Evaluation of -2 RANTES vaginal microbicide formulations in a nonhuman primate simian/human immunodeficiency virus (SHIV) challenge model.

abstract：:Susceptibility to HIV infection was examined in macrophages differentiated from human monocytes by macrophage colony-stimulating factor (M-CSF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). The replication of macrophage-tropic human immunodeficiency virus type-1 (HIV-1), which was determined by reverse...

journal_title：AIDS research and human retroviruses

authors： Matsuda S,Akagawa K,Honda M,Yokota Y,Takebe Y,Takemori T

更新日期：1995-09-01 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

更新日期：2011-05-01 00:00:00

abstract：:The efficacy and safety of recombinant human interferon gamma (rIFN-gamma) in the reduction of opportunistic disease in patients with advanced HIV-1 infection are assessed. A 12-month double-blind, placebo-controlled, multicenter, Phase III trial of rIFN-gamma in HIV-positive patients with CD4 < 100 x 10(9)/liter on s...

journal_title：AIDS research and human retroviruses

authors： Riddell LA,Pinching AJ,Hill S,Ng TT,Arbe E,Lapham GP,Ash S,Hillman R,Tchamouroff S,Denning DW,Parkin JM

更新日期：2001-06-10 00:00:00

abstract：:All-trans-retinoic acid (RA) has been shown either to activate or repress human immunodeficiency virus type 1 (HIV-1) replication in primary monocyte-derived-macrophages (MDMs). We systematically investigated the contribution that cell donor and virus differences make to this variability. We found that the effect of R...

journal_title：AIDS research and human retroviruses

authors： Brown XQ,Hanley TM,Viglianti GA

更新日期：2002-06-10 00:00:00

abstract：:HGP-30-KLH vaccine in alum at doses of 10, 25, 50, and 100 micrograms/kg administered intramuscularly at weeks 0, 4, and 10 appear well-tolerated clinically. Local pain at the injection site, appears to be the main clinical toxicity. Laboratory parameters are not affected by administration of the vaccine candidate exc...

journal_title：AIDS research and human retroviruses

authors： Kahn JO,Stites DP,Scillian J,Murcar N,Stryker R,Volberding PA,Naylor PH,Goldstein AL,Sarin PS,Simmon VF

更新日期：1992-08-01 00:00:00

abstract：:HIV-1 infection evokes a vigorous antiviral response that may participate in resolving the initial peak of plasma viremia and maintenance of the asymptomatic state. CD8+ T lymphocytes of HIV-1-infected individuals play a critical role in the cellular anti-HIV response. In agreement with previous reports, we observed a...

journal_title：AIDS research and human retroviruses

authors： Chen CH,Weinhold KJ,Bartlett JA,Bolognesi DP,Greenberg ML

更新日期：1993-11-01 00:00:00

abstract：:Serological studies on 926 blood samples from 703 Brazilian Kayapo (Cayapo) Indians showed, by conventional definition of HTLV seropositivity, a 28% prevalence of human T lymphotropic virus (HTLV) infection, the highest yet reported. Immunoblot (WB) and SYNTH-EIA patterns indicate that the predominant infecting agent ...

journal_title：AIDS research and human retroviruses

authors： Black FL,Biggar RJ,Neel JV,Maloney EM,Waters DJ

更新日期：1994-09-01 00:00:00

abstract：:Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. We explore the merits of using signature patterns for analysis of HIV-1 (human immunodeficiency virus type 1...

journal_title：AIDS research and human retroviruses

authors： Korber B,Myers G

更新日期：1992-09-01 00:00:00

abstract：:The aim of this study was to compare the extent of resistance to antiretroviral (ARV) drugs among the population in Mexico before and after 2005. The mutations and drug resistance database of Stanford University were used for analyzing drug resistance tests that had been performed on HIV treatment-naive patients. The ...

journal_title：AIDS research and human retroviruses

authors： Escoto-Delgadillo M,Torres-Mendoza BM,Flores-Soto M,Vazquez-Valls E

更新日期：2016-12-01 00:00:00

abstract：:We report the results of an external quality control program, including 17 Italian centers involved in the care of patients infected by HIV, to evaluate CD4 T cell count proficiency and reproducibility. The centers received two commercial stabilized blood preparations, one with "normal" and one with "low" CD4 T cell c...

journal_title：AIDS research and human retroviruses

authors： Martini F,D'Offizi G,Girardi E,Vitale A,Cimini E,Mollicone B,Vlassi C,Aiuti F,Other Members of 2005 Italian CD4 Quality Control Network.

更新日期：2007-06-01 00:00:00

abstract：:CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

journal_title：AIDS research and human retroviruses

authors： Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

更新日期：2016-10-01 00:00:00

abstract：:HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. T...

journal_title：AIDS research and human retroviruses

authors： He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

更新日期：2011-10-01 00:00:00

abstract：:To establish whether the low cysteine and glutathione levels in HIV-infected patients and SIV-infected rhesus macaques may be consequences of an abnormal cysteine catabolism, we analyzed sulfate and glutathione levels in macaques. Muscle tissue (m. vastus lateralis and m. gastrocnemius) of SIV-infected macaques (n = 2...

journal_title：AIDS research and human retroviruses

authors： Gross A,Hack V,Stahl-Hennig C,Dröge W

更新日期：1996-11-20 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:A novel deletion of residue 69 of the HIV-1 reverse transcriptase (RT) gene was detected in combination with mutations V75I/V and F77L/F in a patient with partial virological response to several antiretroviral drug regimens, including stavudine (D4T), didanosine (DDI), lamivudine (3TC), saquinavir (SQV), and nevirapin...

journal_title：AIDS research and human retroviruses

authors： Suzuki K,Kaufmann GR,Mukaide M,Cunningham P,Harris C,Leas L,Kondo M,Imai M,Pett SL,Finlayson R,Zaunders J,Kelleher A,Cooper DA

更新日期：2001-09-01 00:00:00

abstract：:The structure of the Vpu protein of human immunodeficiency virus type 1 (HIV-1) is composed of a short Nterminal domain (NTD), a transmembrane domain (TM), and a cytoplasmic domain (CD). Previous studies have shown that the Vpu protein from subtype B HIV-1 is transported predominantly to the rough endoplasmic reticulu...

journal_title：AIDS research and human retroviruses

authors： Pacyniak E,Gomez ML,Gomez LM,Mulcahy ER,Jackson M,Hout DR,Wisdom BJ,Stephens EB

更新日期：2005-05-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) is a leading cause of mortality and morbidity in the world, with almost 46 million people infected globally. HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countries have non-subtype...

journal_title：AIDS research and human retroviruses

authors： Munkanta M,Handema R,Kasai H,Gondwe C,Deng X,Yamashita A,Asagi T,Yamamoto N,Ito M,Kasolo F,Terunuma H

更新日期：2005-10-01 00:00:00

abstract：:Maraviroc is a first-in-class chemokine coreceptor type-5 (CCR5) antagonist with demonstrated immunovirologic activity in treatment-experienced (TE) patients with CCR5 (R5)-tropic HIV-1; however, experience in regimens containing newer antiretroviral agents is limited. The primary objective of this 96-week open-label,...

journal_title：AIDS research and human retroviruses

authors： Furtado J,Madruga JV,Bicudo EL,da Eira M,Lopes MI,Netto EM,Santini-Oliveira M,Leite OH,Machado AA,Tupinambas U,de Andrade Neto JL,Lima MP,Pedro Rde J,Miranda AF,Lewi DS,Santos BR,Portsmouth S,Wajsbrot DB,Cassoli LM

更新日期：2013-09-01 00:00:00

abstract：:A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental subunit HIV-1 vaccine containing a truncated recombinant HIV-1 envelope protein (gp160D) adsorbed to alum. Antibody responses were meas...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Wu JY,Coughlin RT,Murphy CI,Seals JR,Wyand MS,Kensil CR

更新日期：1992-08-01 00:00:00

abstract：:We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed se...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Gagarina EY,Lukyanova NS,Danilova TV

更新日期：2006-11-01 00:00:00

abstract：:The World Health Organizations HIV Drug Resistance (WHO HIVDR) Threshold survey method was used to assess transmitted HIVDR in newly diagnosed HIV-1-infected primigravida women attending the Prevention of Parent to Child Transmission (PPTCT) centers in Kakinada, in whom it is likely that the infection had recently occ...

journal_title：AIDS research and human retroviruses

authors： Thorat SR,Chaturbhuj DN,Hingankar NK,Chandrasekhar V,Koppada R,Datkar SR,Srikantiah P,Garg R,Kabra S,Haldar P,Reddy DC,Bachani D,Tripathy SP,Paranjape RS

更新日期：2011-12-01 00:00:00

abstract：:We sought to determine the frequency and profile of HIV-1 BF recombinants in vitro and in vivo. Laboratory HIV-1 strains from subtypes B and F were cocultured and evaluated. Clinical samples from the city of Santos, Brazil, where the first HIV-1 B/F circulating recombinant forms (CRF) were described, were also assesse...

journal_title：AIDS research and human retroviruses

authors： Teixeira D,Munerato P,Komninakis SC,Fusuma EE,Janini LM,Sucupira MC,Diaz RS

更新日期：2010-09-01 00:00:00

abstract：:A higher functionality of CD8(+) T cells might contribute to low-level HIV replication in long-term nonprogressors (LTNPs). However, the contrary could also be true, being the function of CD8(+) T cells modulated by HIV replication. We tested whether enhanced HIV replication following antiretroviral therapy interrupti...

journal_title：AIDS research and human retroviruses

authors： López M,Rallón N,Soriano V,Rodríguez I,Valencia E,Labarga P,Moreno V,Vispo E,Roncal F,González-Lahoz J,Benito JM

更新日期：2008-09-01 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6), a lymphotropic herpesvirus, has been suggested as a potential cofactor in the acquired immunodeficiency syndrome (AIDS). Previous studies indicate that HHV-6 has a restricted range of susceptible species. In this study, we tested the in vitro susceptibility to HHV-6 of Macaca nemestrina (p...

journal_title：AIDS research and human retroviruses

authors： Lusso P,Secchiero P,Crowley RW

更新日期：1994-02-01 00:00:00

abstract：:A previously described self-complementary oligodeoxynucleotide termed triplex-forming oligodeoxynucleotide (TFO A), 54 bases in length, designed against the polypurine tract of HIV-1 RNA, inhibited viral replication at a 1 to 3 microM concentration in acutely infected cells, whereas antisense and scrambled sequence ol...

journal_title：AIDS research and human retroviruses

authors： Jendis J,Strack B,Volkmann S,Böni J,Mölling K

更新日期：1996-08-10 00:00:00

abstract：:We evaluated the performance of T-SPOT.TB (a commercial interferon gamma release assay) and its accuracy for the diagnosis of active tuberculosis (TB) among HIV-infected subjects with advanced immunodeficiency. In a clinical prospective study, we assessed the performance of T-SPOT.TB for the diagnosis of active TB in ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Sun J,Zhang R,Liu L,Zheng Y,Shen Y,Wang Z,Sun F,Li L,Lu H

更新日期：2011-03-01 00:00:00

abstract：:The domain of HIV-2 Vpx previously shown to be important for virion incorporation has been mapped to residues 73--89. Mutational analysis of this domain was employed to further define the sequences important for incorporation into virus-like particles, using a vaccinia virus expression system. Deletion of residues 73-...

journal_title：AIDS research and human retroviruses

authors： Jin L,Zhou Y,Ratner L

更新日期：2001-01-20 00:00:00