Posttranscriptional regulation of p53 and its targets by RNA-binding proteins.

abstract：BACKGROUND:Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper imm...

journal_title：Current molecular medicine

authors： Zou Y,Chen Q,Ye Z,Li X,Ju R

更新日期：2017-12-07 00:00:00

abstract：:A critical challenge faced by clinical nephrologists today is the escalating number of patients developing end stage renal disease, a major proportion of which is attributed to diabetic nephropathy (DN). The need for new measures to prevent and treat this disease cannot be overemphasized. To this end, modern genetic a...

journal_title：Current molecular medicine

authors： Ng DP,Krolewski AS

更新日期：2005-08-01 00:00:00

abstract：:A major benefit of the genomics revolution in biomedical research has been the establishment of transcriptome analysis as an enabling technology in the drug development process. Nowhere in the realm of drug development has the expectation of the impact of transcriptome analysis been greater than in the area of pre-cli...

journal_title：Current molecular medicine

authors： Searfoss GH,Ryan TP,Jolly RA

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Plasmid DNA has been widely used in vaccination as well as in cell and gene therapy. It exists in multiple isoforms, including supercoiled, nicked or open circular and linear forms. Regulatory agencies recommend having more than 80% of the supercoiled isoform for the bulk release of plasmid products; thus, i...

journal_title：Current molecular medicine

authors： Cook KS,Luo J,Guttman A,Thompson L

更新日期：2020-04-27 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The study aimed to evaluate the preventive effects of hydroxycitric acid（HCA） for stone formation in the glyoxylate-induced mouse model. MATERIALS AND METHODS:Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood...

journal_title：Current molecular medicine

authors： Liu X,Yuan P,Sun X,Chen Z

更新日期：2020-01-01 00:00:00

abstract：:Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry. The severity and the outcome of a systemic Salmonella infection depends on the "virulence" of the bacteria, on the infectious dose as well as on the genetic makeup and immunological...

journal_title：Current molecular medicine

authors： Mastroeni P

更新日期：2002-06-01 00:00:00

abstract：:In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...

journal_title：Current molecular medicine

authors： Pan J,Liu H,Zhou J,Liu Z,Yang Y,Peng Y,You H,Yang D,Xie P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug. METHODS:In addition, removal of emerging drug contaminants from wastewaters is a necessity that sho...

journal_title：Current molecular medicine

authors： Fu M,Tayebee R,Saberi S,Nourbakhsh N,Esmaeili E,Maleki B,Vatanpour HR

更新日期：2021-01-10 00:00:00

abstract：:Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, ...

journal_title：Current molecular medicine

authors： Chakraborty C,Shah KD,Cao WG,Hsu CH,Wen ZH,Lin CS

更新日期：2010-11-01 00:00:00

abstract：:Many autoimmune diseases have genetic associations with the Major Histocompatibility Complex (MHC) class II loci. Susceptibility to Type 1 diabetes mellitus (TIDM) is particularly associated with Human Leucocyte Antigen (HLA) DR3, 4 and associated DQ2, 8 alleles and this is well documented in genetic association studi...

journal_title：Current molecular medicine

authors： Wong FS,Wen L

更新日期：2003-02-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent disorder defined by the presence of chronic widespread pain in association with fatigue, sleep disturbances and cognitive dysfunction. Recent studies indicate that bipolar spectrum disorders frequently co-occur in individuals with FM. Furthermore, shared pathophysiological mechanisms a...

journal_title：Current molecular medicine

authors： Bortolato B,Berk M,Maes M,McIntyre RS,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1-ind...

journal_title：Current molecular medicine

authors： Rauvala H,Rouhiainen A

更新日期：2007-12-01 00:00:00

abstract：:Gastric cancer is thought to result from a combination of environmental factors and the accumulation of specific genetic alterations due to increasing genetic instability, and consequently affects mainly older patients. Less than 10% of patients present with the disease before 45 years of age (early onset gastric carc...

journal_title：Current molecular medicine

authors： Milne AN,Sitarz R,Carvalho R,Carneiro F,Offerhaus GJ

更新日期：2007-02-01 00:00:00

abstract：:A framework was developed to provide an integrated view of mycobacterial growth and its regulation. The topics reviewed include the properties of cell cultures and their relation to properties of individual cells, cell sizes and macromolecular compositions, uptake of nutrients through the cell envelope, protein biosyn...

journal_title：Current molecular medicine

authors： Cox RA,Cook GM

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhi...

journal_title：Current molecular medicine

authors： Hu X,Schewitz-Bowers LP,Lait PJP,Copland DA,Stimpson ML,Li JJ,Liu Y,Dick AD,Lee RWJ,Wei L

更新日期：2018-01-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disorder (COPD), and cystic fibrosis (CF), chronic diseases of the airways, are characterized by symptoms such as inflammation of the lung tissue, mucus hypersecretion, constriction of the airways, and excessive fibrosis of airway tissue. Transforming growth factor (TGF)-beta, a c...

journal_title：Current molecular medicine

authors： Moore B,Murphy RF,Agrawal DK

更新日期：2008-08-01 00:00:00

abstract：:Traditionally regarded as a genetic disease of the cardiac sarcomere, hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease and a significant cause of sudden cardiac death. While the most common etiologies of this phenotypically diverse disease lie in a handful of genes encoding critica...

journal_title：Current molecular medicine

authors： Landstrom AP,Ackerman MJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear. METHODS:Whole-mount in situ hybridization and embryo immunostaining were performed. RESULTS:Zebrafish Fhl1A is the homologue of human F...

journal_title：Current molecular medicine

authors： Chen F,Yuan W,Mo X,Zhuang J,Wang Y,Chen J,Jiang Z,Zhu X,Zeng Q,Wan Y,Li F,Shi Y,Cao L,Fan X,Luo S,Ye X,Chen Y,Dai G,Gao J,Wang X,Xie H,Zhu P,Li Y,Wu X

更新日期：2017-01-01 00:00:00

abstract：:The central role of glutamate receptors in mediating excitotoxic neuronal death in stroke, epilepsy and trauma has been well established. Glutamate is the major excitatory amino acid transmitter within the CNS and it's signaling is mediated by a number of postsynaptic ionotropic and metabotropic receptors. Although ca...

journal_title：Current molecular medicine

authors： Aarts MM,Tymianski M

更新日期：2004-03-01 00:00:00

abstract：:Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential relationship between the expression levels of GHRH-R and the placental...

journal_title：Current molecular medicine

authors： Liu AX,Zhang D,Zhu YM,Gao HJ,Jiang JY,Hu XL,Lv PP,Leung PC,Huang HF

更新日期：2016-01-01 00:00:00

abstract：:Citrate is one of the major substrates for intracellular metabolism. The extracellular level of citrate is stable in blood but varies locally, with slightly increased levels in brain and high levels in prostate. Recent metabolomics research suggests that citrate level is a potential harbinger of different pathophysiol...

journal_title：Current molecular medicine

authors： Mycielska ME,Milenkovic VM,Wetzel CH,Rümmele P,Geissler EK

更新日期：2015-01-01 00:00:00

abstract：:Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and DesArg(9) bradykinin. It does so by cleaving a C-terminal PRO-X bond. Recent work also indicates that the human PRCP1 activates plasma prekallikrein (PK) to kallikr...

journal_title：Current molecular medicine

authors： Wang J,Matafonov A,Madkhali H,Mahdi F,Watson D,Schmaier AH,Gailani D,Shariat-Madar Z

更新日期：2014-01-01 00:00:00

abstract：:Prostate cancer is one of the most difficult cancers to treat especially when it becomes hormone resistant such as castrate resistant prostate cancer (CRPC) and subsequent metastatic CRPC. Apart from the genetic alterations in prostate cancer, epigenetic modifications also play an important role in the development and...

journal_title：Current molecular medicine

authors： Giudice A,Montella M,Boccellino M,Crispo A,D'Arena G,Bimonte S,Facchini G,Ciliberto G,Botti G,Quagliuolo L,Caraglia M,Capunzo M

更新日期：2017-01-01 00:00:00

abstract：:Protein serine/threonine phosphatase-1 (PP-1) is one of the key enzymes responsible for dephosphorylation in vertebrates. Protein dephosphorylation via PP-1 is implicated in many different biological processes including gene expression, cell cycle control, transformation, neuronal transmission, apoptosis, autophage an...

journal_title：Current molecular medicine

authors： Liu WB,Yan Q,Liu FY,Tang XC,Chen HG,Liu J,Nie L,Zhang XW,Ji WK,Hu XH,Hu WF,Woodward Z,Wu KL,Wu MX,Liu XL,Luo LX,Yu MB,Liu YZ,Liu SJ,Li DW

更新日期：2012-12-01 00:00:00

abstract：:The world is aging and we must face the challenges that this brings. One of the reasons for the increasing aging of the world's population is the increase in life expectancy and, since we live longer, it is of paramount importance to live well and to prevent age-associated diseases. In this way, it is crucial to impro...

journal_title：Current molecular medicine

authors： Magalhaes S,Goodfellow BJ,Nunes A

更新日期：2018-01-01 00:00:00

abstract：:Tumor-derived exosomes contain biological contents such as proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA for intracellular communication. Meanwhile, studies have shown the role of exosomes in cancer progression, metastasis, and therapeutic resistance. Furthermore, tumor exosomes have received growing attentio...

journal_title：Current molecular medicine

authors： Nooshabadi VT,Arab S

更新日期：2020-11-20 00:00:00

abstract：:PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol...

journal_title：Current molecular medicine

authors： De Melo J,He L,Tang D

更新日期：2014-01-01 00:00:00

abstract：:Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...

journal_title：Current molecular medicine

authors： Liu PF,Huang IF,Shu CW,Huang CM

更新日期：2013-09-01 00:00:00

abstract：:The cell adhesion molecule integrin αvβ3 is an important player in the process of angiogenesis. In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin αvβ3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) ...

journal_title：Current molecular medicine

authors： Liu Z,Wang F

更新日期：2013-12-01 00:00:00