Short communication: HIV type 1 phenotype, tropism, and sequence patterns: association and preference.

Abstract:

:In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the capability of HIV-1 to use coreceptor CXCR4, but not CCR5. Moreover, compared to NSI or R5 isolates, SI or X4 HIV-1 isolates significantly prefer higher net charges and the loss of the N-linked glycosylation site in the V3 loop, but they show no preference in either net charge or N-linked glycosylation of the V1V2 region. In addition, no significant relationship between V1V2 length and virus tropism or phenotypes was observed.

authors

Dong XN,Chen X,Chen Y,Ablimit A,Ye Z,Wu Y,Chen YH

doi

10.1089/aid.2005.21.234

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

234-8

issue

3

eissn

0889-2229

issn

1931-8405

journal_volume

21

pub_type

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