RAGE as a receptor of HMGB1 (Amphoterin): roles in health and disease.

abstract：:Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific destruction of insulin-producing pancreatic beta-cells, culminating in a state of hypoinsulinemia and hyperglycemia. Pathogenesis of T1D comprises complex series of events from the initial sensitization of antigen-presenting cell...

journal_title：Current molecular medicine

authors： Kim HS,Lee MS

更新日期：2009-02-01 00:00:00

abstract：:Mistletoe is often used as complementary therapy in oncology. The anti-tumor effects of mistletoe (Iscador) are well documented in-vitro in respect to inhibition of cell proliferation, induction of apoptosis, segmental activation of immune competent cells and trapping of chemotherapeutic drugs within cancer cells by m...

journal_title：Current molecular medicine

authors： Matthes H,Friedel WE,Bock PR,Zänker KS

更新日期：2010-06-01 00:00:00

abstract：:Ca2+ ions are involved in the regulation of many diverse functions in animal and plant cells, e.g. muscle contraction, secretion of neurotransmitters, hormones and enzymes, fertilization of oocytes, and lymphocyte activation and proliferation. The intracellular Ca2+ concentration can be increased by different molecula...

journal_title：Current molecular medicine

authors： Guse AH

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Interleukins IL1ß/IL18 and Inflammasome NLRP1/NLRP3 polymorphisms can change the course of multiple human diseases, both inflammatory as infectious. SNPs these proteins were associated with the constructive activation of the Inflammasome and excessive production of IL-1β induce a serious autoinflammatory dis...

journal_title：Current molecular medicine

authors： de Almeida E,Frantz SR,Cesar P,Tarragô AM,de Amorim Xabregas L,Garcia NP,Costa AG,de Paula EV,Malheiro A

更新日期：2019-01-01 00:00:00

abstract：:T cells, as they develop in the thymus come to express antigen receptors. The specificity of these receptors cannot be predicted and must include many with potential anti-self reactivity. Those that encounter self-antigens, in association with self-MHC (major histocompatibility complex), with high affinity are inactiv...

journal_title：Current molecular medicine

authors： Huang FP,MacPherson GG

更新日期：2001-09-01 00:00:00

abstract：:The generation of functional neural progenitor cells (NPCs) independent of donor brain tissue and embryonic tissues is of great therapeutic interest with regard to regenerative medicine and the possible treatment of neurodegenerative disorders. Traditionally, NPCs are derived through the differentiation of embryonic s...

journal_title：Current molecular medicine

authors： Tian C,Ambroz RJ,Sun L,Wang Y,Ma K,Chen Q,Zhu B,Zheng JC

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a well-known regulator of genotoxic stress-induced apoptosis, which is constitutively cleaved into three main fragments: PIDD-N, PIDD-C and PIDD-CC. Thus, we aim to determi...

journal_title：Current molecular medicine

authors： Zhang M,Chen L,Xu F,Jiang L,Yan W,Kunwar B,Tang F,Yang K,Shen C,Huang H,Lv J,Qin C,Wu X,Zeng S,Li M,Zhong S,Chen Q

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Accumulated evidence have well established that protein sumoylation plays multiple roles in various cellular processes. In the vertebrate eye, we and others have demonstrated that sumoylation displays indispensable roles in regulating eye development. Various ocular cell lines including human embryonic cell lin...

journal_title：Current molecular medicine

authors： Liu Y,Zhang L,Tang X,Liu F,Fu JL,Gong XD,Wang L,Nie Q,Xiang JW,Xiao Y,Liu Y,Li DW

更新日期：2018-01-01 00:00:00

abstract：:Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety of mechanisms are involved in PDAC biological behaviors, of which, the mechanisms of immune escape may be a pivotal hallmark. HLA-G is a tolerant molecule implicated in tumor escape and serves as a prognostic biomarker in ...

journal_title：Current molecular medicine

authors： Xu YF,Lu Y,Cheng H,Jiang J,Xu J,Long J,Liu L,Ni Q,Liu C,Yu XJ

更新日期：2015-01-01 00:00:00

abstract：:Halitosis (bad breath) is estimated to influence more than half of the world's population with varying degree of intensity. More than 85% of halitosis originates from oral bacterial infections. Foul-smelling breath mainly results from bacterial production of volatile sulfur compounds (VSCs) such as hydrogen sulfide an...

journal_title：Current molecular medicine

authors： Liu PF,Huang IF,Shu CW,Huang CM

更新日期：2013-09-01 00:00:00

abstract：:Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Respo...

journal_title：Current molecular medicine

authors： Rozpedek W,Pytel D,Mucha B,Leszczynska H,Diehl JA,Majsterek I

更新日期：2016-01-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism ...

journal_title：Current molecular medicine

authors： Aso Y

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To date, no comprehensive systematic review investigating genetic risk factors for familial a...

journal_title：Current molecular medicine

authors： Sidenna M,Bux R,Fadl T,Ozbek U,Zayed H

更新日期：2020-01-01 00:00:00

abstract：:Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making ...

journal_title：Current molecular medicine

authors： Saxena N,Chandra NC

更新日期：2020-01-01 00:00:00

abstract：:In recent years, the clinical validation of molecular targeted therapies inhibiting the action of pathogenic tyrosine kinase (TK) has been one of the most exciting developments in cancer research. In this context, medullary thyroid carcinoma (MTC) represents a promising model. It is well known that in MTC, the RET rec...

journal_title：Current molecular medicine

authors： Torino F,Paragliola RM,Barnabei A,Corsello SM

更新日期：2010-10-01 00:00:00

abstract：:Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...

journal_title：Current molecular medicine

authors： Be NA,Kim KS,Bishai WR,Jain SK

更新日期：2009-03-01 00:00:00

abstract：:Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...

journal_title：Current molecular medicine

authors： Boyce JA

更新日期：2008-08-01 00:00:00

abstract：:Skeletal mass is regulated by the coordinated action of bone forming osteoblasts and bone resorbing osteoclasts. Accelerated rates of bone resorption relative to bone formation lead to net bone loss and the development of osteoporosis, a devastating disease that predisposes the skeleton to fractures. Bone fractures ar...

journal_title：Current molecular medicine

authors： Yamaguchi M,Vikulina T,Arbiser JL,Weitzmann MN

更新日期：2014-01-01 00:00:00

abstract：:The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retina...

journal_title：Current molecular medicine

authors： Tolentino MJ

更新日期：2009-11-01 00:00:00

abstract：:There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposur...

journal_title：Current molecular medicine

authors： Møller P,Folkmann JK,Danielsen PH,Jantzen K,Loft S

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To detect mutations of trypsinogen gene (PRSS1) in patients with autoimmune pancreatitis (AIP) and to determine the underlying pathogenesis. METHODS:DNA sequencing was used to detect full-length of PRSS1, cystic fibrosis transmembrane conductance regulator (CFTR), and pancreatic secretory trypsin inhibitor (...

journal_title：Current molecular medicine

authors： Gao F,Li Y,Wang C,Zhuang Z,Liu QC,Chen J,Hong G,Xu Z

更新日期：2014-03-01 00:00:00

abstract：:In this study, a two-dimensional gel-based proteomic approach was applied to profile the protein alterations underlying the significant adverse effects from post-stroke depression (PSD). In view of the close association between left prefrontal cortical dysfunction and PSD, a PSD rat model was constructed through a lef...

journal_title：Current molecular medicine

authors： Pan J,Liu H,Zhou J,Liu Z,Yang Y,Peng Y,You H,Yang D,Xie P

更新日期：2014-01-01 00:00:00

abstract：:Glycogen is a branched polymer of glucose which serves as a reservoir of glucose units. The two largest deposits in mammals are in the liver and skeletal muscle but many cells are capable synthesizing glycogen. Its accumulation and utilization are under elaborate controls involving primarily covalent phosphorylation a...

journal_title：Current molecular medicine

authors： Roach PJ

更新日期：2002-03-01 00:00:00

abstract：:Immune tolerance can be induced by numerous methods. This review article aims to draw lines of similarity and contrast between two unique models of immune tolerance, namely Anterior Chamber Associated Immune Deviation (ACAID) and Nickel-induced oral tolerance. ACAID is an immune tolerance model that leads to the gener...

journal_title：Current molecular medicine

authors： Ashour HM

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. The purpose of this study is to determine whether there is protective autophagy after celastrol treatment in pancreatic cancer cells and the synergistic effects of celastrol and 3-MA in vitro and in vivo. METHODS:T...

journal_title：Current molecular medicine

authors： Zhao X,Gao S,Ren H,Huang H,Ji W,Hao J

更新日期：2014-05-01 00:00:00

abstract：:Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional roles in the control of key cellular events such as adhesion, migration, proliferation, differentiation, and survival. In tumors, matrix effectors such as proteogl...

journal_title：Current molecular medicine

authors： Skandalis SS,Aletras AJ,Gialeli C,Theocharis AD,Afratis N,Tzanakakis GN,Karamanos NK

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Photoreceptor cell death is a key pathology of retinal degeneration diseases. To date, the molecular mechanisms for this pathological process remain largely unclear. Junctional adhesion molecule-c (Jam-c) has been shown to play important roles in different biological events. However, its effect on retinal ne...

journal_title：Current molecular medicine

authors： Li Y,Zhang F,Lu W,Li X

更新日期：2018-03-09 00:00:00

abstract：:After several years of controversy, antibodies (Abs) are now believed to play an important role in the protection against fungal infections. Among them, recent data are strongly supporting the relevance of protective yeast killer toxin-like Abs ("antibiobodies", KT-Abs), which are able to exert a direct microbicidal a...

journal_title：Current molecular medicine

authors： Magliani W,Conti S,Frazzi R,Ravanetti L,Maffei DL,Polonelli L

更新日期：2005-06-01 00:00:00

abstract：:Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and lysophospholipids. Mammalian PLA2s are divided into two major classes according to their molecular mass and location: intracellular PLA2 a...

journal_title：Current molecular medicine

authors： Touqui L,Alaoui-El-Azher M

更新日期：2001-12-01 00:00:00