Abstract:
:Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. In addition, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity after mucosal exposure.
journal_name
AIDS Res Hum Retrovirusesjournal_title
AIDS research and human retrovirusesauthors
Selva KJ,Juno JA,Worley MJ,Chung AW,Tachedjian G,Kent SJ,Parsons MSdoi
10.1089/AID.2018.0219subject
Has Abstractpub_date
2019-06-01 00:00:00pages
553-556issue
6eissn
0889-2229issn
1931-8405journal_volume
35pub_type
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