Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs.

abstract：:We studied the heterogeneity and intactness of the vif gene in six HIV-1-infected individuals at various clinical stages. The proviral vif sequences in peripheral blood mononuclear cells were amplified by PCR, followed by cloning and sequencing of 45 vif clones. The intraindividual diversity of the vif genes ranged fr...

journal_title：AIDS research and human retroviruses

authors： Tominaga K,Kato S,Negishi M,Takano T

更新日期：1996-11-01 00:00:00

abstract：:Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

journal_title：AIDS research and human retroviruses

authors： Cox S,Margot N,Miller M,Callebaut C

更新日期：2018-05-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascer...

journal_title：AIDS research and human retroviruses

authors： Shebl FM,Engels EA,Goedert JJ

更新日期：2012-09-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:Enfuvirtide (ENF) is the first of a new class of antiretrovirals (ARVs) known as the HIV fusion inhibitors. Two phase III studies of ENF, TORO 1 and TORO 2, demonstrated that ENF given in combination with optimized background (OB) therapy significantly improved virological response, increased the time to virological f...

journal_title：AIDS research and human retroviruses

authors： Hornberger J,Kilby JM,Wintfeld N,Green J

更新日期：2006-03-01 00:00:00

abstract：:Differences in the extent of genetic diversity have been observed in human immunodeficiency virus type-1 (HIV-1) envelope sequences early in infection, and this has been linked to gender and to modifiable exogenous factors such as hormonal contraceptive use and genital tract infections. But it is unclear whether envel...

journal_title：AIDS research and human retroviruses

authors： Sagar M,Kirkegaard E,Lavreys L,Overbaugh J

更新日期：2006-05-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:The objectives of this study were to evaluate the performance of parallel rapid HIV testing and the presence of HIV-associated risk factors in pregnant women with unknown HIV status in Baja California, Mexico. Pregnant women attending the delivery unit or the prenatal clinic at Tijuana General Hospital had blood drawn...

journal_title：AIDS research and human retroviruses

authors： Viani RM,Araneta MR,Spector SA

更新日期：2013-03-01 00:00:00

abstract：:The concept that HIV causes AIDS only by directly killing CD4 cells has been questioned by a number of investigators. There has been experimental support for a number of indirect mechanisms such as apoptosis, anergy, superantigen-induced cell proliferation and depletion, defective signaling, molecular mimicry, and aut...

journal_title：AIDS research and human retroviruses

authors： Gougeon ML,Colizzi V,Dalgleish A,Montagnier L

更新日期：1993-03-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome in a subset of patients and is a primary driver of acute morbidity in...

journal_title：AIDS research and human retroviruses

authors： Al-Harthi L,Campbell E,Schneider JA,Bennett DA

更新日期：2020-08-10 00:00:00

abstract：:Phylogenetic analysis of partial env sequences of HIV-1 isolates from Cyprus and Greece suggested the existence of a distinct subtype of the virus, designated as I. We examined whether this subtype represents a distinct group, or a mosaic consisting of previously characterized subtypes. The full-length sequences under...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Magiorkinis E,Theodoridou M,Hatzakis A

更新日期：1999-05-20 00:00:00

abstract：:Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

journal_title：AIDS research and human retroviruses

authors： Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

更新日期：2014-12-01 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently exist on the status of ART drug-resistance-associated mutations (DRMs). In this stud...

journal_title：AIDS research and human retroviruses

authors： SahBandar IN,Samonte G,Telan E,Siripong N,Belcaid M,Schanzenbach D,Leano S,Chagan-Yasutan H,Hattori T,Shikuma CM,Ndhlovu LC

更新日期：2017-11-01 00:00:00

abstract：:To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

journal_title：AIDS research and human retroviruses

authors： Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

更新日期：2020-03-01 00:00:00

abstract：:Myeloid dendritic cells (mDCs) are essential for initiation of adaptive immune responses but are depleted in HIV infection. Evidence suggests that apoptosis mediates loss, and to further understand the pathways involved, expression of caspases mediating apoptosis via the extrinsic and intrinsic pathways was analyzed. ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Benlahrech A,Kelleher P,Patterson S

更新日期：2013-04-01 00:00:00

abstract：:In HIV-infected persons, certain HLA class I alleles are associated with effective control of viremia, while others are associated with rapid disease progression. Among the most divergent clinical outcomes are the relatively good prognosis in HLA-B*5801 expressing persons and poor prognosis with HLA-B*5802. These two ...

journal_title：AIDS research and human retroviruses

authors： Ngumbela KC,Day CL,Mncube Z,Nair K,Ramduth D,Thobakgale C,Moodley E,Reddy S,de Pierres C,Mkhwanazi N,Bishop K,van der Stok M,Ismail N,Honeyborne I,Crawford H,Kavanagh DG,Rousseau C,Nickle D,Mullins J,Heckerman D,K

更新日期：2008-01-01 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

journal_title：AIDS research and human retroviruses

authors： Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

更新日期：1990-07-01 00:00:00

abstract：:The human foamy virus (HFV) is a complex retrovirus that contains several regulatory and auxiliary bel genes besides the gag, pol, and env genes. In contrast to the gene products of bel 1 and bel 2/bet that were identified previously, the Bel 3 protein has not been described to date. Here we report the identification ...

journal_title：AIDS research and human retroviruses

authors： Weissenberger J,Flügel RM

更新日期：1994-05-01 00:00:00

abstract：:Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex...

journal_title：AIDS research and human retroviruses

authors： Pauza CD,Horejsh D,Wallace M

更新日期：1998-04-01 00:00:00

abstract：:All-trans-retinoic acid (RA) has been shown either to activate or repress human immunodeficiency virus type 1 (HIV-1) replication in primary monocyte-derived-macrophages (MDMs). We systematically investigated the contribution that cell donor and virus differences make to this variability. We found that the effect of R...

journal_title：AIDS research and human retroviruses

authors： Brown XQ,Hanley TM,Viglianti GA

更新日期：2002-06-10 00:00:00

abstract：:Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic resistance test (GRT) is not routinely performed in many centers. The aim of this study is to evaluate the prevalence of InSTI-related mutations in our large cohort. We examined all integrase GRTs performed as part of routine clin...

journal_title：AIDS research and human retroviruses

authors： De Francesco MA,Izzo I,Properzi M,Gargiulo F,Caccuri F,Quiros-Roldan E,Castelli F,Caruso A,Focà E

更新日期：2018-07-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00

abstract：:HIV-1 subtype C is the prevalent subtype in South Africa, with non-C subtypes being sporadically detected. The accessory genes of subtype C have not been well studied in South Africa. In this study the HIV-1 vpr region of 58 strains was amplified, sequenced, and subtyped. Phylogenetic analysis characterized 54 strains...

journal_title：AIDS research and human retroviruses

authors： Romani B,Glashoff R,Engelbrecht S

更新日期：2009-03-01 00:00:00

abstract：:We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE linea...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

更新日期：2013-12-01 00:00:00

abstract：:To investigate HIV-1-related B cell disorders, the quantity of CD27 positive (CD27+) B cells and their CD38, CD95, and bcl-2 intensities were examined by flow cytometry analysis in 16 drug-naive patients, 27 highly active antiretroviral therapy (HAART)-treated patients, and 20 uninfected controls. CD27+ B cells have b...

journal_title：AIDS research and human retroviruses

authors： Chong Y,Ikematsu H,Kikuchi K,Yamamoto M,Murata M,Nishimura M,Nabeshima S,Kashiwagi S,Hayashi J

更新日期：2004-02-01 00:00:00

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00