Abstract:
:Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and genetic factors have apparent roles in the process. Accurate diagnosis is important to properly identify and stratify the disease, however, MM identification steps are time-consuming and expensive. Thus, development of early molecular diagnostic methods is of high importance in order to start proper therapies as early in the disease progression as possible, given the nature of the poor survival rates/remission periods. Molecular diagnostics via analytical omics represents one of the promising toolsets to speed up the diagnostic process. In this paper, we critically review the utilization of state of the art, high sensitivity analytical omics approaches (genomics, proteomics, metabolomics, lipidomics and glycomics) in MM diagnostics at the molecular level.
journal_name
Curr Mol Medjournal_title
Current molecular medicineauthors
Kovacs Z,Guttman Adoi
10.2174/1566524018666181008112738subject
Has Abstractpub_date
2018-01-01 00:00:00pages
260-272issue
4eissn
1566-5240issn
1875-5666pii
CMM-EPUB-93488journal_volume
18pub_type
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