Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor.

abstract：:Replacing the Pseudomonas exotoxin A (PE) cell binding domain with the human immunodeficiency virus (HIV) gp120 binding domain from CD4 yields a hybrid toxin (CD4-PE) with potential therapeutic use in treating acquired immunodeficiency syndrome (AIDS). To find the most therapeutically potent combination of CD4 and PE ...

journal_title：AIDS research and human retroviruses

authors： Winkler G,Jakubowski A,Turner S,Liu T,Burrus B,McGray P,Heanue T,Rosa M,Griffiths BA,Wali A

更新日期：1991-04-01 00:00:00

abstract：:Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha). To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF...

journal_title：AIDS research and human retroviruses

authors： Harakeh S,Jariwalla RJ

更新日期：1997-02-10 00:00:00

abstract：:We previously reported mother-to-child transmission of HIV-1 in nine (6.7%) of 135 children on nevirapine prophylaxis in Vietnam. In the current study, we investigated the appearance and profile of antiretroviral drug (ARV) resistance mutations, the predicted coreceptor usage, and the genetic diversity of HIV-1 strain...

journal_title：AIDS research and human retroviruses

authors： Phan CT,Pham HV,Bi X,Ishizaki A,Saina M,Phung CD,Khu DT,Ichimura H

更新日期：2015-08-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is essential for virus entry and the formation of multinucleated giant cells by cell fusion, one of the major virus-induced cytopathic effects. To study the effects of potential fusion inhibitors, a vaccinia virus recombinant expressing the envelope...

journal_title：AIDS research and human retroviruses

authors： Owens RJ,Tanner CC,Mulligan MJ,Srinivas RV,Compans RW

更新日期：1990-11-01 00:00:00

abstract：:African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci...

journal_title：AIDS research and human retroviruses

authors： Müller-Trutwin MC,Corbet S,Hansen J,Georges-Courbot MC,Diop O,Rigoulet J,Barré-Sinoussi F,Fomsgaard A

更新日期：1999-07-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B...

journal_title：AIDS research and human retroviruses

authors： Koopman G,Haaksma AG,ten Velden J,Hack CE,Heeney JL

更新日期：1999-03-01 00:00:00

abstract：:An observational, prospective, longitudinal cohort study was performed at the AIDS Clinic of a tertiary care institution in Mexico City to determine the association of viral load (VL) and CD4+ lymphocyte kinetics with the development of oral candidosis (OC) and hairy leukoplakia (HL). Participants were HIV-infected ad...

journal_title：AIDS research and human retroviruses

authors： Ramírez-Amador V,Ponce-De-León S,Sierra-Madero J,Soto-Ramírez L,Esquivel-Pedraza L,Anaya-Saavedra G

更新日期：2005-12-01 00:00:00

abstract：:We have characterized human foamy virus (HFV) proviral DNA and determined HFV expression in a persistent infection model, the Dami megakaryocytic cell line. Molecular studies were performed on parental persistently infected cells (Dami-P), as well as on derived clones (Dami-Cl). We report that in these nonlytic and no...

journal_title：AIDS research and human retroviruses

authors： Wybier-Franqui J,Tobaly-Tapiero J,Coronel A,Giron ML,Chopin-Robert C,Peries J,Emanoil-Ravier R

更新日期：1995-07-01 00:00:00

abstract：:The incidence of anal cancer is increased in HIV-infected patients compared with the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late-stage HIV disease. We performed a ...

journal_title：AIDS research and human retroviruses

authors： Frank M,Lahiri CD,Nguyen ML,Mehta CC,Mosunjac M,Flowers L

更新日期：2018-07-01 00:00:00

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:In this report we have highlighted only a few examples of the extensive efforts underway to better understand the process of HIV pathogenesis, to develop new therapeutic agents to inhibit virus replication, and to identify strategies to restore damage done to the immune system during HIV disease progression. It is exp...

journal_title：AIDS research and human retroviruses

authors： Miller RH,Turk SR,Black RJ,Bridges S,Sarver N

更新日期：1996-07-01 00:00:00

abstract：:HIV antigens were detected by immunoelectron microscopy at the surface of human and simian T4 lymphocytes that had been infected in vitro. HIV antigens were detected at the surface of cells exhibiting viral particles but also at the surface of cells before the release of virions. The latter cells may be considered imm...

journal_title：AIDS research and human retroviruses

authors： Desportes I,Bonnet D,Nicol I,Snart R,Sarin P

更新日期：1989-02-01 00:00:00

abstract：:HIV infection is associated with a state of chronic, generalized immune activation that has been shown in many studies to be a key predictor of progression to AIDS. Consistent with this model, nonpathogenic SIV infections of natural hosts, such as the sooty mangabeys, are characterized by low levels of immune activati...

journal_title：AIDS research and human retroviruses

authors： d'Ettorre G,Paiardini M,Ceccarelli G,Silvestri G,Vullo V

更新日期：2011-04-01 00:00:00

abstract：:Understanding factors that affect heterosexual transmission of HIV in women is of great importance. Lactobacilli in the lower genital tract of women utilize glycogen in vaginal epithelial cells as an energy source and produce lactic acid. The resultant vaginal acidity is believed to provide protection against HIV infe...

journal_title：AIDS research and human retroviruses

authors： Mirmonsef P,Gilbert D,Veazey RS,Wang J,Kendrick SR,Spear GT

更新日期：2012-01-01 00:00:00

abstract：:The domain of HIV-2 Vpx previously shown to be important for virion incorporation has been mapped to residues 73--89. Mutational analysis of this domain was employed to further define the sequences important for incorporation into virus-like particles, using a vaccinia virus expression system. Deletion of residues 73-...

journal_title：AIDS research and human retroviruses

authors： Jin L,Zhou Y,Ratner L

更新日期：2001-01-20 00:00:00

abstract：:Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

journal_title：AIDS research and human retroviruses

authors： Cox S,Margot N,Miller M,Callebaut C

更新日期：2018-05-01 00:00:00

abstract：:Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. We explore the merits of using signature patterns for analysis of HIV-1 (human immunodeficiency virus type 1...

journal_title：AIDS research and human retroviruses

authors： Korber B,Myers G

更新日期：1992-09-01 00:00:00

abstract：:HIV-1 transcripts are generated through a complex alternative splicing mechanism, resulting in the production of multiple RNAs coding for each viral protein. HIV-1 RNA splicing has been analyzed mostly in in vitro assays, and in vivo data are scarce. Here we analyze HIV-1 transcripts generated in peripheral blood mono...

journal_title：AIDS research and human retroviruses

authors： Carrera C,Pinilla M,Pérez-Alvarez L,Thomson MM

更新日期：2010-07-01 00:00:00

abstract：:We generated DNA constructs expressing soluble truncated forms of the envelope of SF162, a neutralization-resistant primary human immunodeficiency virus type 1 isolate, and SF162AV2, a neutralization-susceptible virus derived from SF162 after the deletion of 30 amino acids from the V2 loop. The constructs express the ...

journal_title：AIDS research and human retroviruses

authors： Stamatatos L,Lim M,Cheng-Mayer C

更新日期：2000-07-01 00:00:00

abstract：:We set out to investigate whether there are clinically significant consequences when children with perinatal exposure to single-dose nevirapine are initiated on a nonnucleoside reverse transcriptase inhibitor (NNRTI) containing a highly active antiretroviral therapy (HAART) regimen. We carried out a chart and database...

journal_title：AIDS research and human retroviruses

authors： Musiime V,Ssali F,Kayiwa J,Namala W,Kizito H,Kityo C,Mugyenyi P

更新日期：2009-10-01 00:00:00

abstract：:The surface envelope glycoprotein gp46 of the human T cell leukemia virus type 1 elicits a strong immune response. Its protective role against HTLV-1 infection in animal models is well established, suggesting that recombinant envelope glycoproteins or synthetic peptides could be used as an effective vaccine. However, ...

journal_title：AIDS research and human retroviruses

authors： Tallet B,Astier-Gin T,Moynet D,Londos-Gagliardi D,Guillemain B

更新日期：2001-03-01 00:00:00

abstract：:The measurement of antiretroviral concentrations in hair is emerging as an important technology to objectively quantify adherence to combination antiretroviral therapy. Hair levels of antiretrovirals are the strongest independent predictor of virologic success in large prospective cohorts of HIV-infected patients and ...

journal_title：AIDS research and human retroviruses

authors： Gandhi M,Yang Q,Bacchetti P,Huang Y

更新日期：2014-01-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:Genotropism was determined in 608 Brazilian samples collected in dried blood spots using Polyethersulfone collection cards. Patients were infected by subtype B (88.8%), F (5.6%), C (3.3%), A (1.8%), and G (0.5%). All patients were exposed to three classes of antiretrovirals, and 59.8% of the samples harbored R5 viruse...

journal_title：AIDS research and human retroviruses

authors： Lavigne S,Santos C,Arif MS,Reis A,Samer S,Dos Santos CV,Diaz RS

更新日期：2014-02-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus mo...

journal_title：AIDS research and human retroviruses

authors： Reimann KA,Burkly LC,Burrus B,Waite BC,Lord CI,Letvin NL

更新日期：1993-03-01 00:00:00

abstract：:A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium d...

journal_title：AIDS research and human retroviruses

authors： Cotter EJ,Malizia AP,Chew N,Powderly WG,Doran PP

更新日期：2007-12-01 00:00:00

abstract：:The presence of transmitted drug-resistant HIV-1 (TDR) at the time of antiretroviral therapy (ART) initiation is associated with failure to achieve viral load suppression. Rates of TDR in ART-naive patients have been reported from various parts of the world through ongoing national, regional, and global evaluations; h...

journal_title：AIDS research and human retroviruses

authors： MacVeigh MS,Kosmetatos MK,McDonald JE,Reeder JL,Parrish DA,Young TP

更新日期：2013-02-01 00:00:00