Lectin-mediated effects on HIV type 1 infection in vitro.

abstract：:The structure of the Vpu protein of human immunodeficiency virus type 1 (HIV-1) is composed of a short Nterminal domain (NTD), a transmembrane domain (TM), and a cytoplasmic domain (CD). Previous studies have shown that the Vpu protein from subtype B HIV-1 is transported predominantly to the rough endoplasmic reticulu...

journal_title：AIDS research and human retroviruses

authors： Pacyniak E,Gomez ML,Gomez LM,Mulcahy ER,Jackson M,Hout DR,Wisdom BJ,Stephens EB

更新日期：2005-05-01 00:00:00

abstract：:The proportion of human immunodeficiency virus type 1 (HIV-1) among Vietnamese injecting drug users (IDUs) in Melbourne, Australia exceeds that of the background population. To investigate the molecular epidemiology of HIV-1 among this group, the C2-V4 region of the HIV-1 envelope was directly sequenced from 11 Vietna...

journal_title：AIDS research and human retroviruses

authors： Ryan CE,Elliott JH,Middleton T,Mijch AM,Street AC,Hellard M,Crofts N,Crowe SM,Oelrichs RB

更新日期：2004-12-01 00:00:00

abstract：:In order to further characterize the interaction of human immunodeficiency viruses (HIV) with the CD4 receptor at the molecular level, a binding test was performed using iodine-labeled glycoproteins, 125I-gp160 from HIV-1 and 125I-gp140 from HIV-2, to bind to lymphoid cells expressing the CD4 receptor. The inhibition ...

journal_title：AIDS research and human retroviruses

authors： Bahraoui E,Benjouad A,Guetard D,Kolbe H,Gluckman JC,Montagnier L

更新日期：1992-05-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00

abstract：:HIV-1 is classified into three groups, M (major), N (non-M non-O), and O (outlier); each group arose from a separate transmission of SIVcpz into humans. HIV-1 group N was recently discovered and infections with this virus are rare with only eight documented cases. All group N infections have been found in Cameroon and...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Coffey R,Vallari A,Ngansop C,Mbanya D,Ndembi N,Kaptué L,Gürtler LG,Bodelle P,Schochetman G,Devare SG,Brennan CA

更新日期：2006-01-01 00:00:00

abstract：:The development of HIV vaccines is an urgent priority and there is need to generate reagents representing multiple subtypes that can be used to screen HIV-1-specific responses. We used Aldrithiol-2 (AT-2), a mild oxidizing reagent, to eliminate the infectivity of HIV while maintaining its structure and ability to be p...

journal_title：AIDS research and human retroviruses

authors： Rutebemberwa A,Bess JW Jr,Brown B,Arroyo M,Eller M,Slike B,Polonis V,McCutchan F,Currier JR,Birx D,Robb M,Marovich M,Lifson JD,Cox JH

更新日期：2007-04-01 00:00:00

abstract：:In a polygamous marriage in Senegal, the husband and his two spouses were infected with HIV-1 group O. This study provides new full-length genome sequences for the two spouses (99SE-MP1299 and 99SE-MP1300) and the 3'-end LTR-tat fragment (6084 bp) for the husband (98SE-42HALD). Phylogenetic tree and diversity plot ana...

journal_title：AIDS research and human retroviruses

authors： Kane CT,Montavon C,Toure MA,Faye MA,Ndiaye AG,Diallo AG,Ndoye I,Liegeois F,Delaporte E,Mboup S,Peeters M

更新日期：2001-08-10 00:00:00

abstract：:Persons living with HIV (PLWH) with substance use disorders (SUD) remain a population difficult to engage in HIV care. Project HOPE (Hospital Visits as an Opportunity for Prevention and Engagement), a randomized controlled trial testing patient navigation with/without contingency management for PLWH with SUD, aimed to...

journal_title：AIDS research and human retroviruses

authors： Summers NA,Colasanti JA,Feaster DJ,Armstrong WS,Rodriguez A,Jain MK,Jacobs P,Metsch LR,Del Rio C

更新日期：2020-05-01 00:00:00

abstract：:The presence of transmitted drug-resistant HIV-1 (TDR) at the time of antiretroviral therapy (ART) initiation is associated with failure to achieve viral load suppression. Rates of TDR in ART-naive patients have been reported from various parts of the world through ongoing national, regional, and global evaluations; h...

journal_title：AIDS research and human retroviruses

authors： MacVeigh MS,Kosmetatos MK,McDonald JE,Reeder JL,Parrish DA,Young TP

更新日期：2013-02-01 00:00:00

abstract：:A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses and antibodies in nonhuman primates. In this rando...

journal_title：AIDS research and human retroviruses

authors： Mehendale S,van Lunzen J,Clumeck N,Rockstroh J,Vets E,Johnson PR,Anklesaria P,Barin B,Boaz M,Kochhar S,Lehrman J,Schmidt C,Peeters M,Schwarze-Zander C,Kabamba K,Glaunsinger T,Sahay S,Thakar M,Paranjape R,Gilmour J,

更新日期：2008-06-01 00:00:00

abstract：:The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag...

journal_title：AIDS research and human retroviruses

authors： Seddiki N,Ben Younes-Chennoufi A,Benjouad A,Saffar L,Baumann N,Gluckman JC,Gattegno L

更新日期：1996-05-20 00:00:00

abstract：:The capacity to neutralize the human immunodeficiency virus (HIV) in vitro was examined in 52 sera obtained from 23 seropositive individuals in addition to 7 negative control sera. Neutralization was measured as the activity of a serum to protect MT-4 cells against the cytopathic effect of HTLV-IIIB. Virus neutralizat...

journal_title：AIDS research and human retroviruses

authors： Wendler I,Bienzle U,Hunsmann G

更新日期：1987-07-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:It is known that transmitted drug resistance (TDR) will most likely emerge in regions where antiretroviral therapy (ART) has been widely available for years. However, after a decade of rapid scale-up of ART in China, there are few data regarding TDR among HIV-infected patients prior to initiating first-line ART in Chi...

journal_title：AIDS research and human retroviruses

authors： Wang X,He C,Xing H,Liao L,Xu X,He J,Liu Y,Ling H,Liang S,Hsi JH,Ruan Y,Shao Y

更新日期：2012-12-01 00:00:00

abstract：:The present study investigated the immunological pathogenesis of immune reconstitution inflammatory syndrome (IRIS) in acquired immunodeficiency syndrome (AIDS) patients undergoing highly active antiretroviral therapy (HAART). A total of 238 patients with AIDS who received initial HAART were included in this prospecti...

journal_title：AIDS research and human retroviruses

authors： Zheng Y,Zhou H,He Y,Chen Z,He B,He M

更新日期：2014-12-01 00:00:00

abstract：:In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the c...

journal_title：AIDS research and human retroviruses

authors： Dong XN,Chen X,Chen Y,Ablimit A,Ye Z,Wu Y,Chen YH

更新日期：2005-03-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:Previous studies have shown that coinfection of the human T lymphotrophic virus type I (HTLV-I) chronically infected cell line MT4 with human immunodeficiency virus type 1 (HIV-1) results in cells which spontaneously activate complement via the classical pathway. This complement activation was antibody independent, ye...

journal_title：AIDS research and human retroviruses

authors： Spear GT,Jiang HX,Sullivan BL,Gewurz H,Landay AL,Lint TF

更新日期：1991-07-01 00:00:00

abstract：:Although suppression of HIV-1 RNA below the limit of detection is associated with optimal outcomes, many patients can maintain or increase their CD4(+) count for prolonged time periods in the presence of persistent low-level viremia. We followed seven patients with prolonged (>5 years) discordant CD4(+)/viral load (VL...

journal_title：AIDS research and human retroviruses

authors： Kaplan SS,Ferrari G,Wrin T,Hellmann NS,Tomaras GD,Gryszowka VE,Fiscus SA,Weinhold KJ,Hicks CB

更新日期：2005-01-01 00:00:00

abstract：:Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). The polymerase chain reaction (PCR) was used to amplify the env gp41, rev, and nef overlapping coding sequences from provirus present in the blood of both animals at 1, 6, and 15 months po...

journal_title：AIDS research and human retroviruses

authors： Slade A,Jones S,Almond N,Kitchin P

更新日期：1993-02-01 00:00:00

abstract：:This retrospective and longitudinal study evaluated the long-term hepatic tolerance of a nelfinavir (NFV)-antiretroviral combined regimen in 82 patients of the HCV-HIV Cohort of CISIH-Sud of Marseilles. Follow-up data (liver enzyme levels, CD4 cell count, HIV viral load, and metabolic parameters) of patients treated w...

journal_title：AIDS research and human retroviruses

authors： Poizot-Martin I,Marimoutou C,Drogoul-Vey MP,Vion-Dury F,Frixon-Marin V,Benhaim S,Poggi P,Gastaut JA

更新日期：2005-10-01 00:00:00

abstract：:A molecular epidemiologic study of HIV-1 in Greenland showed distinct transmission clusters correlated with demographic and behavioral data. Resistance mutations were found in a majority of the pol sequences. The objective of the present study was to estimate prevalence of drug resistance in Greenland and identify tra...

journal_title：AIDS research and human retroviruses

authors： Madsen TV,Lohse N,Jensen ES,Obel N,Ladefoged K,Gerstoft J,Petersen AB,Nielsen C,Jørgensen LB

更新日期：2008-08-01 00:00:00

abstract：:Simian AIDS-related lymphomas (sARL) of cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied in relation to growth in severe combined immunodeficient (SCID) mice, karyotype abnormalities, and DNA sequence of the first noncoding region of the Bcl-6 gene. The tumors were diffuse large B ...

journal_title：AIDS research and human retroviruses

authors： Castaños-Vélez E,Heiden T,Lindvall C,Capello D,Sandlund A,Imreh S,Blennow E,Andersson LC,Gaidano G,Nordenskjöld M,Biberfeld P

更新日期：2002-03-20 00:00:00

abstract：:An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branche...

journal_title：AIDS research and human retroviruses

authors： Roques P,Menu E,Narwa R,Scarlatti G,Tresoldi E,Damond F,Mauclère P,Dormont D,Chaouat G,Simon F,Barré-Sinoussi F

更新日期：1999-11-20 00:00:00

abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

journal_title：AIDS research and human retroviruses

authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

更新日期：1995-05-01 00:00:00

abstract：:CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

journal_title：AIDS research and human retroviruses

authors： Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Many human immunodeficiency virus (HIV) proteins including Tat are produced by HIV-infected astrocytes and secreted into the brain resulting in extensive neuronal damage that contributes to the pathogenesis of HIV dementia. The neuroprotective hormone 17beta-estradiol (E2) is known to negatively regulate the HIV trans...

journal_title：AIDS research and human retroviruses

authors： Heron PM,Turchan-Cholewo J,Bruce-Keller AJ,Wilson ME

更新日期：2009-11-01 00:00:00

abstract：:This prospective, open-label, multicenter trial evaluated the effects of once-weekly (qw) epoetin alfa on quality of life (QOL) and hemoglobin (Hb) levels in anemic human immunodeficiency virus (HIV)-infected adult receiving antiretroviral therapy. A total of 650 patients with Hb < or = 11 g/dl received epoetin alfa 4...

journal_title：AIDS research and human retroviruses

authors： Saag MS,Bowers P,Leitz GJ,Levine AM,Community HIV Anemia Management Protocol Sites (CHAMPS) Study Group.

更新日期：2004-10-01 00:00:00