Short communication: adhesion pathways utilized by HIV-infected lymphocytes.

Abstract:

:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. We further demonstrate that HIV-infected lymphocytes require Rap-1 activity for phorbol-stimulated adhesion. Understanding adhesion pathways used by HIV-infected lymphocytes may lead to interventions to regulate aberrant adhesion and migration.

authors

Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

doi

10.1089/AID.2011.0262

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1557-60

issue

12

eissn

0889-2229

issn

1931-8405

journal_volume

28

pub_type

杂志文章
  • Tax gene characterization of human T-lymphotropic virus type 1 strains from Brazilian HIV-coinfected patients.

    abstract::The tax gene of human T-lymphotropic virus type 1 (HTLV-1) diverges among isolates according to geographic regions and has been classified into two genotypes: taxA and taxB. In Brazil, taxA is the most prevalent genotype in symptomatic and asymptomatic carriers. Few studies have been conducted in HIV-infected patients...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2011.0389

    authors: Magri MC,Brigido LF,Rodrigues R,Morimoto HK,Caterino-de-Araujo A

    更新日期:2012-12-01 00:00:00

  • HIV Drug Resistance in Antiretroviral-Naive Patients in Mexico After 10 Years: Is There a Difference?

    abstract::The aim of this study was to compare the extent of resistance to antiretroviral (ARV) drugs among the population in Mexico before and after 2005. The mutations and drug resistance database of Stanford University were used for analyzing drug resistance tests that had been performed on HIV treatment-naive patients. The ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2016.0143

    authors: Escoto-Delgadillo M,Torres-Mendoza BM,Flores-Soto M,Vazquez-Valls E

    更新日期:2016-12-01 00:00:00

  • Identification of mutations in proviral long terminal repeats of HIV type 1-infected subjects naive to drug therapy.

    abstract::Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp dele...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2004.20.1019

    authors: Copeland KF,Chen Z,Fiebig M,Ni L,Savoy S,Smaill FM,Rosenthal KL,Kim JE

    更新日期:2004-09-01 00:00:00

  • Lymphocyte homeostasis in HIV-infected northern Thais.

    abstract::Cross-sectional laboratory data were used to model the patterns of total lymphocyte count and lymphocyte subpopulation counts among persons with chronic HIV-1 subtype E (CRF01_AE) infection during the 6.5 years preceding death. The data cover 331 HIV-infected decedents from a heterosexual HIV transmission study of 590...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/0889222041217491

    authors: Kingkeow D,Heilig CM,Costello C,Sennun S,Suriyanon V,Rungruengthanakit K,Taejaroenkul S,Nelson KE,Duerr A

    更新日期:2004-06-01 00:00:00

  • Analysis of human immunodeficiency virus type 1 containing HERV-K protease.

    abstract::The human endogenous retrovirus, type K (HERV-K) represents the most biologically active form of known retroelements present in the human genome. Several HERV-K genomes have transcriptionally active open reading frames and encode their own protease (PR). The HERV-K PR has been shown to authentically cleave human immun...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/088922200750054701

    authors: Padow M,Lai L,Fisher RJ,Zhou YC,Wu X,Kappes JC,Towler EM

    更新日期:2000-12-10 00:00:00

  • Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.

    abstract::Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1997.13.945

    authors: Staats HF,Montgomery SP,Palker TJ

    更新日期:1997-07-20 00:00:00

  • Treatment outcomes of HIV-infected adolescents attending public-sector HIV clinics across Gauteng and Mpumalanga, South Africa.

    abstract::There is little evidence comparing treatment outcomes between adolescents and other age groups, particularly in resource-limited settings. A retrospective analysis of data from seven HIV clinics across urban Gauteng (n=5) and rural Mpumalanga (n=2), South Africa was conducted. The analysis compared HIV-positive antire...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2012.0215

    authors: Evans D,Menezes C,Mahomed K,Macdonald P,Untiedt S,Levin L,Jaffray I,Bhana N,Firnhaber C,Maskew M

    更新日期:2013-06-01 00:00:00

  • Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs.

    abstract::The extraordinarily high mutation rate of HIV suggests that the viral population exists near the threshold for viral viability. An increase in mutation could mediate a lethal increase in the already high proportion of defective viruses. We initially tested this hypothesis by culturing HIV-infected cells in mutagenic d...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/088922200309539

    authors: Loeb LA,Mullins JI

    更新日期:2000-01-01 00:00:00

  • Longitudinal Trends in Western Australian HIV-1 Sequence Diversity and Viral Transmission Networks and Their Influence on Clinical Parameters: 2000-2014.

    abstract::We examined baseline HIV-1 protease and reverse transcriptase sequences and HIV clinical parameters from 1,021 consecutive patients (814 male, 207 female) through the Royal Perth Hospital HIV service to investigate HIV-1 subtype diversity and local phylogenetic networks from 2000 to 2014. HIV-1 subtype B virus sequenc...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2015.0206

    authors: Castley AS,Gaudieri S,James I,Gizzarelli LS,Guelfi G,John M,Nolan D

    更新日期:2016-03-01 00:00:00

  • Nelfinavir in HIV-HCV coinfected patients: a 24-month follow-up in a cohort of 82 patients.

    abstract::This retrospective and longitudinal study evaluated the long-term hepatic tolerance of a nelfinavir (NFV)-antiretroviral combined regimen in 82 patients of the HCV-HIV Cohort of CISIH-Sud of Marseilles. Follow-up data (liver enzyme levels, CD4 cell count, HIV viral load, and metabolic parameters) of patients treated w...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2005.21.841

    authors: Poizot-Martin I,Marimoutou C,Drogoul-Vey MP,Vion-Dury F,Frixon-Marin V,Benhaim S,Poggi P,Gastaut JA

    更新日期:2005-10-01 00:00:00

  • HIV-1 subtype C reverse transcriptase sequences from drug-naive pregnant women in South Africa.

    abstract::The HIV-1 reverse transcriptase genes from 37 HIV-1-positive pregnant women attending an antenatal clinical in Soweto, South Africa were sequenced and analyzed for the presence of drug resistance mutations. All women were antiretroviral drug naive, but were being screened as potential participants in clinical trials o...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/088922202753747950

    authors: Pillay C,Bredell H,McIntyre J,Gray G,Morris L

    更新日期:2002-05-20 00:00:00

  • Investigation of proviral load in individuals infected with human T-lymphotropic virus type II.

    abstract::Human T-lymphotrophic virus type II (HTLV-II) has not yet been associated with any disease. Little is known about the proviral loads of HTLV-II in vivo and its relationship, if any, to lack of pathogenicity. We determined the HTLV-II proviral copy number in peripheral blood lymphocyte (PBL) samples from 49 HTLV-II-inf...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1995.11.1235

    authors: Woods TC,Graber JM,Hershow RC,Khabbaz RF,Kaplan JE,Heneine W

    更新日期:1995-10-01 00:00:00

  • Elevated hepatic gamma-glutamylcysteine synthetase activity and abnormal sulfate levels in liver and muscle tissue may explain abnormal cysteine and glutathione levels in SIV-infected rhesus macaques.

    abstract::To establish whether the low cysteine and glutathione levels in HIV-infected patients and SIV-infected rhesus macaques may be consequences of an abnormal cysteine catabolism, we analyzed sulfate and glutathione levels in macaques. Muscle tissue (m. vastus lateralis and m. gastrocnemius) of SIV-infected macaques (n = 2...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1996.12.1639

    authors: Gross A,Hack V,Stahl-Hennig C,Dröge W

    更新日期:1996-11-20 00:00:00

  • Correlation of Antibody Responses to a Peptide Antigen gp120-C5501-512/gp41732-744 with HIV Disease Progression.

    abstract::Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease progression. This is one of the regions on gp120 that interact with the transmembrane glycoprotein, gp41, anchoring it to the viral and infected cell membrane. This study...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2016.0184

    authors: Sørensen B,Sommerfelt MA,Stjernholm G,Smith PL,Ökvist M,Hovden AO,Hoddevik G,Redfield R,Ustina V,Jelmert Ø,Zeldis J,Dalgleish A

    更新日期:2017-06-01 00:00:00

  • Simian immunodeficiency virus (mac 251-32H) transmembrane protein sequence remains conserved throughout the course of infection in macaques.

    abstract::Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). The polymerase chain reaction (PCR) was used to amplify the env gp41, rev, and nef overlapping coding sequences from provirus present in the blood of both animals at 1, 6, and 15 months po...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1993.9.133

    authors: Slade A,Jones S,Almond N,Kitchin P

    更新日期:1993-02-01 00:00:00

  • Molecular cloning and characterization of a German HIV-1 isolate.

    abstract::The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1990.6.813

    authors: Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

    更新日期:1990-06-01 00:00:00

  • Low rate of transmitted drug resistance may indicate low access to antiretroviral treatment in Maranhão State, northeast Brazil.

    abstract::The Brazilian AIDS epidemic is characterized by significant geographic contrasts: a reduction in incidence and mortality in the epicenter (southeast) and an increase in the northeast. HIV-1-transmitted drug resistance (TDR) and genetic diversity were investigated among 106 antiretroviral (ARV)-naive patients from Mara...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2014.0261

    authors: Moura ME,Reis MN,Lima YA,Eulálio KD,Cardoso LP,Stefani MM

    更新日期:2015-02-01 00:00:00

  • Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques.

    abstract::Preexposure prophylaxis (PrEP) with antiretroviral drugs constitutes a promising strategy for HIV prevention. Potent PrEP regimens with reverse transcriptase inhibitors can prevent detectable SHIV infection in a repeated low-dose macaque model that resembles human transmission, supporting plans to quickly move this ap...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2007.0222

    authors: Kersh EN,Luo W,Adams DR,Mitchell J,Garcia-Lerma JG,Heneine W,Folks TM,Butera S,Otten RA

    更新日期:2008-04-01 00:00:00

  • Genotypic analysis of human immunodeficiency virus type 1 env V3 loop sequences: bioinformatics prediction of coreceptor usage among 28 infected mother-infant pairs in a drug-naive population.

    abstract::We sought to predict virus coreceptor utilization using a simple bioinformatics method based on genotypic analysis of human immunodeficiency virus types 1 (HIV-1) env V3 loop sequences of 28 infected but drug-naive women during pregnancy and their infected infants and to better understand coreceptor usage in vertical ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2010.0142

    authors: Duri K,Soko W,Gumbo F,Kristiansen K,Mapingure M,Stray-Pedersen B,Muller F,BHAMC Group.

    更新日期:2011-04-01 00:00:00

  • A longitudinal study of the changes in body fat and metabolic parameters in a South African population of HIV-positive patients receiving an antiretroviral therapeutic regimen containing stavudine.

    abstract::The aim of this study was to determine the patterns of change in body fat and metabolic parameters in a South African cohort on a first line ART regimen containing stavudine. Fasting lipogram, blood glucose and insulin levels, CD4 cell count, viral load, BMI, waist-to-hip ratio (WHR), and skinfold thickness at the tri...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2008.0308

    authors: George JA,Venter WD,Van Deventer HE,Crowther NJ

    更新日期:2009-08-01 00:00:00

  • Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.

    abstract::To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial dep...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1998.14.1187

    authors: Stebbings R,Stott J,Almond N,Hull R,Lines J,Silvera P,Sangster R,Corcoran T,Rose J,Cobbold S,Gotch F,McMichael A,Walker B

    更新日期:1998-09-01 00:00:00

  • Conserved immunogenic region of a major core protein (p24) of human and simian immunodeficiency viruses.

    abstract::A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1988.4.409

    authors: Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

    更新日期:1988-12-01 00:00:00

  • Surveillance of transmitted HIV type 1 drug resistance among HIV type 1-positive women attending an antenatal clinic in Kakinada, India.

    abstract::The World Health Organizations HIV Drug Resistance (WHO HIVDR) Threshold survey method was used to assess transmitted HIVDR in newly diagnosed HIV-1-infected primigravida women attending the Prevention of Parent to Child Transmission (PPTCT) centers in Kakinada, in whom it is likely that the infection had recently occ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2011.0036

    authors: Thorat SR,Chaturbhuj DN,Hingankar NK,Chandrasekhar V,Koppada R,Datkar SR,Srikantiah P,Garg R,Kabra S,Haldar P,Reddy DC,Bachani D,Tripathy SP,Paranjape RS

    更新日期:2011-12-01 00:00:00

  • Near full-length sequence analysis of a Unique CRF01_AE/B recombinant from Kuala Lumpur, Malaysia.

    abstract::A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2007.0056

    authors: Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

    更新日期:2007-09-01 00:00:00

  • Prediction of virological response to lopinavir/ritonavir using the genotypic inhibitory quotient.

    abstract::The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/088922204322996509

    authors: González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

    更新日期:2004-03-01 00:00:00

  • Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile.

    abstract::The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0192

    authors: Cerejo P,Santos-Costa Q,Calado M,Espírito-Santo M,Parreira R,Azevedo-Pereira JM

    更新日期:2018-02-01 00:00:00

  • Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients.

    abstract::The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following en...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2006.0248

    authors: Passam AM,Sourvinos G,Krambovitis E,Miyakis S,Stavrianeas N,Zagoreos I,Spandidos DA

    更新日期:2007-08-01 00:00:00

  • Amplification of simian retroviral sequences from human recipients of baboon liver transplants.

    abstract::Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1998.14.821

    authors: Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

    更新日期:1998-07-01 00:00:00

  • Prevalence of drug-resistant HIV type 1 at the time of initiation of antiretroviral therapy in Portland, Oregon.

    abstract::The presence of transmitted drug-resistant HIV-1 (TDR) at the time of antiretroviral therapy (ART) initiation is associated with failure to achieve viral load suppression. Rates of TDR in ART-naive patients have been reported from various parts of the world through ongoing national, regional, and global evaluations; h...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2011.0386

    authors: MacVeigh MS,Kosmetatos MK,McDonald JE,Reeder JL,Parrish DA,Young TP

    更新日期:2013-02-01 00:00:00

  • Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity.

    abstract::We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1991.7.975

    authors: Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

    更新日期:1991-12-01 00:00:00