Abstract:
:To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial depletion of CD8+ cells by antibody treatment was achieved. On the day of challenge peripheral CD2+CD4-CD8+ cell counts were reduced by 92 and 95%, respectively, in animals N109 and N112 and their lymph nodes revealed a 46 and 58% reduction, respectively, in CD2+CD4-CD8+ cells. Two other pC8-immunized macaques, N110 and N111, treated in the same way, did not show significant depletion of CD8+ cells. None of these four pC8-immunized animals became infected when challenged with 50 MID50 of pJ5. Treatment of a further four pC8-infected and protected macaques and two naive control animals with Campath-1H antibody successfully depleted peripheral CD3+ cell counts by >99% in all treated animals. Campath-1H depletion resulted in enhanced, longer lasting lymphoid depletion. Yet subsequent challenge with 20 MID50 of pJ5 still failed to infect the pC8-immunized animals. All eight of the naive controls, including two Campath-1H-treated animals, became infected following challenge. In summary, partial depletion of circulating CD8+ cells or total lymphocytes prior to challenge failed to abrogate the protection conferred by vaccination with pC8.
journal_name
AIDS Res Hum Retrovirusesjournal_title
AIDS research and human retrovirusesauthors
Stebbings R,Stott J,Almond N,Hull R,Lines J,Silvera P,Sangster R,Corcoran T,Rose J,Cobbold S,Gotch F,McMichael A,Walker Bdoi
10.1089/aid.1998.14.1187subject
Has Abstractpub_date
1998-09-01 00:00:00pages
1187-98issue
13eissn
0889-2229issn
1931-8405journal_volume
14pub_type
杂志文章abstract::This prospective, open-label, multicenter trial evaluated the effects of once-weekly (qw) epoetin alfa on quality of life (QOL) and hemoglobin (Hb) levels in anemic human immunodeficiency virus (HIV)-infected adult receiving antiretroviral therapy. A total of 650 patients with Hb < or = 11 g/dl received epoetin alfa 4...
journal_title:AIDS research and human retroviruses
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:AIDS research and human retroviruses
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
doi:10.1089/aid.1989.5.279
更新日期:1989-06-01 00:00:00
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章,随机对照试验
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 临床试验,杂志文章
doi:10.1089/aid.1996.12.547
更新日期:1996-04-10 00:00:00
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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abstract::To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...
journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
doi:10.1089/aid.1998.14.561
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