell death. But recently it has become clear that necrosis is a molecularly regulated event that is associated with pathologies such as ischemia-reperfusion (IR) injury, neurodegeneration and pathogen infection. The serine/threonine ki...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652408784221306
更新日期:2008-05-01 00:00:00
abstract::Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652411794859278
更新日期:2011-03-01 00:00:00
abstract::Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/15665240113139990063
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666190424143653
更新日期:2019-01-01 00:00:00
abstract::As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobuli...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524043479329
更新日期:2004-02-01 00:00:00
abstract::As tumors progress to increased malignancy, cells within them develop the ability to invade into surrounding normal tissues and through tissue boundaries to form new growths (metastases) at sites distinct from the primary tumor. The molecular mechanisms involved in this process are incompletely understood but those as...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524033479447
更新日期:2003-11-01 00:00:00
abstract::Type 2 Diabetes occurs as a result of defects in insulin secretion and its function. Although mechanisms of disease are not fully elucidated, it is recognized that a progressive decline in insulin secretory capacity is responsible for its occurrence and natural course. Metabolic syndrome, known to be a precursor of Ty...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652409787847245
更新日期:2009-04-01 00:00:00
abstract::Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokin...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/1566524018666180705114131
更新日期:2018-01-01 00:00:00
abstract::Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by st...
journal_title:Current molecular medicine
pub_type: 杂志文章,评审
doi:10.2174/156652407781387136
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal (ICC) in colon tissues of rabbits. METHODS:Thirty rabbits were randomly divided into five groups (n=6, each group): saline control group (NS group), low concentration of...
journal_title:Current molecular medicine
pub_type: 杂志文章
doi:10.2174/1566524019666191023112837
更新日期:2020-01-01 00:00:00