Polyionic compounds selectively alter availability of CD4 receptors for HIV coat protein rgp120.

abstract：:HIV prevalence is the most commonly used measure to prioritize communities for HIV prevention. We show that data on two HIV infection stages (early vs. nonearly and late vs. nonlate) allow estimation of two better measures of prevention need: HIV incidence (for prevention of HIV acquisition) and expected probability o...

journal_title：AIDS research and human retroviruses

authors： Bärnighausen T,Tanser F,Hallett T,Newell ML

更新日期：2010-04-01 00:00:00

abstract：:Infection with human T lymphotropic virus (HTLV), although asymptomatic in most cases, can lead to severe illnesses, such as adult T cell leukemia/lymphoma or myelopathy/tropical spastic paraparesis. HTLV can be transmitted by whole-blood (WB) transfusion. The prevalence of HTLV among blood donor populations has not b...

journal_title：AIDS research and human retroviruses

authors： Pham D,Nguyen D,Nguyen TA,Tran C,Tran L,Devare S,Tran A,Bhatnagar S

更新日期：2019-04-01 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:Lectins with specificity for terminal mannose residues and anti-mannan antibodies neutralize HIV-1 infection in vitro. This is assumed to be caused by binding of the agents to the viral glycoproteins. In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cel...

journal_title：AIDS research and human retroviruses

authors： Hammar L,Hirsch I,Machado AA,De Mareuil J,Baillon JG,Bolmont C,Chermann JC

更新日期：1995-01-01 00:00:00

abstract：:GLQ223 is a formulated version of tricosanthin, a single-chain ribosome-inactivating protein that was shown in earlier studies to inhibit human immunodeficiency virus (HIV) replication in T-lymphoblastoid cells and to decrease HIV p24 levels in HIV-infected monocyte-derived macrophages as measured by flow cytometry. T...

journal_title：AIDS research and human retroviruses

authors： McGrath MS,Santulli S,Gaston I

更新日期：1990-08-01 00:00:00

abstract：:Using human macrophage hybridomas infected with HIV-1, we investigated monocyte function over a 5-week period after HIV-1 infection. Two clones, 63 and 30, were infected with HIV-1IIIB. Infection was documented by RT activity (15 x 10(6) cpm/ml), intracytoplasmic staining with an anti-p24 antibody, in situ hybridizati...

journal_title：AIDS research and human retroviruses

authors： Sperber K,Hamrang G,Louie MJ,Kalb T,Banerjee R,Choi HS,Paronetto F,Mayer L

更新日期：1993-07-01 00:00:00

abstract：:For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther...

journal_title：AIDS research and human retroviruses

authors： Overbaugh J,Anderson RJ,Ndinya-Achola JO,Kreiss JK

更新日期：1996-01-20 00:00:00

abstract：:Gag-specific immune responses and changes in HIV-1 RNA levels were evaluated in eight HIV-1-infected persons, in order to assess the immunotherapeutic potential HIV-1 p17/p24: Ty virus-like particles (p24-VLP). All treated subjects showed transient and dose-dependent proliferative responses to the Ty-VLP carrier (stim...

journal_title：AIDS research and human retroviruses

authors： Klein MR,Veenstra J,Holwerda AM,Roos MT,Gow I,Patou G,Coutinho RA,De Wolf F,Miedema F

更新日期：1997-03-20 00:00:00

abstract：:We studied 123 samples from adult chronic HIV patients initiating HAART from various centers around a newly established clinical trial site in Pretoria. Each sample was sequenced in at least one structural gene (pol, gag, and env) or functional gene (vif, vpr, and vpu). A subset of 25 samples was subjected to near ful...

journal_title：AIDS research and human retroviruses

authors： Musyoki A,Mothapo K,Rakgole J,Lukhwareni A,Bessong P,Selabe G,Bredell H,Williamson C,Mphahlele MJ

更新日期：2012-09-01 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or tricarboxylic acid cycle. The human immunodeficiency virus type 1 (HIV-1) pr...

journal_title：AIDS research and human retroviruses

authors： Hegedus A,Kavanagh Williamson M,Khan MB,Dias Zeidler J,Da Poian AT,El-Bacha T,Struys EA,Huthoff H

更新日期：2017-12-01 00:00:00

abstract：:We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

journal_title：AIDS research and human retroviruses

authors： Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

更新日期：1991-12-01 00:00:00

abstract：:The combination of didanosine (ddI) and lamivudine (3TC) is attractive considering its low cost, potency, tolerability, and convenience (once daily administration), but it is not recommended as first-line therapy for HIV infection. A prospective, multicenter, open, comparative trial was conducted in HIV-infected, anti...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Conde M,Palacios R,Sanz J,Rodríguez-Novoa S,Rivas P,Santos J,Sola J,Asensi V,de Mendoza C,Estrada V,Barreiro P,González-Lahoz J,Jiménez-Nacher I,Soriano V

更新日期：2007-10-01 00:00:00

abstract：:We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in...

journal_title：AIDS research and human retroviruses

authors： Gauduin MC,Weir R,Fung MS,Koup RA

更新日期：1998-02-10 00:00:00

abstract：:The HIV-1 reverse transcriptase genes from 37 HIV-1-positive pregnant women attending an antenatal clinical in Soweto, South Africa were sequenced and analyzed for the presence of drug resistance mutations. All women were antiretroviral drug naive, but were being screened as potential participants in clinical trials o...

journal_title：AIDS research and human retroviruses

authors： Pillay C,Bredell H,McIntyre J,Gray G,Morris L

更新日期：2002-05-20 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of metabolic and endocrine changes in HIV infection. Pentoxifylline (PTX) is able to suppress the production of TNF-alpha in vitro. The effect of two dosages of intravenously administered PTX on clinical symptoms and ex vivo LPS-stimulated TNF...

journal_title：AIDS research and human retroviruses

authors： Heijligenberg R,Romijn JA,Ackermans M,Endert E,Timmer JG,Sauerwein HP

更新日期：1998-03-01 00:00:00

abstract：:Transmission of HIV-1 and drug resistance continue to occur at a considerable level in Italy, influenced mainly by changes in modality of infection. However, the long period of infectivity makes difficult the interpretation of epidemiological networks, based on epidemiological data only. We studied 510 naive HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Lai A,Violin M,Ebranati E,Franzetti M,Micheli V,Gismondo MR,Capetti A,Meraviglia P,Simonetti FR,Bozzi G,Ciccozzi M,Galli M,Zehender G,Balotta C

更新日期：2012-08-01 00:00:00

abstract：:The extraordinarily high mutation rate of HIV suggests that the viral population exists near the threshold for viral viability. An increase in mutation could mediate a lethal increase in the already high proportion of defective viruses. We initially tested this hypothesis by culturing HIV-infected cells in mutagenic d...

journal_title：AIDS research and human retroviruses

authors： Loeb LA,Mullins JI

更新日期：2000-01-01 00:00:00

abstract：:Foamy viruses are a genus of complex retroviruses that infect a wide variety of mammals. However, a clear association with any disease process has yet to be proven for these viruses. A higher human seroprevalence was reported in African populations, perhaps due to exposure to simian foamy viruses (SFV) endemic in prim...

journal_title：AIDS research and human retroviruses

authors： Goepfert PA,Ritter GD Jr,Peng X,Gbakima AA,Zhang Y,Mulligan MJ

更新日期：1996-12-10 00:00:00

abstract：:The aim of this study was to evaluate the immunological responses induced by DNA plasmids containing HIV regulatory genes administered in combination in HIV-1-infected patients with pretreatment with highly active antiretroviral treatment (HAART). The study is a double-blind, randomized, and placebo-controlled study, ...

journal_title：AIDS research and human retroviruses

authors： Hejdeman B,Boström AC,Matsuda R,Calarota S,Lenkei R,Fredriksson EL,Sandström E,Bratt G,Wahren B

更新日期：2004-08-01 00:00:00

abstract：:Currently, complex HIV-1 recombinations among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel HIV-1 complex circulating recombinant form (CRF) consisting of B', C, and CRF01_AE (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains of th...

journal_title：AIDS research and human retroviruses

authors： Miao J,Ran J,Song Y,Liu Y,Gao L,Miao Z,Zhang C,Feng Y,Xia X

更新日期：2018-04-01 00:00:00

abstract：:The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequ...

journal_title：AIDS research and human retroviruses

authors： Cerejo P,Santos-Costa Q,Calado M,Espírito-Santo M,Parreira R,Azevedo-Pereira JM

更新日期：2018-02-01 00:00:00

abstract：:The conditioned medium of a HTLV-I-carrying T cell line HUT-102 showed cytotoxic activity against a mouse fibroblast cell line L-M. We prepared the cDNA library from HUT-102 poly(A)+ RNA and screened it using oligonucleotide probes that correspond to the amino acid sequences conserved in tumor necrosis factor (TNF) an...

journal_title：AIDS research and human retroviruses

authors： Kato S,Miki T,Takahashi N,Ohmori M,Hemmi H,Numao N,Kondo K

更新日期：1989-12-01 00:00:00

abstract：:It became evident that tenofovir DF (TDF) causes a modest and gradual decline in GFR, however, the impact of long-term use of TDF on tubular function has not been fully evaluated. In 40 patients treated with TDF and 23 patients treated with other NRTIs, urine beta(2)-microglobulin (U-BMG), percentage tubular reabsorpt...

journal_title：AIDS research and human retroviruses

authors： Kinai E,Hanabusa H

更新日期：2009-04-01 00:00:00

abstract：:We report a novel HIV-1 circulating recombinant form (CRF79_0107) from three epidemiologically unlinked patients through sexual contact in Shanxi province of China. This is the first second-generation circulating recombinant form identified in China. The breakpoint analysis of recombinants showed that CRF79_0107 was c...

journal_title：AIDS research and human retroviruses

authors： Li Y,Feng Y,Li F,Xue Z,Hu J,Xing H,Ruan Y,Shao Y

更新日期：2017-10-01 00:00:00

abstract：:The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w...

journal_title：AIDS research and human retroviruses

authors： Steuler H,Storch-Hagenlocher B,Wildemann B

更新日期：1992-01-01 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to evaluate the impact of HIV-1 very low-level viremia (<50 copies/ml) on the 2-year risk of virological failure. A retrospective analysis including HIV-positive patients presenting two consecutive HIV RNA below 50 copies/ml (outpatient clinic in Italy, first semester of 2010) was performed. ...

journal_title：AIDS research and human retroviruses

authors： Calcagno A,Motta I,Ghisetti V,Lo Re S,Allice T,Marinaro L,Milia MG,Tettoni MC,Trentini L,Orofino G,Salassa B,Di Perri G,Bonora S

更新日期：2015-10-01 00:00:00