Simian AIDS-related lymphoma growth in severe combined immunodeficiency mice is independent of karyotypic abnormalities or Bcl-6 mutations.

abstract：:Even in the setting of maximally suppressive antiretroviral therapy (ART), HIV persists indefinitely. Several mechanisms might contribute to this persistence, including chronic inflammation and immune dysfunction. In this study, we have explored a preclinical model for the evaluation of potential interventions that mi...

journal_title：AIDS research and human retroviruses

authors： Dunham RM,Gordon SN,Vaccari M,Piatak M,Huang Y,Deeks SG,Lifson J,Franchini G,McCune JM

更新日期：2013-02-01 00:00:00

abstract：:Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in o...

journal_title：AIDS research and human retroviruses

authors： Archin NM,Espeseth A,Parker D,Cheema M,Hazuda D,Margolis DM

更新日期：2009-02-01 00:00:00

abstract：:Gag-specific immune responses and changes in HIV-1 RNA levels were evaluated in eight HIV-1-infected persons, in order to assess the immunotherapeutic potential HIV-1 p17/p24: Ty virus-like particles (p24-VLP). All treated subjects showed transient and dose-dependent proliferative responses to the Ty-VLP carrier (stim...

journal_title：AIDS research and human retroviruses

authors： Klein MR,Veenstra J,Holwerda AM,Roos MT,Gow I,Patou G,Coutinho RA,De Wolf F,Miedema F

更新日期：1997-03-20 00:00:00

abstract：:HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. T...

journal_title：AIDS research and human retroviruses

authors： He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

更新日期：2011-10-01 00:00:00

abstract：:We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in...

journal_title：AIDS research and human retroviruses

authors： Gauduin MC,Weir R,Fung MS,Koup RA

更新日期：1998-02-10 00:00:00

abstract：:Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

journal_title：AIDS research and human retroviruses

authors： Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

更新日期：2020-11-10 00:00:00

abstract：:Before the introduction of HAART, HIV-associated neurocognitive impairment (NCI) was recognized as an independent risk factor for death. Since 1996, we conducted a prospective study to assess whether NCI still represents a negative prognostic factor for mortality. Patients were administered measures of neurocognitive ...

journal_title：AIDS research and human retroviruses

authors： Tozzi V,Balestra P,Serraino D,Bellagamba R,Corpolongo A,Piselli P,Lorenzini P,Visco-Comandini U,Vlassi C,Quartuccio ME,Giulianelli M,Noto P,Galgani S,Ippolito G,Antinori A,Narciso P

更新日期：2005-08-01 00:00:00

abstract：:Infection with drug-resistant human immunodeficiency virus type 1 (HIV-1) has been documented in all countries that have surveyed for it and may result in an unfavorable response to therapy. The prevalence and characteristics of individuals with transmitted resistance to antiretroviral drugs have been scarcely describ...

journal_title：AIDS research and human retroviruses

authors： Sprinz E,Netto EM,Patelli M,Lima JS,Furtado JJ,da Eira M,Zajdenverg R,Madruga JV,Lewi DS,Machado AA,Pedro RJ,Soares MA

更新日期：2009-09-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) probably originate from ancient germ cell infections by exogenous retroviruses. A high expression of retroviruses in reproductive tissue increases the risk of viral transmission to germ line cells. We therefore investigated the expression of human ERVs (HERVs) in normal endometrium, endo...

journal_title：AIDS research and human retroviruses

authors： Hu L,Hornung D,Kurek R,Ostman H,Blomberg J,Bergqvist A

更新日期：2006-06-01 00:00:00

abstract：:We identified an HIV-1 variant that belongs to the M group, with limited similarity of short genetic regions (100-200 nt) to subtype K, but the remainder of the genome is unrelated to any established HIV-1 subtype. The isolate was obtained from an HIV-1-positive male, living in the Netherlands, who encountered the vir...

journal_title：AIDS research and human retroviruses

authors： van der Hoek L,Pollakis G,Lukashov VV,Jebbink MF,Jeeninga RE,Bakker M,Dukers N,Jurriaans S,Paxton WA,Back NK,Berkhout B

更新日期：2007-03-01 00:00:00

abstract：:Transmitted drug resistance (TDR) influencing nonnucleoside reverse transcriptase inhibitor (NNRTI) activity is increasing among new HIV-1 patients in several countries. As we recently observed an increase of K103N prevalence among new diagnoses in Belgium, we mined the Belgian national sequence database for homologou...

journal_title：AIDS research and human retroviruses

authors： Ruelle J,Ingels MG,Jnaoui K,Ausselet N,Vincent A,Sasse A,Verhofstede C,Goubau P

更新日期：2013-10-01 00:00:00

abstract：:We studied 123 samples from adult chronic HIV patients initiating HAART from various centers around a newly established clinical trial site in Pretoria. Each sample was sequenced in at least one structural gene (pol, gag, and env) or functional gene (vif, vpr, and vpu). A subset of 25 samples was subjected to near ful...

journal_title：AIDS research and human retroviruses

authors： Musyoki A,Mothapo K,Rakgole J,Lukhwareni A,Bessong P,Selabe G,Bredell H,Williamson C,Mphahlele MJ

更新日期：2012-09-01 00:00:00

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris L

更新日期：2005-01-01 00:00:00

abstract：:We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. ...

journal_title：AIDS research and human retroviruses

authors： Schwartz D,Sharma U,Busch M,Weinhold K,Matthews T,Lieberman J,Birx D,Farzedagen H,Margolick J,Quinn T

更新日期：1994-12-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:To provide a better understanding of the role of placenta in vertical human immunodeficiency virus (HIV) transmission, we have studied the infection of placental trophoblast in a group of 15 mother-neonate pairs. By nested PCR amplification of the C2V3 env gene region, HIV-1 has been found to infect the placenta in fi...

journal_title：AIDS research and human retroviruses

authors： Zachar V,Zacharova V,Fink T,Thomas RA,King BR,Ebbesen P,Jones TB,Goustin AS

更新日期：1999-12-10 00:00:00

abstract：:To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

journal_title：AIDS research and human retroviruses

authors： Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

更新日期：2020-03-01 00:00:00

abstract：:Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1...

journal_title：AIDS research and human retroviruses

authors： Cheedarla N,Sundaramurthi JC,Hemalatha B,Anangi B,Nesakumar M,Ashokkumar M,Vidya Vijayan KK,Tripathy SP,Swaminathan S,Vaniambadi SK,Ramanathan DV,Hanna LE

更新日期：2019-02-01 00:00:00

abstract：:The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequ...

journal_title：AIDS research and human retroviruses

authors： Cerejo P,Santos-Costa Q,Calado M,Espírito-Santo M,Parreira R,Azevedo-Pereira JM

更新日期：2018-02-01 00:00:00

abstract：:Multiple drug effect analyses with mismatched double-stranded RNA (mismatched dsRNA or Ampligen) as a core drug were performed to identify other agents and mechanisms through which mismatched dsRNA may potentiate effective therapeutic intervention in human immunodeficiency virus (HIV) infection. Antiviral activities w...

journal_title：AIDS research and human retroviruses

authors： Montefiori DC,Robinson WE Jr,Mitchell WM

更新日期：1989-04-01 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

journal_title：AIDS research and human retroviruses

authors： Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

更新日期：2020-03-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Mucosal candidiasis is a common complication of HIV infection and HIV-positive women may develop both oropharyngeal and vaginal disease. Colonization with Candida albicans and related species at either site is a common preceding event in asymptomatic women. To examine the molecular epidemiology of colonizing yeast str...

journal_title：AIDS research and human retroviruses

authors： Dahl KM,Keath EJ,Fraser VJ,Powderly WG

更新日期：1997-04-10 00:00:00

abstract：:Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). The polymerase chain reaction (PCR) was used to amplify the env gp41, rev, and nef overlapping coding sequences from provirus present in the blood of both animals at 1, 6, and 15 months po...

journal_title：AIDS research and human retroviruses

authors： Slade A,Jones S,Almond N,Kitchin P

更新日期：1993-02-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:We examined baseline HIV-1 protease and reverse transcriptase sequences and HIV clinical parameters from 1,021 consecutive patients (814 male, 207 female) through the Royal Perth Hospital HIV service to investigate HIV-1 subtype diversity and local phylogenetic networks from 2000 to 2014. HIV-1 subtype B virus sequenc...

journal_title：AIDS research and human retroviruses

authors： Castley AS,Gaudieri S,James I,Gizzarelli LS,Guelfi G,John M,Nolan D

更新日期：2016-03-01 00:00:00

abstract：:Peripheral blood mononuclear cell (PBMC) cultures were established from patients with antibody to human immunodeficiency virus (HIV). Asymptomatically infected patients [5 of 19] had significant lymphocyte transformation responses induced in culture by a purified, recombinant envelope glycoprotein (rgp120) from the vi...

journal_title：AIDS research and human retroviruses

authors： Torseth JW,Berman PW,Merigan TC

更新日期：1988-02-01 00:00:00

abstract：:Foamy viruses are a genus of complex retroviruses that infect a wide variety of mammals. However, a clear association with any disease process has yet to be proven for these viruses. A higher human seroprevalence was reported in African populations, perhaps due to exposure to simian foamy viruses (SFV) endemic in prim...

journal_title：AIDS research and human retroviruses

authors： Goepfert PA,Ritter GD Jr,Peng X,Gbakima AA,Zhang Y,Mulligan MJ

更新日期：1996-12-10 00:00:00