Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals.

abstract：:A model system was established for studies of humoral and cellular immunity to human immunodeficiency virus (HIV) antigens after vaccination. Macaques (Macaca fascicularis) were immunized with purified HIV, an infected cell extract rich in gp120 or polypeptides of cloned genes representing parts of p24, gp41, and gp12...

journal_title：AIDS research and human retroviruses

authors： Wahren B,Chiodi F,Ljunggren K,Putney S,Kurth R,Gallo RC,Fenyö EM

更新日期：1988-06-01 00:00:00

abstract：:HIV/hepatitis C virus (HCV) patients have a 3-fold increased fracture incidence compared to uninfected patients. The impact of HCV therapy on bone health is unclear. We evaluated bone turnover markers (BTM) in well-controlled (HIV RNA <50 copies/ml) HIV/HCV-coinfected patients who received pegylated interferon-α and r...

journal_title：AIDS research and human retroviruses

authors： Bedimo R,Kang M,Tebas P,Overton ET,Hollabaugh K,McComsey G,Bhattacharya D,Evans C,Brown TT,Taiwo B

更新日期：2016-04-01 00:00:00

abstract：:Human T cell leukemia virus type-1 (HTLV-1) is prevalent worldwide with foci of high prevalence. However, to date no effective vaccine or drug against HTLV-1 infection has been developed. In efforts to define the role of antibodies in the control of HTLV-1 infection, we capitalized on the use of our previously defined...

journal_title：AIDS research and human retroviruses

authors： Tanaka Y,Takahashi Y,Tanaka R,Kodama A,Fujii H,Hasegawa A,Kannagi M,Ansari AA,Saito M

更新日期：2014-06-01 00:00:00

abstract：:A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses and antibodies in nonhuman primates. In this rando...

journal_title：AIDS research and human retroviruses

authors： Mehendale S,van Lunzen J,Clumeck N,Rockstroh J,Vets E,Johnson PR,Anklesaria P,Barin B,Boaz M,Kochhar S,Lehrman J,Schmidt C,Peeters M,Schwarze-Zander C,Kabamba K,Glaunsinger T,Sahay S,Thakar M,Paranjape R,Gilmour J,

更新日期：2008-06-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is associated with lower serum concentration of low-density lipoprotein (LDL-C), the primary cholesterol metabolite targeted pharmaceutically to modulate cardiovascular risk. Chronic infection with human immunodeficiency virus (HIV) and treatment with antiretrovirals (ARVs) ar...

journal_title：AIDS research and human retroviruses

authors： Townsend K,Meissner EG,Sidharthan S,Sampson M,Remaley AT,Tang L,Kohli A,Osinusi A,Masur H,Kottilil S

更新日期：2016-05-01 00:00:00

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:The proportion of human immunodeficiency virus type 1 (HIV-1) among Vietnamese injecting drug users (IDUs) in Melbourne, Australia exceeds that of the background population. To investigate the molecular epidemiology of HIV-1 among this group, the C2-V4 region of the HIV-1 envelope was directly sequenced from 11 Vietna...

journal_title：AIDS research and human retroviruses

authors： Ryan CE,Elliott JH,Middleton T,Mijch AM,Street AC,Hellard M,Crofts N,Crowe SM,Oelrichs RB

更新日期：2004-12-01 00:00:00

abstract：:A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental subunit HIV-1 vaccine containing a truncated recombinant HIV-1 envelope protein (gp160D) adsorbed to alum. Antibody responses were meas...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Wu JY,Coughlin RT,Murphy CI,Seals JR,Wyand MS,Kensil CR

更新日期：1992-08-01 00:00:00

abstract：:Cytotoxic T cell determinants should be an important component of an anti-human immunodeficiency virus (HIV) vaccine. The epitopes of proteins can be defined with short synthetic peptides for class I-restricted CTLs. An immunodominant CTL epitope from the HIV-1 IIIB envelope protein gp160 comprising 15 amino acids (re...

journal_title：AIDS research and human retroviruses

authors： Achour A,Lemhammedi S,Picard O,M'Bika JP,Zagury JF,Moukrim Z,Willer A,Beix F,Burny A,Zagury D

更新日期：1994-01-01 00:00:00

abstract：:Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease progression. This is one of the regions on gp120 that interact with the transmembrane glycoprotein, gp41, anchoring it to the viral and infected cell membrane. This study...

journal_title：AIDS research and human retroviruses

authors： Sørensen B,Sommerfelt MA,Stjernholm G,Smith PL,Ökvist M,Hovden AO,Hoddevik G,Redfield R,Ustina V,Jelmert Ø,Zeldis J,Dalgleish A

更新日期：2017-06-01 00:00:00

abstract：:Subunit vaccines based on recombinant proteins have proved useful for inducing antibody responses and they are safe for widespread use because they do not contain any live components. Unfortunately, they do not typically induce the types of cell-mediated immune responses required to control viral pathogens; specifical...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Munroe KJ,Anderson CA,Murphy CI,Panicali DL,Seals JR,Wu JY,Wyand MS,Kensil CR

更新日期：1994-07-01 00:00:00

abstract：:In order to obtain more information about the presence of HIV-1 in mononuclear cells of colostrum, research was carried out on both the HIV-1 genome in the cellular fraction of colostrum and the viral antibody in cell-free colostrum of eight anti-HIV-1 seropositive asymptomatic mothers. In five cases cell fractions of...

journal_title：AIDS research and human retroviruses

authors： Vonesch N,Sturchio E,Humani AC,Cordiali Fei P,Cosenza D,Caprilli F,Pezzella M

更新日期：1992-07-01 00:00:00

abstract：:Zidovudine (ZDV) is converted to its active triphosphate (ZDVTP) by intracellular kinases. The intermediate ZDV monophosphate (ZDVMP) is believed to play a major role in ZDV toxicity. Manipulation of ZDV phosphorylation is a possible therapeutic strategy for altering the risk-benefit ratio. Here we investigate whether...

journal_title：AIDS research and human retroviruses

authors： Sim SM,Hoggard PG,Sales SD,Phiboonbanakit D,Hart CA,Back DJ

更新日期：1998-12-20 00:00:00

abstract：:Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1...

journal_title：AIDS research and human retroviruses

authors： Cheedarla N,Sundaramurthi JC,Hemalatha B,Anangi B,Nesakumar M,Ashokkumar M,Vidya Vijayan KK,Tripathy SP,Swaminathan S,Vaniambadi SK,Ramanathan DV,Hanna LE

更新日期：2019-02-01 00:00:00

abstract：:The Tax protein encoded by HTLV-1 plays a key role in the development of ATL in infected individuals. Our previous studies showed that tax transgenic mice develop disease that is almost identical to human ATL, with widespread organ invasion by lymphomatous cells and the development of leukemia. The same pathology deve...

journal_title：AIDS research and human retroviruses

authors： Watters KM,Dean J,Hasegawa H,Sawa H,Hall W,Sheehy N

更新日期：2010-05-01 00:00:00

abstract：:Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of an...

journal_title：AIDS research and human retroviruses

authors： Capobianchi MR,Ameglio F,Cordiali Fei P,Castilletti C,Mercuri F,Fais S,Dianzani F

更新日期：1993-10-01 00:00:00

abstract：:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on...

journal_title：AIDS research and human retroviruses

authors： Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

更新日期：2017-02-01 00:00:00

abstract：:HIV-specific CD4+ T cell responses, in particular to the HIV envelope antigen gp120, are often undetectable in the peripheral blood of HIV-infected individuals. The failure to detect these cells poses a significant impediment to studying the T cell populations that are considered to be essential for controlling HIV in...

journal_title：AIDS research and human retroviruses

authors： Cohen S,Tuen M,Hioe CE

更新日期：2003-09-01 00:00:00

abstract：:Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-1(92UG001), a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotyp...

journal_title：AIDS research and human retroviruses

authors： Novelli P,Vella C,Oxford J,Daniels RS

更新日期：2002-01-01 00:00:00

abstract：:HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

journal_title：AIDS research and human retroviruses

authors： Flemming J,Wiesen L,Herschhorn A

更新日期：2018-09-01 00:00:00

abstract：:CRF01_AE and subtype B have dominated the HIV-1 epidemic in Thailand since 1989. We reported a new circulating recombinant form of HIV-1, CRF15_01B, as well as other unique CRF01_AE/B recombinants among prevalent HIV infections in Thailand. We sought to study this challenging molecular picture through assessment of su...

journal_title：AIDS research and human retroviruses

authors： Tovanabutra S,Beyrer C,Sakkhachornphop S,Razak MH,Ramos GL,Vongchak T,Rungruengthanakit K,Saokhieo P,Tejafong K,Kim B,De Souza M,Robb ML,Birx DL,Jittiwutikarn J,Suriyanon V,Celentano DD,McCutchan FE

更新日期：2004-05-01 00:00:00

abstract：:Abstract Multiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype A, CRF01_AE, CRF06_cpx, and other complex intersubtype recombinants has been well documented. Mali, situated in the heart of West A...

journal_title：AIDS research and human retroviruses

authors： Imamichi H,Koita O,Dabitao D,Dao S,Ibrah M,Sogoba D,Dewar RL,Berg SC,Jiang MK,Parta M,Washington JA,Polis MA,Lane HC,Tounkara A

更新日期：2009-01-01 00:00:00

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag...

journal_title：AIDS research and human retroviruses

authors： Seddiki N,Ben Younes-Chennoufi A,Benjouad A,Saffar L,Baumann N,Gluckman JC,Gattegno L

更新日期：1996-05-20 00:00:00

abstract：:We used enzyme-linked immunosorbant assay (ELISA) and Western blotting, with "purified" human T-cell leukemia virus I (HTLV-I), to test for HTLV-I antibodies in 2583 plasma samples from 1053 leukemia/lymphoma patients treated at Roswell Park Memorial Institute, mostly between 1972 and 1984, and in 110 sera samples fro...

journal_title：AIDS research and human retroviruses

authors： Srivastava BI,Gonzales C,Loftus R,Fitzpatrick JE,Saxinger CW

更新日期：1990-05-01 00:00:00

abstract：:Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

journal_title：AIDS research and human retroviruses

authors： Sporer B,Koedel U,Goebel FD,Pfister HW

更新日期：2000-02-10 00:00:00

abstract：:Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral ...

journal_title：AIDS research and human retroviruses

authors： Kliks S,Contag CH,Corliss H,Learn G,Rodrigo A,Wara D,Mullins JI,Levy JA

更新日期：2000-09-01 00:00:00

abstract：:We investigated a strategy for gene therapy, intracellular expression of anti-HIV-1 Rev single-chain variable fragments (SFvs), in promonocytic (U1) and T (ACH-2) cell lines latently infected with HIV-1. The cellular and molecular mechanisms leading to activation of latent integrated HIV-1 provirus in U1 and ACH-2 cel...

journal_title：AIDS research and human retroviruses

authors： Ho WZ,Lai JP,Bouhamdan M,Duan L,Pomerantz RJ,Starr SE

更新日期：1998-11-20 00:00:00

abstract：:Preexposure prophylaxis (PrEP) with antiretroviral drugs constitutes a promising strategy for HIV prevention. Potent PrEP regimens with reverse transcriptase inhibitors can prevent detectable SHIV infection in a repeated low-dose macaque model that resembles human transmission, supporting plans to quickly move this ap...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Luo W,Adams DR,Mitchell J,Garcia-Lerma JG,Heneine W,Folks TM,Butera S,Otten RA

更新日期：2008-04-01 00:00:00

abstract：:Human T lymphotropic virus type I trans-activator Tax protein regulates expression of several cellular genes that are involved in cellular activation, proliferation, and transformation. Tax mediates its regulatory activity through interaction with cellular transcription factors such as members of the cAMP-responsive e...

journal_title：AIDS research and human retroviruses

authors： Moriuchi M,Moriuchi H,Fauci AS

更新日期：1999-06-10 00:00:00