Immunization with hybrid proteins containing the membrane proximal external region of HIV-1.

abstract：:The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

journal_title：AIDS research and human retroviruses

authors： Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

更新日期：1996-02-10 00:00:00

abstract：:Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

journal_title：AIDS research and human retroviruses

authors： Sampah ME,Ceccato CM,Blankson JN

更新日期：2011-02-01 00:00:00

abstract：:Mitochondrial impairment is reported in HIV-infected children receiving antiretroviral therapy (ART), as well as those naive to ART. Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In this study, we evaluate mitochondrial markers in well...

journal_title：AIDS research and human retroviruses

authors： Shen J,Liberty A,Shiau S,Strehlau R,Pierson S,Patel F,Wang L,Burke M,Violari A,Coovadia A,Abrams EJ,Arpadi S,Foca M,Kuhn L

更新日期：2020-01-01 00:00:00

abstract：:Interferon-α (IFN-α) plays a vital role in combating viral infections especially in the early control after infection. However, the HIV infection has shown substantial level of suppression of IFN-α secretion during initial phase of infection. The reasons behind this impairment are still obscure. As plasmacytoid dendri...

journal_title：AIDS research and human retroviruses

authors： Dhamanage AS,Thakar MR,Paranjape RS

更新日期：2019-01-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00

abstract：:The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that the in vitro proliferative potential of precursor cells from AIDS patients is reduced. The changes seen in bone marrow (BM) morphology and the defe...

journal_title：AIDS research and human retroviruses

authors： Isgrò A,Mezzaroma I,Aiuti A,De Vita L,Franchi F,Pandolfi F,Alario C,Ficara F,Riva E,Antonelli G,Aiuti F

更新日期：2000-10-10 00:00:00

abstract：:The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following en...

journal_title：AIDS research and human retroviruses

authors： Passam AM,Sourvinos G,Krambovitis E,Miyakis S,Stavrianeas N,Zagoreos I,Spandidos DA

更新日期：2007-08-01 00:00:00

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00

abstract：:Bacterial vaginosis (BV) has been linked to an increased risk of human immunodeficiency virus (HIV) acquisition and transmission in observational studies, but the underlying biological mechanisms are unknown. We measured biomarkers of subclinical vaginal inflammation, endogenous antimicrobial activity, and vaginal flo...

journal_title：AIDS research and human retroviruses

authors： Thurman AR,Kimble T,Herold B,Mesquita PM,Fichorova RN,Dawood HY,Fashemi T,Chandra N,Rabe L,Cunningham TD,Anderson S,Schwartz J,Doncel G

更新日期：2015-11-01 00:00:00

abstract：:Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

journal_title：AIDS research and human retroviruses

authors： Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

更新日期：2020-11-10 00:00:00

abstract：:In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of...

journal_title：AIDS research and human retroviruses

authors： D'Ettorre G,Lo Presti A,Gori C,Cella E,Bertoli A,Vullo V,Perno CF,Ciotti M,Foley BT,Ciccozzi M,HIV-2 Study Group.

更新日期：2013-09-01 00:00:00

abstract：:Epidemic modeling suggests that a major scale-up in HIV treatment could have a dramatic impact on HIV incidence. This has led both researchers and policymakers to set a goal of an "AIDS-Free Generation." One of the greatest obstacles to achieving this objective is the number of people with undiagnosed HIV infection. D...

journal_title：AIDS research and human retroviruses

authors： Burns DN,DeGruttola V,Pilcher CD,Kretzschmar M,Gordon CM,Flanagan EH,Duncombe C,Cohen MS

更新日期：2014-03-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:Human herpesvirus 6 (HHV-6), a lymphotropic herpesvirus, has been suggested as a potential cofactor in the acquired immunodeficiency syndrome (AIDS). Previous studies indicate that HHV-6 has a restricted range of susceptible species. In this study, we tested the in vitro susceptibility to HHV-6 of Macaca nemestrina (p...

journal_title：AIDS research and human retroviruses

authors： Lusso P,Secchiero P,Crowley RW

更新日期：1994-02-01 00:00:00

abstract：:A sequence of four amino acid residues amino-terminal to the only intramolecular disulphide bond of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein gp41 is recognized by an anti-idiotypic antibody (9G5A) raised against another monoclonal antibody (M38), which recognizes the C5 region of gp120. 9G...

journal_title：AIDS research and human retroviruses

authors： Lopalco L,Longhi R,Ciccomascolo F,De Rossi A,Pelagi M,Andronico F,Moore JP,Schulz T,Beretta A,Siccardi AG

更新日期：1993-01-01 00:00:00

abstract：:To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

journal_title：AIDS research and human retroviruses

authors： Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

更新日期：2021-01-24 00:00:00

abstract：:We report the results of an external quality control program, including 17 Italian centers involved in the care of patients infected by HIV, to evaluate CD4 T cell count proficiency and reproducibility. The centers received two commercial stabilized blood preparations, one with "normal" and one with "low" CD4 T cell c...

journal_title：AIDS research and human retroviruses

authors： Martini F,D'Offizi G,Girardi E,Vitale A,Cimini E,Mollicone B,Vlassi C,Aiuti F,Other Members of 2005 Italian CD4 Quality Control Network.

更新日期：2007-06-01 00:00:00

abstract：:Transmitted drug resistance (TDR) influencing nonnucleoside reverse transcriptase inhibitor (NNRTI) activity is increasing among new HIV-1 patients in several countries. As we recently observed an increase of K103N prevalence among new diagnoses in Belgium, we mined the Belgian national sequence database for homologou...

journal_title：AIDS research and human retroviruses

authors： Ruelle J,Ingels MG,Jnaoui K,Ausselet N,Vincent A,Sasse A,Verhofstede C,Goubau P

更新日期：2013-10-01 00:00:00

abstract：:The virucidal efficacy of various commercially available contact lens care cleaning regimens on human immunodeficiency virus (HIV-1) contaminated contact lenses using either cursory or meticulous cleaning with a rubber policeman was evaluated. Levels of infectious HIV-1 remaining on individual contact lenses were dete...

journal_title：AIDS research and human retroviruses

authors： Amin RM,Dean MT,Zaumetzer LE,Poiesz BJ

更新日期：1991-04-01 00:00:00

abstract：:The dichotomous effects of the protein kinase C (PKC) modulatory compounds 12-myristate 13-acetate (PMA), prostratin, and ingenol 3-angelate (I3A) on HIV-1 infection were investigated. PKC modulatory compounds were shown to be potent activators of cells latently infected with HIV-1 (I3A > prostratin). Conversely, PKC ...

journal_title：AIDS research and human retroviruses

authors： Warrilow D,Gardner J,Darnell GA,Suhrbier A,Harrich D

更新日期：2006-09-01 00:00:00

abstract：:The majority of early cases of HIV in Russia were among men who have sex with men (MSM). Despite this and the current resurgence of HIV among MSM globally, little systematic work has been done to assess current HIV risks. We conducted a rapid assessment of HIV and associated risk behaviors among MSM in Russia. An anon...

journal_title：AIDS research and human retroviruses

authors： Baral S,Sifakis F,Peryskina A,Mogilnii V,Masenior NF,Sergeyev B,Deobald I,Wirtz AL,Beyrer C

更新日期：2012-08-01 00:00:00

abstract：:A novel deletion of residue 69 of the HIV-1 reverse transcriptase (RT) gene was detected in combination with mutations V75I/V and F77L/F in a patient with partial virological response to several antiretroviral drug regimens, including stavudine (D4T), didanosine (DDI), lamivudine (3TC), saquinavir (SQV), and nevirapin...

journal_title：AIDS research and human retroviruses

authors： Suzuki K,Kaufmann GR,Mukaide M,Cunningham P,Harris C,Leas L,Kondo M,Imai M,Pett SL,Finlayson R,Zaunders J,Kelleher A,Cooper DA

更新日期：2001-09-01 00:00:00

abstract：:We investigated a strategy for gene therapy, intracellular expression of anti-HIV-1 Rev single-chain variable fragments (SFvs), in promonocytic (U1) and T (ACH-2) cell lines latently infected with HIV-1. The cellular and molecular mechanisms leading to activation of latent integrated HIV-1 provirus in U1 and ACH-2 cel...

journal_title：AIDS research and human retroviruses

authors： Ho WZ,Lai JP,Bouhamdan M,Duan L,Pomerantz RJ,Starr SE

更新日期：1998-11-20 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:An aqueous extract of Phyllanthus niruri (Euphorbiaceae) inhibited human immunodeficiency virus type-1 reverse transcriptase (HIV-1-RT). The inhibitor against HIV-1-RT in this plant was purified by combination of three column chromatographies, Sephadex LH-20, cellulose, and reverse-phase high-performance liquid chroma...

journal_title：AIDS research and human retroviruses

authors： Ogata T,Higuchi H,Mochida S,Matsumoto H,Kato A,Endo T,Kaji A,Kaji H

更新日期：1992-11-01 00:00:00

abstract：:HIV-1 CRF07_BC became prevalent in Taiwan after the epidemic among injection drug users (IDUs). We describe a unique recombinant form (URF) consisting of CRF01_AE and CRF07_BC (named URF_0107-H8) genes detected from an IDU. The 8.8 kb near full-length genome of URF_0107-H8 had a CRF01_AE backbone with two CRF07_BC fra...

journal_title：AIDS research and human retroviruses

authors： Lee NY,Wang JC,Lin YC,Wu CJ,Li CW,Li MC,Wang SW,Tseng FC,Ko WC

更新日期：2016-06-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00

abstract：:Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

journal_title：AIDS research and human retroviruses

authors： Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

更新日期：1994-01-01 00:00:00

abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

更新日期：2011-05-01 00:00:00

abstract：:Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi...

journal_title：AIDS research and human retroviruses

authors： Voisset C,Bouton O,Bedin F,Duret L,Mandrand B,Mallet F,Paranhos-Baccala G

更新日期：2000-05-20 00:00:00