In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome.

abstract：:SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization during acute infection, but little is understood about diversity and...

journal_title：AIDS research and human retroviruses

authors： Reeve AB,Pearce NC,Patel K,Augustus KV,Novembre FJ

更新日期：2010-06-01 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4+ memory T cells. Polymorphisms in CCR5 regulate CCR5 expression, which, in turn, influences HIV...

journal_title：AIDS research and human retroviruses

authors： Mehlotra RK

更新日期：2020-10-01 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci...

journal_title：AIDS research and human retroviruses

authors： Müller-Trutwin MC,Corbet S,Hansen J,Georges-Courbot MC,Diop O,Rigoulet J,Barré-Sinoussi F,Fomsgaard A

更新日期：1999-07-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:We characterized two immune escape viruses (SHIV(KU-1/105w52) and SHIV(KU-1/105w98)) from a macaque immunized with DeltavpuDeltanef SHIV-4 and challenged with pathogenic SHIV(KU-1). This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses c...

journal_title：AIDS research and human retroviruses

authors： Stipp HL,Kumar A,Narayan O

更新日期：2000-10-10 00:00:00

abstract：:Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

journal_title：AIDS research and human retroviruses

authors： Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

更新日期：2014-12-01 00:00:00

abstract：:HIV-infected individuals are at high risk of developing atherosclerosis and cardiovascular disease, in part, due to HIV-induced impairment of cholesterol metabolism. In vitro studies demonstrated that HIV-1 protein Nef inhibits activity of ABCA1, the main cellular cholesterol transporter, leading to cholesterol accumu...

journal_title：AIDS research and human retroviruses

authors： Pushkarsky T,Shilov E,Kruglova N,Naumann R,Brichacek B,Jennelle L,Sviridov D,Kruglov A,Nedospasov SA,Bukrinsky M

更新日期：2017-01-01 00:00:00

abstract：:The human immunodeficiency virus 1 envelope glycoprotein is synthesized as a precursor, gp160, which is subsequently cleaved to generate the external gp120 and the transmembrane gp41. Both of these cleavage products are known to mediate critical functions of the virus. In order to define the best strategy for the deve...

journal_title：AIDS research and human retroviruses

authors： Pasquali JL,Kieny MP,Kolbe H,Christmann D,Knapp AM

更新日期：1990-09-01 00:00:00

abstract：:This study reports on the drug resistance profiles for HIV-infected pediatrics in Jamaica who have been exposed to antiretroviral therapy (ART). The genetic diversity of HIV-1 found in these patients was also determined using phylogenetic analysis. The protease-reverse transcriptase (Pro-RT) region of the genome was a...

journal_title：AIDS research and human retroviruses

authors： Ramkissoon AP,Amarakoon II,Hamilton CL,Pierre RB,Eyzaguirre LM,Carr JK,Blattner WA,Roye ME

更新日期：2015-09-01 00:00:00

abstract：:Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

journal_title：AIDS research and human retroviruses

authors： Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

更新日期：1994-01-01 00:00:00

abstract：:The expression of HLA class I antigens is downregulated in CD4+ T cells following in vitro HIV-1 infection. We determined whether the expression of HLA class I antigens is downmodulated in peripheral blood lymphocytes (PBLs) of HIV-1-positive subjects and whether this defect correlates with disease progression. A coho...

journal_title：AIDS research and human retroviruses

authors： Puppo F,Brenci S,Bosco O,Lanza L,Barocci S,Nocera A,Ghio M,Contini P,Setti M,Scudeletti M,Indiveri F

更新日期：1997-11-20 00:00:00

abstract：:Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w...

journal_title：AIDS research and human retroviruses

authors： Liska V,Fultz PN,Su L,Ruprecht RM

更新日期：1997-09-01 00:00:00

abstract：:Epidemiological studies strongly suggest that a newly discovered herpesvirus, Kaposi's sarcoma associated-herpesvirus (KSHV/HHV8), is the likely infectious cause of Kaposi's sarcoma (KS). Identification of this agent suggests the possibility that existing anti-herpesvirus chemotherapeutics have activity against KSHV. ...

journal_title：AIDS research and human retroviruses

authors： Flore O,Gao SJ

更新日期：1997-09-20 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:It has been proposed that HIV-1-neutralizing 2F5 and 4E10 monoclonal antibodies recognize gp41 ectodomain pretransmembrane sequences in the context of the membrane interface. With the aim of evaluating lipid-bilayer surface effects on recognition, we use phospholipid model systems to investigate the ability of 2F5 and...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Martínez S,Lorizate M,Katinger H,Kunert R,Nieva JL

更新日期：2006-10-01 00:00:00

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:During a 6-month period, we studied the diversity of HIV-1 subtypes in 392 adult patients seen in Bichat-Claude Bernard Hospital, northern Paris, France. All the samples were serotyped and a subset was genotyped by means of HMA. Serotyping was performed with a new peptide subtype-specific EIA (SSEIA), based on in vitr...

journal_title：AIDS research and human retroviruses

authors： Simon F,Loussert-Ajaka I,Damond F,Saragosti S,Barin F,Brun-Vézinet F

更新日期：1996-10-10 00:00:00

abstract：:HIV-1 subtype B isolates have previously been described in India only in the state of Andhra Pradesh, while subtype C isolates have been reported as widespread in the Bombay and Goa regions of India. Gag subtype was determined in HIV-1 isolates from six Indians and one Ethiopian. One Indian was a native of Goa resid...

journal_title：AIDS research and human retroviruses

authors： Voevodin A,Crandall KA,Seth P,al Mufti S

更新日期：1996-05-01 00:00:00

abstract：:The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following en...

journal_title：AIDS research and human retroviruses

authors： Passam AM,Sourvinos G,Krambovitis E,Miyakis S,Stavrianeas N,Zagoreos I,Spandidos DA

更新日期：2007-08-01 00:00:00

abstract：:Propensity for developing coronary heart disease (CHD) is linked with Framingham-defined cardiovascular risk factors and elevated inflammatory biomarkers. Cardiovascular risk and inflammatory biomarkers were evaluated in ARIES, a Phase IIIb/IV clinical trial in which 515 antiretroviral-naive HIV-infected subjects init...

journal_title：AIDS research and human retroviruses

authors： Young B,Squires KE,Ross LL,Santiago L,Sloan LM,Zhao HH,Wine BC,Pakes GE,Margolis DA,Shaefer MS,Aries EPZ108859 Study Team.

更新日期：2013-02-01 00:00:00

abstract：:Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye termin...

journal_title：AIDS research and human retroviruses

authors： Guimarães PM,Ferreira JL,Coelho LP,Cavalcanti Jde S,Lopes GI,Matsuda EM,Almeida FJ,Almeida VC,Campeas AE,Junior LC,Brígido LF,Sa˜o Paulo Salvage Workgroup.

更新日期：2015-12-01 00:00:00

abstract：:Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

journal_title：AIDS research and human retroviruses

authors： Staats HF,Montgomery SP,Palker TJ

更新日期：1997-07-20 00:00:00

abstract：:Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex...

journal_title：AIDS research and human retroviruses

authors： Pauza CD,Horejsh D,Wallace M

更新日期：1998-04-01 00:00:00

abstract：:Despite the availability of antiretroviral therapy (ART), HIV-infected drug users, particularly crack cocaine users, continue to have high HIV-related morbidity and mortality. We conducted a cross-sectional analysis of the baseline data for hospitalized HIV-infected crack cocaine users recruited for Project HOPE (Hosp...

journal_title：AIDS research and human retroviruses

authors： Doshi RK,Vogenthaler NS,Lewis S,Rodriguez A,Metsch L,del Rio C

更新日期：2012-09-01 00:00:00

abstract：:We identified an HIV-1 variant that belongs to the M group, with limited similarity of short genetic regions (100-200 nt) to subtype K, but the remainder of the genome is unrelated to any established HIV-1 subtype. The isolate was obtained from an HIV-1-positive male, living in the Netherlands, who encountered the vir...

journal_title：AIDS research and human retroviruses

authors： van der Hoek L,Pollakis G,Lukashov VV,Jebbink MF,Jeeninga RE,Bakker M,Dukers N,Jurriaans S,Paxton WA,Back NK,Berkhout B

更新日期：2007-03-01 00:00:00

abstract：:Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects wi...

journal_title：AIDS research and human retroviruses

authors： Thakar MR,Patke D,Lakhashe SK,Bhonge L,Kulkarni SV,Tripathy SP,Gupte N,Brookmeyer R,Quinn TC,Paranjape RS,Bollinger RC

更新日期：2002-12-10 00:00:00

abstract：:Currently, complex HIV-1 recombinations among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel HIV-1 complex circulating recombinant form (CRF) consisting of B', C, and CRF01_AE (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains of th...

journal_title：AIDS research and human retroviruses

authors： Miao J,Ran J,Song Y,Liu Y,Gao L,Miao Z,Zhang C,Feng Y,Xia X

更新日期：2018-04-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

journal_title：AIDS research and human retroviruses

authors： Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

更新日期：1996-02-10 00:00:00